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Meiyue Song1,Jiaxin Wang2,Youliang Sun3,Junling Pang1,Xiaona Li1,Yuan Liu4,5,6,Yitian Zhou6,7,Peiran Yang1,Tianhui Fan1,Ying Liu1,Zhaoguo Li8,Xianmei Qi1,Baicun Li1,Xinri Zhang9,Jing Wang1,Chen Wang1,4,5(State Key Laboratory of Medical Molecular Biology,Department of Physiology,Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking Union Medical College;Tsinghua-Peking Center for Life Sciences,Department of Biology,College of Medicine,Tsinghua University;School of Pharmaceutical Sciences,Tsinghua University;Department of Pulmonary and Critical Care Medicine,Center of Respiratory Medicine,China-Japan Friendship Hospital;National Clinical Research Center for Respiratory Diseases;Peking Union Medical College,Chinese Academy of Medical Sciences;Peking Union Medical College,MD Program;Department of Respiratory,the Second Affiliated Hospital of Harbin Medical University;Department of Pulmonary and Critical Care Medicine,the First Hospital of Shanxi Medical University).Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis[J].Acta Pharmaceutica Sinica B,2022,第3期
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Cancan Zheng1,Xiaomei Yu1,Yiyao Liang2,Yidong Zhu3,Yan He3,Long Liao1,Dingkang Wang1,Yanming Yang1,Xingfeng Yin1,Ang Li2,Qingyu He1,Bin Li1(MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes,Institute of Life and Health Engineering,Jinan University;Guangdong Key Laboratory of Non-human Primate Research,Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Key Laboratory of CNS Regeneration,Ministry of Education,Jinan University;MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine,National Engineering Research Center of Genetic Medicine,Institute of Biomedicine,College of Life Science and Technology,Jinan University).Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner[J].Acta Pharmaceutica Sinica B,2022,第3期
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Xu Zhang1,2,Yuxiang Wang1,Linghua Meng1,2(Division of Anti-tumor Pharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;University of Chinese Academy of Sciences).Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma:New opportunities towards molecularly targeted therapy[J].Acta Pharmaceutica Sinica B,2022,第3期
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Geni Ye1,2,Maohua Huang1,2,3,Yong Li1,2,Jie Ouyang1,2,Minfeng Chen1,2,Qing Wen1,2,Xiaobo Li1,2,Huhu Zeng1,2,Pei Long1,2,Zepei Fan4,Junqiang Yin4,Wencai Ye1,2,Dongmei Zhang1,2(College of Pharmacy,Jinan University;Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research,Jinan University;Integrated Chinese and Western Medicine Postdoctoral Research Station,Jinan University;Department of Musculoskeletal Oncology,the First Affiliated Hospital of Sun Yat-sen University).The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway[J].Acta Pharmaceutica Sinica B,2022,第3期
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Jiwei Cui1,2,Yuanxin Xu1,2,Haiyan Tu1,2,Huacong Zhao1,2,Honglan Wang1,2,Liuqing Di1,2,Ruoning Wang1,2(College of Pharmacy,Nanjing University of Chinese Medicine;Jiangsu Provincial TCM Engineering Technology,Research Center of High Efficient Drug Delivery System).Gather wisdom to overcome barriers:Well-designed nano-drug delivery systems for treating gliomas[J].Acta Pharmaceutica Sinica B,2022,第3期
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Fangfang Wang1,2,Sora Jin3,Franklin Mayca Pozo3,Danmei Tian1,2,Xiyang Tang1,2,Yi Dai1,2,Xinsheng Yao1,2,Jinshan Tang1,2,Youwei Zhang3(Institute of Traditional Chinese Medicine and Natural Products,College of Pharmacy,Jinan University;Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drug Research,Jinan University;Department of Pharmacology,Case Comprehensive Cancer Center,Case Western Reserve University School of Medicine).Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR[J].Acta Pharmaceutica Sinica B,2022,第3期
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Yumei Wang1,Jia Ke1,Xianmou Guo1,Kaijun Gou1,Zhentao Sang2,Yanbu Wang1,2,Yan Bian2,Sanming Li1,Heran Li2(Department of Pharmaceutics,Shenyang Pharmaceutical University;School of Pharmacy,China Medical University).Chiral mesoporous silica nano-screws as an efficient biomimetic oral drug delivery platform through multiple topological mechanisms[J].Acta Pharmaceutica Sinica B,2022,第3期
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Wei Zhang1,,3;Chengchao Xu1,,4;Jichao Sun1;Han-Ming Shen5;Jigang Wang1,,4,6;Chuanbin Yang1(Department of Geriatrics, Shenzhen People’s Hospital (the Second Clinical Medical College, Jinan University;the First Affiliated Hospital, Southern University of Science and Technology);Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University;Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences;Faculty of Health Sciences, University of Macau;Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University).Impairment of the autophagy-lysosomal pathway in Alzheimer’s diseases:Pathogenic mechanisms and therapeutic potential[J].Acta Pharmaceutica Sinica B,2022,第3期
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Guoping Shu1,Yueli Tang1,Mingyuan Yuan1,Ning Wei1,Fangyuan Zhang1,Chunxian Yang1,Xiaozhong Lan2,Min Chen3,Kexuan Tang1,Lien Xiang4,Zhihua Liao1(Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education),Chongqing Engineering Research Centre for Sweet Potato,SWU-TAAHC Medicinal Plant Joint R&D Centre,School of Life Sciences,Southwest University;TAAHC-SWU Medicinal Plant Joint R&D Centre,Xizang Agricultural and Husbandry College;College of Pharmaceutical Sciences,Southwest University;College of Environmental Science and Engineering,China West Normal University).Molecular insights into AabZIP1-mediated regulation on artemisinin biosynthesis and drought tolerance in Artemisia annua[J].Acta Pharmaceutica Sinica B,2022,第3期
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Yang Zhou1,Fan Tong1,Weilong Gu1,Siqin He1,Xiaotong Yang1,Jiamei Li1,Yue-Dong Gao2,3,Huile Gao1(Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University;Core Technology Facility of Kunming Institute of Zoology,Chinese Academy of Sciences;Chinese Academy of Sciences Territorial Core Facility of Kunming Biological Diversity Regional Center).Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors[J].Acta Pharmaceutica Sinica B,2022,第3期
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Cutler T.Lewandowski1,Megan S.Laham2,Gregory R.J.Thatcher2(Department of Pharmaceutical Sciences,University of Illinois College of Pharmacy;Department of Pharmacology and Toxicology,University of Arizona College of Pharmacy).Remembering your A, B, C’s:Alzheimer’s disease and ABCA1[J].Acta Pharmaceutica Sinica B,2022,第3期
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Qiang Jin1,Jing Jing Wu2,Yue Wu1,Hongxin Li1,Moshe Finel3,Dandan Wang1,Guangbo Ge1(Shanghai Frontiers Science Center of TCM Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine;Department of Clinical Pharmacology,College of Pharmacy,Dalian Medical University;Division of Pharmaceutical Chemistry and Technology,Faculty of Pharmacy,University of Helsinki).Optical substrates for drug-metabolizing enzymes:Recent advances and future perspectives[J].Acta Pharmaceutica Sinica B,2022,第3期
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Canhao Wu1,2,Qin Xu1,Huiyuan Wang2,Bin Tu2,3,Jiaxin Zeng1,2,Pengfei Zhao2,4,Mingjie Shi2,Hong Qiu2,Yongzhuo Huang2,3,5,6(Artemisinin Research Center,First Clinical School,Guangzhou University of Chinese Medicine;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medic1,Chinese Academy of Sciences;Zhongshan Institute for Drug Discovery,SIMM,CAS;Center of Clinical Pharmacology,The Second Affiliated Hospital of Zhejiang University,School of Medicine;NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients;Taizhou University,School of Advanced Study,Institute of Natural Medicine and Health Product).Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles[J].Acta Pharmaceutica Sinica B,2022,第3期
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Deyan Wu1,2,Xuehua Zheng3,Runduo Liu2,Zhe Li2,Zan Jiang3,Qian Zhou2,Yue Huang2,Xu-Nian Wu2,Chen Zhang2,Yi-You Huang1,2,Hai-Bin Luo1,2(School of Pharmaceutical Sciences,Hainan University;School of Pharmaceutical Sciences,Sun Yat-sen University;School of Pharmaceutical Sciences,Guangzhou Medical University).Free energy perturbation(FEP)-guided scaffold hopping[J].Acta Pharmaceutica Sinica B,2022,第3期
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Bo Zhuang1,2,Ting Chen1,Yueqi Huang1,Zhimei Xiao1,Yiguang Jin1(Department of Pharmaceutical Sciences,Beijing Institute of Radiation Medicine;Department of Chemical Defense,Institute of NBC Defense).Chemo-photothermal immunotherapy for eradication of orthotopic tumors and inhibition of metastasis by intratumoral injection of polydopamine versatile hydrogels[J].Acta Pharmaceutica Sinica B,2022,第3期
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Shiqiao Peng1,Xiaoying Zhang1,Lili Yu2,Yanhong Xu3,Yang Zhou4,Shengnan Qian1,Xinyu Cao1,Xiaotong Ye4,Jiajun Yang3,Weiping Jia1,Jianping Ye1,5,6(Shanghai Diabetes Institute,Shanghai Jiao Tong University Affiliated Sixth People's Hospital;Department of Immunology,School of Basic Medical Sciences,Xinxiang Medical University;Neurology Department,Shanghai Jiao Tong University Affiliated Sixth People's Hospital;National Demonstration Center for Experimental Fisheries Science Education,College of Fisheries and Life Science,Shanghai Ocean University;Metabolic Disease Research Center,Zhengzhou University Affiliated Zhengzhou Central Hospital;Center for Advanced Medicine,College of Medicine,Zhengzhou University).NF-κB regulates brown adipocyte function through suppression of ANT2[J].Acta Pharmaceutica Sinica B,2022,第3期
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Jingyi Li1,2,Yaqi Zhang2,3,Miaorong Yu2,Aohua Wang2,3,Yu Qiu2,3,Weiwei Fan2,Lars Hovgaard4,Mingshi Yang5,Yiming Li1,Rui Wang1,Xiuying Li6,Yong Gan2,3,7(School of Pharmacy,Shanghai University of Traditional Chinese Medicine;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Oral Formulation Development;Department of Pharmacy,Faculty of Health and Medical Sciences,University of Copenhagen;University of Texas at Dallas;NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients,National Institutes for Food and Drug Control).The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery[J].Acta Pharmaceutica Sinica B,2022,第3期
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Kuan Hu1,Wenyu Wu2,Lin Xie1,Hao Geng3,Yiding Zhang1,Masayuki Hanyu1,Lulu Zhang1,Yinghuan Liu3,Kotaro Nagatsu1,Hisashi Suzuki1,Jialin Guo4,Yundong Wu3,5,Zigang Li3,6,Feng Wang2,Mingrong Zhang1(Department of Advanced Nuclear Medicine Sciences,National Institute of Radiological Sciences,National Institutes for Quantum and Radiological Science and Technology;Department of Nuclear Medicin5,Nanjing First Hospital,Nanjing Medical University;State Key Laboratory of Chemical Oncogenomics,the School of Chemical Biology and Biotechnology,Peking University,Shenzhen Graduate School;Rensselaer Polytechnic Institute;Institute of Chemical Biology;Pingshan Translational Medicine Center).Whole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors[J].Acta Pharmaceutica Sinica B,2022,第3期
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Han Xiao1,2,Rui Zhang1,Xiaobo Fan1,Xinglu Jiang1,Mingyuan Zou1,Xuejiao Yan3,Haiping Hao4,Guoqiu Wu5,6(Medical School,Southeast University;Department of Clinical Laboratory,the Fifth Affiliated Hospital of Sun Yat-sen University;Department of Cardiology,the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University;State Key Laboratory of Natural Medicines,Key Lab of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University;Center of Clinical Laboratory Medicine,Zhongda Hospital,Southeast University;Jiangsu Provincial Key Laboratory of Critical Care Medicine,Southeast University).Super-sensitive bifunctional nanoprobe:Self-assembly of peptide-driven nanoparticles demonstrating tumor fluorescence imaging and therapy[J].Acta Pharmaceutica Sinica B,2022,第3期
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Xiaomeng Gao1,Jieqiong You1,Yanling Gong1,Meng Yuan1,2,Haiying Zhu1,Liang Fang3,Hong Zhu1,4,Meidan Ying1,4,Qiaojun He1,2,4,Bo Yang1,2,Ji Cao1,2,4(Institute of Pharmacology and Toxicology,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University;The Innovation Institute for Artificial Intelligence in Medicine,Zhejiang University;Department of Biology,Southern University of Science and Technology;Cancer Center of Zhejiang University).WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit[J].Acta Pharmaceutica Sinica B,2022,第3期
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Yesi Shi1,Hongyan Qian2,Peishi Rao2,Dan Mu1,Yuan Liu2,Gang Liu1,Zhongning Lin1(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University;Department of Rheumatology and Clinical Immunology,The First Affiliated Hospital of Xiamen University).Bioinspired membrane-based nanomodulators for immunotherapy of autoimmune and infectious diseases[J].Acta Pharmaceutica Sinica B,2022,第3期
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Shuhua Shan1,Jinping Niu1,Ruopeng Yin1,Jiangying Shi1,Lizhen Zhang2,Caihong Wu1,Hanqing Li2,Zhuoyu Li1,2(Institute of Biotechnology,Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education,Shanxi University;School of Life Science,Shanxi University).Peroxidase from foxtail millet bran exerts anticolorectal cancer activity via targeting cellsurface GRP78 to inactivate STAT3 pathway[J].Acta Pharmaceutica Sinica B,2022,第3期
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Chenxue Mao1,2,Juan Chen1,2,Ting Zou1,2,Yuankang Zhou1,2,Junyan Liu1,2,Xi Li1,2,Xiangping Li1,Min Li3,Pinhua Pan3,Wei Zhuo1,2,Yang Gao4,Shuo Hu5,Desheng Xiao6,Lin Wu7,Zhan Wang8,Heng Xu9,Wen Yang10,Yingjie Xu10,Haihua Xiao11,Kazuhiko Hanada12,Wei Zhang1,2,Honghao Zhou1,2,Jiye Yin1,2,Zhaoqian Liu1,2(Departments of Clinical Pharmacology and Pharmacy,Hunan Key Laboratory of Pharmacogenetics,and National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University;Institute of Clinical Pharmacology,Engineering Research Center of Applied Technology of Pharmacogenomics,Ministry of Education,Central South University;Department of Respiratory,Xiangya Hospital,Central South University;Department of Thoracic Surgery,Xiangya Hospital,Central South University;Department of Nuclear Medicine,Xiangya Hospital,Central South University;Department of Pathology,Xiangya Hospital,Central South University;Department of Thoracic Medicine,Hunan Cancer Hospital;Department of Medical Oncology,Lung Cancer and Gastrointestinal Unit,Hunan Cancer Hospital;State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University and Collaborative Innovation Center of Biotherapy;Department of Molecular and Cellular Biochemistry,School of Medicine,Shanghai Jiaotong University;Beijing National Laboratory for Molecular Sciences,State Key Laboratory of Polymer Physics and Chemistry,Institute of Chemistry,Chinese Academy of Sciences;Department of Pharmacometrics and Pharmacokinetics Meiji Pharmaceutical University).Genome-wide analysis identify novel germline genetic variations in ADCY1 influencing platinum-based chemotherapy response in nonsmall cell lung cancer[J].Acta Pharmaceutica Sinica B,2022,第3期
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Fengfeng Li1,2,Man Jiang1,2,Minghui Ma1,2,Xuyang Chen1,2,Yidan Zhang1,2,Yixin Zhang1,2,Yuanyuan Yu1,2,Yunfeng Cui1,2,Jiahui Chen1,2,Hui Zhao1,2,Zhijie Sun3,Deli Dong1,2,3(Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China,Key Laboratory of Cardiovascular Research,Ministry of Education),College of Pharmacy,Harbin Medical University;Translational Medicine Research and Cooperation Center of Northern China,Heilongjiang Academy of Medical Sciences,Harbin Medical University;Department of Pharmacology,China Pharmaceutical University).Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice[J].Acta Pharmaceutica Sinica B,2022,第3期
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Min-Xia Su1,Yu-Lian Xu1,Xiao-Ming Jiang1,Mu-Yang Huang1,Le-Le Zhang1,Luo-Wei Yuan1,Xiao-Huang Xu1,Qi Zhu1,Jian-Li Gao2,Jia-Hong Lu1,Xiuping Chen1,Ming-Qing Huang3,Yitao Wang1,Jin-Jian Lu1,4(State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau;School of Pharmaceutical Sciences,Zhejiang Chinese Medical University;College of Pharmacy,Fujian University of Traditional Chinese Medicine;Mo E Frontiers Science Center for Precision Oncology,University of Macau).c-MYC-mediated TRIB3/P62+ aggresomes accumulation triggers paraptosis upon the combination of everolimus and ginsenoside Rh2[J].Acta Pharmaceutica Sinica B,2022,第3期
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Wenhui Tao1,Dongyang Zhao1,Guanting Li1,Lingxiao Li1,Songhao Li1,Hao Ye1,Chutong Tian1,Yutong Lu1,Shuying Li2,Yinghua Sun3,Zhonggui He1,Jin Sun1(Department of Pharmaceutics,Wuya College of Innovation,Shenyang Pharmaceutical University;Department of Pharmaceutical and Engineering,College of Pharmaceutical and Engineering,Shenyang Pharmaceutical University;Department of Pharmaceutics,College of Pharmacy,Shenyang Pharmaceutical University).Artificial tumor microenvironment regulated by first hemorrhage for enhanced tumor targeting and then occlusion for synergistic bioactivation of hypoxia-sensitive platesomes[J].Acta Pharmaceutica Sinica B,2022,第3期
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Fangyu Du1,Ruolin Cao1,Lu Chen1,Jianwen Sun1,Yajie Shi1,Yang Fu1,Bruce D.Hammock2,Zhonghui Zheng3,Zhongbo Liu4,Guoliang Chen1(Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education,School of Pharmaceutical Engineering,Shenyang Pharmaceutical University;Department of Entomology and Nematology and UC Davis Comprehensive Cancer Center,University of California Davis;Shandong Xinhua Pharmaceutical Co.,Ltd.;School of Pharmacy,Shenyang Pharmaceutical University).Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain[J].Acta Pharmaceutica Sinica B,2022,第3期
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Ying Zhang1,Tao Wang1,Xiaojun Zhang2,Winnie Deuther-Conrad3,Hualong Fu1,Mengchao Cui1,Jinming Zhang2,Peter Brust3,4,Yiyun Huang5,Hongmei Jia1(Key Laboratory of Radiopharmaceuticals (Beijing Normal University),Ministry of Education,College of Chemistry,Beijing Normal University;Nuclear Medicine Department,Chinese PLA General Hospital;Helmholtz-Zentrum Dresden-Rossendorf,Institute of Radiopharmaceutical Cancer Research,Department of Neuroradiopharmaceuticals;The Lübeck Institute of Experimental Dermatology,University Medical Center Schleswig-Holstein;PET Center,Department of Radiology and Biomedical Imaging,Yale University School of Medicine).Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors[J].Acta Pharmaceutica Sinica B,2022,第3期
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Wei Xie1,Shuanghuan Liu2,Guanqiao Li3,Huiyan Xu1,Liyun Zhou1(Pharmcube (Beijing) Co.,Ltd.;National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;Tsinghua Clinical Research Institute (TCRI),School of Medicine,Tsinghua University).The evolving treatment paradigm of lung cancer in China[J].Acta Pharmaceutica Sinica B,2022,第3期
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Peng Teng1,Jianfeng Cai2(College of Pharmaceutical Sciences,Zhejiang University;Department of Chemistry,University of South Florida).Using proteomimetics to switch angiogenic signaling[J].Acta Pharmaceutica Sinica B,2022,第3期
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