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Na Kong1,2,Xiaying Chen1,3,Jiao Feng1,3,Ting Duan1,3,Shuiping Liu1,3,Xueni Sun1,3,Peng Chen1,3,Ting Pan1,3,Lili Yan1,3,Ting Jin1,3,Yu Xiang1,3,Quan Gao1,3,Chengyong Wen1,3,Weirui Ma1,3,Wencheng Liu1,3,Mingming Zhang1,3,Zuyi Yang1,3,Wengang Wang1,3,Ruonan Zhang1,3,Bi Chen1,3,Tian Xie1,3,Xinbing Sui1,3,Wei Tao2(College of Pharmacy and Department of Medical Oncology,the Affiliated Hospital of Hangzhou Normal University,School of Medicine,Hangzhou Normal University;Center for Nanomedicine and Department of Anesthesiology,Brigham and Women's Hospital,Harvard Medical School;Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines,Engineering Laboratory of Development and Application of Traditional Chinese Medicines,Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province,Hangzhou Normal University).Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1[J].Acta Pharmaceutica Sinica B,2021,第12期
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Yancheng Tang1,Liming Wang2,3,Tao Yi1,Jun Xu1,Jigang Wang4,5,Jiang-Jiang Qin6,Qilei Chen1,Ka-Man Yip1,Yihang Pan7,Peng Hong7,Yingying Lu7,8,Han-Ming Shen3,9,Hu-Biao Chen1(School of Chinese Medicine,Hong Kong Baptist University;School of Biomedical Sciences,Hunan University;Department of Physiology,Yong Loo Lin School of Medicine,National University of Singapore;Artemisinin Research Center,China Academy of Chinese Medical Sciences;The First Affiliated Hospital of Southern University of Science and Technology,the Second Clinical Medical College of Jinan University,Shenzhen People's Hospital;The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital),Institute of Basic Medicine and Cancer (IBMC),Chinese Academy of Sciences;Department of Medical Research,Seventh Affiliated Hospital,Sun Yat-sen University;Department of Biomedical Science,City University of Hong Kong;Faculty of Health Sciences,University of Macau).Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy[J].Acta Pharmaceutica Sinica B,2021,第12期
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Hartmut Jaeschke,Olamide B.Adelusi,Jephte Y.Akakpo,Nga T.Nguyen,Giselle Sanchez-Guerrero,David S.Umbaugh,Wen-Xing Ding,Anup Ramachandran(Department of Pharmacology,Toxicology & Therapeutics,University of Kansas Medical Center).Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls[J].Acta Pharmaceutica Sinica B,2021,第12期
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Layla Shojaie1,2,Myra Ali3,rea Iorga1,2,4,5,Lily Dara1,2(Division of Gastrointestinal and Liver Diseases,Department of Medicine,Keck School of Medicine,University of Southern California;Research Center for Liver Disease,Keck School of Medicine,University of Southern California;Keck School of Medicine,University of Southern California;U.S.Food and Drug Administration,Center for Devices and Radiological Health;UMBC Center for Accelerated Real Time Analytics,University of Maryland,Baltimore County).Mechanisms of immune checkpoint inhibitormediated liver injury[J].Acta Pharmaceutica Sinica B,2021,第12期
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Zheng Su1,2,Dian Xiao2,Fei Xie2,Lianqi Liu2,Yanming Wang2,Shiyong Fan2,Xinbo Zhou2,Song Li1,2(School of Pharmaceutical Engineering, Shenyang Pharmaceutical University;National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology).Antibody-drug conjugates:Recent advances in linker chemistry[J].Acta Pharmaceutica Sinica B,2021,第12期
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Daniel Rizzolo1,2,3,Bo Kong1,Rulaiha E.Taylor1,Anita Brinker2,Michael Goedken4,Brian Buckley1,2,Grace L.Guo1,2,3,5(Department of Pharmacology and Toxicology,School of Pharmacy,Rutgers University;Environmental and Occupational Health Institute,Rutgers University;Rutgers Center of Lipid Research,Rutgers University;Office of Research and Economic Development,Research Pathology Services,Rutgers University;Department of Veterans Affairs New Jersey Health Care System).Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1[J].Acta Pharmaceutica Sinica B,2021,第12期
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Antonio Segovia-Zafra1,2;Daniel E.Di Zeo-Sánchez1;Carlos López-Gómez3;Zeus Prez-Valdés1;Eduardo García-Fuentes3;Raúl J.Andrade1,2;M.Isabel Lucena1,2,4;Marina Villanueva-Paz1(Unidad de Gestión Clínica de Gastroenterología, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga;Centro de Investigación Biomédica en Red en el área Temática de Enfermedades Hepáticas y Digestivas (CIBERehd);Unidad de Gestión Clínica de Aparato Digestivo, Instituto de Investigación Biomédica de Málaga (IBIMA),Hospital Universitario Virgen de la Victoria;Platform ISCⅢ de Ensayos Clínicos,UICEC-IBIMA).Preclinical models of idiosyncratic drug-induced liver injury(iDILI):Moving towards prediction[J].Acta Pharmaceutica Sinica B,2021,第12期
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Meijia Qian1,Fangjie Yan2,Weihua Wang1,Jiamin Du1,Tao Yuan1,Ruilin Wu1,Chenxi Zhao1,Jiao Wang1,Jiabin Lu1,Bo Zhang3,Nengming Lin3,Xin Dong4,Xiaoyang Dai1,Xiaowu Dong1,Bo Yang1,Hong Zhu1,3,5,Qiaojun He1,2,4,5(Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University;Innovation Institute for Artificial Intelligence in Medicine,Zhejiang University;Department of Clinical Pharmacology,Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,Affiliated Hangzhou First People's Hospital,Cancer Center,Zhejiang University School of Medicine;Second Affiliated Hospital,School of Medicine,Zhejiang University;Cancer Center of Zhejiang University).Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression[J].Acta Pharmaceutica Sinica B,2021,第12期
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Melissa M.Clemens1,2,Stefanie Kennon-McGill3,Joel H.Vazquez1,2,Owen W.Stephens4,Erich A.Peterson4,Donald J.Johann4,Felicia D.Allard5,Eric U.Yee5,Sandra S.McCullough6,Laura P.James6,Brian N.Finck7,Mitchell R.McGill1,3,8(Department of Pharmacology and Toxicology,College of Medicine,University of Arkansas for Medical Sciences;Interdisciplinary Graduate Program in Biomedical Sciences,Graduate School,University of Arkansas for Medical Sciences;Department of Environmental and Occupational Health,Fay W.Boozman College of Public Health,University of Arkansas for Medical Sciences;Winthrop P.Rockefeller Cancer Institute,University of Arkansas for Medical Sciences;Department of Pathology,Renaissance School of Medicine,Stony Brook University;Department of Pediatrics,College of Medicine,University of Arkansas for Medical Sciences;Division of Geriatrics and Nutritional Sciences,Department of Internal Medicine,Washington University School of Medicine;Center for Dietary Supplement Research,University of Arkansas for Medical Sciences).Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk[J].Acta Pharmaceutica Sinica B,2021,第12期
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Hui Qian1,Qingyun Bai1,2,3,Xiao Yang1,2,Jephte Y.Akakpo1,Lili Ji1,Li Yang2,Thomas Rülicke4,Kurt Zatloukal5,Hartmut Jaeschke1,Hong-Min Ni1,Wen-Xing Ding1(Department of Pharmacology,Toxicology and Therapeutics,University of Kansas Medical Center;The MOE Key Laboratory for Standardization of Chinese Medicines,Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine;School of Chemistry and Bioengineering,Yichun University;Department of Biomedical Sciences,University of Veterinary Medicine Vienna Veterin?rplatz;The Institute of Pathology,Medical University of Graz).Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice[J].Acta Pharmaceutica Sinica B,2021,第12期
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Juliane I.Beier1,2,3,Gavin E.Arteel1,2(Department of Medicine,Division of Gastroenterology,Hepatology and Nutrition,University of Pittsburgh;Pittsburgh Liver Research Center and University of Pittsburgh;Department of Environmental and Occupational Health,University of Pittsburgh).Environmental exposure as a risk-modifying factor in liver diseases:Knowns and unknowns[J].Acta Pharmaceutica Sinica B,2021,第12期
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Gundala Venkata Naveen Kumar1,Keito Hoshitsuki1,2,Sanjay Rathod1,Manda J.Ramsey1,Lauren Kokai3,Erin E.Kershaw4,Wen Xie1,Christian A.Fernandez1(Department of Pharmaceutical Sciences and Center for Pharmacogenetics,University of Pittsburgh School of Pharmacy;Division of General Internal Medicine,University of Pittsburgh School of Medicine;Department of Plastic Surgery,University of Pittsburgh and the Mc Gowan Institute for Regenerative Medicine;University of Pittsburgh,Division of Endocrinology,Department of Medicine).Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice[J].Acta Pharmaceutica Sinica B,2021,第12期
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Joseph L.Jilek1,Kayla L.Frost1,Kevyn A.Jacobus1,Wenxi He1,Erica L.Toth1,Michael Goedken2,Nathan J.Cherrington1(Department of Pharmacology & Toxicology,College of Pharmacy,University of Arizona;Rutgers Translational Sciences,Rutgers University).Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity[J].Acta Pharmaceutica Sinica B,2021,第12期
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Zinuo Chen1,Ruikun Du1,2,3,Jazmin M.Galvan Achi4,Lijun Rong4,Qinghua Cui1,2,3(College of Pharmacy,Shandong University of Traditional Chinese Medicine;Qingdao Academy of Chinese Medicinal Sciences,Shandong University of Traditional Chinese Medicine;Experimental Center,Shandong University of Traditional Chinese Medicine;Department of Microbiology and Immunology,College of Medicine,University of Illinois at Chicago).SARS-CoV-2 cell entry and targeted antiviral development[J].Acta Pharmaceutica Sinica B,2021,第12期
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Jian Jin1,2,Banrida Wahlang3,4,Monika Thapa5,Kimberly Z.Head3,Josiah E.Hardesty3,Sudhir Srivastava6,7,Michael L.Merchant8,9,10,Shesh N.Rai4,6,8,10,11,12,Russell A.Prough5,Matthew C.Cave1,3,4,5,8,10,11(Department of Pharmacology & Toxicology,the University of Louisville School of Medicine;Department of Endocrinology,the Second Affiliated Hospital & Yuying Children's Hospital,Wenzhou Medical University;Division of Gastroenterology,Hepatology & Nutrition,Department of Medicine,the University of Louisville School of Medicine;Superfund Research Center,the University of Louisville;Department of Biochemistry and Molecular Genetics,the University of Louisville School of Medicine;Department of Bioinformatics and Biostatistics,the School of Public Health and Information Sciences,the University of Louisville;Centre for Agricultural Bioinformatics,ICAR-Indian Agricultural Statistics Research Institute;The Center for Integrative Environmental Health Sciences,University of Louisville;Division of Nephrology & Hypertension,Department of Medicine,the University of Louisville School of Medicine;The Hepatobiology and Toxicology Center,University of Louisville;Alcohol Research Center,University of Louisville;Biostatistics and Bioinformatics Facility,James Graham Brown Cancer Center).Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver[J].Acta Pharmaceutica Sinica B,2021,第12期
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Hua Sang1,2,Jiali Liu1,Fang Zhou1,Xiaofang Zhang1,Jingwei Zhang1,Yazhong Liu1,Guangji Wang1,Hui Ye1(Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics,State Key Laboratory of Natural Medicines,China Pharmaceutical University;Department of Pharmacy,the Affiliated Hospital of Nantong University).Target-responsive subcellular catabolism analysis for early-stage antibody-drug conjugates screening and assessment[J].Acta Pharmaceutica Sinica B,2021,第12期
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Linglong Deng1,2,Hannah Petrek2,Mei-Juan Tu2,Neelu Batra2,Ai-Xi Yu1,Ai-Ming Yu2(Department of Orthopaedic Trauma and Microsurgery,Zhongnan Hospital of Wuhan University;Department of Biochemistry and Molecular Medicine,UC Davis School of Medicine).Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo[J].Acta Pharmaceutica Sinica B,2021,第12期
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Yisheng He1,Jiang Ma1,Xiaoyu Fan2,Liang Ding2,Xinxin Ding2,Qing-Yu Zhang2,Ge Lin1(School of Biomedical Sciences,Faculty of Medicine,the Chinese University of Hong Kong;Department of Pharmacology & Toxicology,College of Pharmacy,University of Arizona).The key role of gut-liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity[J].Acta Pharmaceutica Sinica B,2021,第12期
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Ting Lei1,Zhihang Yang1,Xue Xia1,Yuxiu Chen1,Xiaotong Yang1,Rou Xie1,Fan Tong1,Xiaolin Wang2,Huile Gao1(Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University;School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine,Macau University of Science and Technology).A nanocleaner specifically penetrates the blood-brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer’s disease[J].Acta Pharmaceutica Sinica B,2021,第12期
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Zhihao Fu1,Hongchuan Liu2,Lan Wang1,Chuanfei Yu1,Yalan Yang1,Meiqing Feng2,Junzhi Wang1(Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products,National Institutes for Food and Drug Control;Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics,School of Pharmacy,Fudan University).A reporter gene assay for determining the biological activity of therapeutic antibodies targeting TIGIT[J].Acta Pharmaceutica Sinica B,2021,第12期
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Huaqing Zhengy,Xiaolong Liy,Xin Zeng,Chengcui Huang,Mingming Ma,Xiaofei Lv,Yajuan Zhang,Lu Sun,Guanlei Wang,Yanhua Du,Yongyuan Guan(Department of Pharmacology,Cardiac & Cerebral Vascular Research Center,Zhongshan School of Medicine,Sun Yat-sen University).TMEM16A inhibits angiotensin Ⅱ-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner[J].Acta Pharmaceutica Sinica B,2021,第12期
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Valeria Marrocco,Tuan Tran,Siying Zhu,Seung Hyuk Choi,Ana M.Gamo,Sijia Li,Qiangwei Fu,Marta Diez Cunado,Jason Roland,Mitch Hull,Van Nguyen-Tran,Sean Joseph,Arnab K.Chatterjee,Nikki Rogers,Matthew S.Tremblay,Weijun Shen(Calibr at Scripps Research,The Scripps Research Institute).A small molecule UPR modulator for diabetes identified by high throughput screening[J].Acta Pharmaceutica Sinica B,2021,第12期
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Meng Liu,Shan Gao,Reham M.Elhassan,Xuben Hou,Hao Fang(School of Pharmaceutical Sciences,Cheeloo College of Medicine,Shandong University).Strategies to overcome drug resistance using SHP2 inhibitors[J].Acta Pharmaceutica Sinica B,2021,第12期
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Regina D.Schnegelberger1,Anna L.Lang2,Gavin E.Arteel3,4,Juliane I.Beier3,4,5(Department of Pharmacology & Chemical Biology,University of Pittsburgh;Department of Neurology,University of Miami Miller School of Medicine;Department of Medicine,Division of Gastroenterology,Hepatology & Nutrition,University of Pittsburgh;Pittsburgh Liver Research Center,University of Pittsburgh;Department of Environmental & Occupational Health,University of Pittsburgh).Environmental toxicant-induced maladaptive mitochondrial changes:A potential unifying mechanism in fatty liver disease?[J].Acta Pharmaceutica Sinica B,2021,第12期
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Manni Wangy,Siyuan Cheny,Yuquan Wei,Xiawei Wei(Laboratory of Aging Research and Cancer Drug Target,State Key Laboratory of Biotherapy and Cancer Center,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University).DNA-PK inhibition by M3814 enhances chemosensitivity in non-small cell lung cancer[J].Acta Pharmaceutica Sinica B,2021,第12期
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Payal Rana1,Michael D.Aleo1,Xuerong Wen2,Stephen Kogut2(Drug Safety Research & Development;University of Rhode Island,College of Pharmacy).Hepatotoxicity reports in the FDA adverse event reporting system database:A comparison of drugs that cause injury via mitochondrial or other mechanisms[J].Acta Pharmaceutica Sinica B,2021,第12期
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