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Keliang Chen1,Tao Wang2,Yong Li1,Jun Wu1,Cheng-Xiao Zhao1,Sheng Liu1,Fengrun Sun2,Yehong Fang2,Jiahuan Hu1,Jinping Hu1,Chong-Jing Zhang1,Haibo Yu1,Chao Ma2,Shi-Shan Yu1(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Institute of Basic Medical Sciences,Neuroscience Center,Chinese Academy of Medical Sciences,Department of Human Anatomy,Histology and Embryology,School of Basic Medicine,Peking Union Medical College).Rhodojaponin Ⅵ indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain[J].Acta Pharmaceutica Sinica B,2023,第3期
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Shiyang Shen,Teng Li,Jinyi Fan,Quanlin Shao,He Dong,Xiao Xu,Ran Mo(State Key Laboratory of Natural Medicines,Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases,Center of Advanced Pharmaceuticals and Biomaterials,School of Life Science and Technology,China Pharmaceutical University).Lipid-polymer hybrid nanoparticle with cell-distinct drug release for treatment of stemness-derived resistant tumor[J].Acta Pharmaceutica Sinica B,2023,第3期
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Juanjuan Feng1,2,Zhengke Lian1,Xinting Xia1,Yue Lu1,Kewen Hu3,Yunpeng Zhang1,Yanan Liu1,Longmiao Hu1,Kun Yuan1,Zhenliang Sun2,Xiufeng Pang1(Shanghai Key Laboratory of Regulatory Biology,School of Life Sciences,East China Normal University;Joint Center for Translational Medicine,Southern Medical University Affiliated Fengxian Hospital;Cancer Institute,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University).Targeting metabolic vulnerability in mitochondria conquers MEK inhibitor resistance in KRAS-mutant lung cancer[J].Acta Pharmaceutica Sinica B,2023,第3期
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Xin Jin1,2,3,Shuai Wang1,2,Limin Zhao1,2,3,Wenjuan Huang1,2,Yinxiang Zhang1,2,Christophe Pannecouque4,Erik De Clercq4,Ge Meng1,2,Huri Piao3,Fener Chen1,2,3(Engineering Center of Catalysis and Synthesis for Chiral Molecules,Department of Chemistry,Fudan University;Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs;Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules,Ministry of Education,College of Pharmacy,Yanbian University;Rega Institute for Medical Research,KU Leuven).Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors:Boosting the safety and metabolic stability[J].Acta Pharmaceutica Sinica B,2023,第3期
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Ling-Ling Wu1,2,3,Qinxin Zhao1,2,3,Qinghua Wang1,Qingyang Zhang1,Feiya Yang2,3,Bo Zheng4,Hai-Yu Hu1,Nianzeng Xing2,3,5(State Key Laboratory of Bioactive Substances and Function of Natural Medicine,Institute of Materia Medica,Peking Union Medical College and Chinese Academy of Medical Sciences;Department of Urology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;Department of Pathology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;Department of Urology,Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital,Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University).Membrane dual-targeting probes:A promising strategy for fluorescence-guided prostate cancer surgery and lymph node metastases detection[J].Acta Pharmaceutica Sinica B,2023,第3期
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Jiang Wu1,Wenfeng Gou2,Zhiyun Wang3,Huajie Chang3,Deguan Li2,Wenbin Hou2,Changxiao Liu4(Department of Pharmaceutical Engineering,School of Chemical Engineering and Technology,Tianjin University;Institute of Radiation Medicine,Chinese Academy of Medical Sciences;School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine;Research Center for New Drug Evaluation,the State Laboratory of Drug Delivery Technology and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research).Discovery of the radio-protecting effect of Ecliptae Herba,its constituents and targeting p53-mediated apoptosis in vitro and in vivo[J].Acta Pharmaceutica Sinica B,2023,第3期
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Tengjie Yu1,Zhihao Zhou1,Shijia Liu2,Changjian Li1,Zhi-Wei Zhang3,Yong Zhang3,Wei Jin1,Keanqi Liu1,Shuying Mao1,Lei Zhu2,Lin Xie1,Guangji Wang1,Yan Liang1(Key Lab of Drug Metabolism & Pharmacokinetics,State Key Laboratory of Natural Medicines,China Pharmaceutical University;Affliated Hospital of Nanjing University of Chinese Medicine;College of Chemical & Pharmaceutical Engineering,Hebei University of Science & Technology).The role of phosphatidylcholine 34:1 in the occurrence,development and treatment of ulcerative colitis[J].Acta Pharmaceutica Sinica B,2023,第3期
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Xueqin Huang,Bingbing Sheng,Hemi Tian,Qiuxia Chen,Yingqi Yang,Brian Bui2,Jiang Pi3,Huaihong Cai3,Shanze Chen,Jianglin Zhang,Wei Chen2,Haibo Zhou,Pinghua Sun(The Second Clinical Medical College (Shenzhen People’s Hospital),College of Pharmacy,Jinan University;Department of Physics,the University of Texas at Arlington;Department of Chemistry,Jinan University).Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy[J].Acta Pharmaceutica Sinica B,2023,第3期
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Qunjie Bi1,Xu Song2,Yangyang Zhao1,Xueyi Hu1,Huan Yang1,Rongrong Jin1,Yu Nie1(National Engineering Research Center for Biomaterials,College of Biomedical Engineering,Sichuan University;NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial & Institute of Regulatory Science for Medical Devices & NMPA Research Base of Regulatory Science for Medical Devices,Sichuan University).Mucus-penetrating nonviral gene vaccine processed in the epithelium for inducing advanced vaginal mucosal immune responses[J].Acta Pharmaceutica Sinica B,2023,第3期
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Zhuo Feng1,Yuchen Wang1,Haiheng Xu1,Yunfei Guo1,Wen Xia1,Chenxuan Zhao1,Xiaozhi Zhao2,Jinhui Wu1,3(State Key Laboratory of Pharmaceutical Biotechnology,Chemistry and Biomedicine Innovation Center,Medical School of Nanjing University;Department of Andrology,Drum Tower Hospital,Medical School of Nanjing University;Jiangsu Key Laboratory for Nano Technology,Nanjing University).Recent advances in bacterial therapeutics based on sense and response[J].Acta Pharmaceutica Sinica B,2023,第3期
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Lu Zhang1,Xiaolei Zhou2,Bowen Liu3,Xuhe Shi1,Xianmeng Li1,Feifei Xu1,Xueli Fu1,Xue Wang1,Kai Ye1,Tianzhi Jin1,Huimin Sun1,Qianqian Li1,Weiying Zhang1,Lihong Ye1(State Key Laboratory of Medicinal Chemical Biology,Tianjin Key Laboratory of Protein Sciences,Department of Biochemistry and Molecular Biology,College of Life Sciences,Nankai University;College of Food Science & Biology,Hebei University of Science and Technology;Henan Key Laboratory of Immunology and Targeted Drugs,School of Laboratory Medicine,Xinxiang Medical University).HBXIP blocks myosin-ⅡA assembly by phosphorylating and interacting with NMHC-ⅡA in breast cancer metastasis[J].Acta Pharmaceutica Sinica B,2023,第3期
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Minxuan Xu1,2,3,Jun Tan1,2,Liancai Zhu3,Chenxu Ge1,2,3,Wei Dong4,Xianling Dai1,3,Qin Kuang1,3,Shaoyu Zhong1,2,Lili Lai1,2,Chao Yi1,2,Qiang Li1,2,Deshuai Lou1,2,Linfeng Hu1,2,3,Xi Liu1,2,Gang Kuang1,2,Jing Luo1,2,Jing Feng3,Bochu Wang3(Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region,School of Biological and Chemical Engineering,Chongqing University of Education;College of Modern Health Industry,Chongqing University of Education;Key Laboratory of Biorheological Science and Technology (Chongqing University),Ministry of Education,College of Bioengineering,Chongqing University;Shandong Cancer Hospital and Institute,Shandong First Medical University & Shandong Academy of Medical Sciences).The deubiquitinating enzyme 13 retards non-alcoholic steatohepatitis via blocking inactive rhomboid protein 2-dependent pathway[J].Acta Pharmaceutica Sinica B,2023,第3期
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Sae-Bom Yoon1,2,Hyowon Hong1,Hee-Jong Lim1,Ji Hye Choi1,Yoon Pyo Choi3,Seong Wook Seo3,Hyuk Woo Lee3,Chong Hak Chae1,Woo-Kyu Park1,Hyun Young Kim1,Daeyoung Jeong1,Tran Quang De1,Chang-Seon Myung2,Heeyeong Cho1(Therapeutics & Biotechnology Division,Korea Research Institute of Chemical Technology;Department of Pharmacology,Chungnam National University College of Pharmacy;Future Medicine Co.Ltd.Rm616 LH-Business Growth Center).A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway[J].Acta Pharmaceutica Sinica B,2023,第3期
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Mengyao Hao1,Rong Fu1,Jun Tai,Zhenhuan Tian3,Xia Yuan4,Yang Chen5,Mingjin Wang1,Huimin Jiang1,Ming Ji1,Fangfang Lai1,Nina Xue1,Liping Bai6,Yizhun Zhu6,Xiaoxi Lv1,Xiaoguang Chen1,Jing Jin1(State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences,Peking Union Medical College;Department of Otolaryngology,Head and Neck Surgery,Children’s Hospital Capital Institute of Pediatrics;Department of Thoracic Surgery,Peking Union Medical College Hospital,Peking Union Medical College;State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University;Department of Pharmacology,School of Pharmaceutical,Guangzhou University of Chinese Medicine;State Key Laboratory of Quality Research in Chinese Medicine,Macau Institute for Applied Research in Medicine and Health,Macau University of Science and Technology).S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung[J].Acta Pharmaceutica Sinica B,2023,第3期
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Xiaoli Wei1,Fan Yin2,3,Miaomiao Wu1,3,Qianqian Xie3,4,Xueqin Zhao3,4,Cheng Zhu1,Ruiqian Xie3,4,Chongqing Chen3,4,Menghua Liu3,4,Xueying Wang1,Ruixue Ren1,Guijie Kang3,4,Chenwen Zhu1,Jingjing Cong3,4,Hua Wang1,4,Xuefu Wang3,4(Department of Oncology,the First Affiliated Hospital of Anhui Medical University;Department of Pharmacy,Huainan First People's Hospital,the First Affiliated Hospital of Anhui University of Science and Technology;School of Pharmacy,Anhui Medical University;Inflammation and Immune Mediated Diseases Laboratory of Anhui Province,Anhui Medical University).G protein-coupled receptor 35 attenuates nonalcoholic steatohepatitis by reprogramming cholesterol homeostasis in hepatocytes[J].Acta Pharmaceutica Sinica B,2023,第3期
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Ning Shao1,Xueyang Ma2,Ying-Ying Zhang1,Donghui Yang2,Ming Ma2,Gong-Li Tang1,3(State Key Laboratory of Bioorganic and Natural Products Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences;State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University;School of Chemistry and Materials Science Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences).Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis[J].Acta Pharmaceutica Sinica B,2023,第3期
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Geni Ye,Maohua Huang,Yong Li,Jie Ouyang,Minfeng Chen,Qing Weng,Xiaobo Li,Huhu Zeng,Pei Long,Zepei Fan,Junqiang Yin,Wencai Ye,Dongmei Zhang(College of Pharmacy;Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research;Integrated Chinese and Western Medicine Postdoctoral Research Station;Department of Musculoskeletal Oncology).Author correction to“The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway”[Acta Pharm Sin B 12(2022)1288–1304][J].药学学报(英文版),2023,第3期
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Huaqing Zheng,Xiaolong Li,Xin Zeng,Chengcui Huang,Mingming Ma,Xiaofei Lv,Yajuan Zhang,Lu Sun,Guanlei Wang,Yanhua Du,Yongyuan Guan(Department of Pharmacology).Author correction to“TMEM16A inhibits angiotensin Ⅱ-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner”[Acta Pharm Sin B 11(12)(2021)3994–4007][J].药学学报(英文版),2023,第3期
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(Editoral Office of Acta Pharmaceutica Sinica).Information for Authors[J].Acta Pharmaceutica Sinica B,2023,第3期
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Haowen Xu1,2,Jiahao Chen1,Pan Chen1,Weifeng Li1,Jingjing Shao1,2,Shanshan Hong1,Yi Wang1,Lingfeng Chen2,Wu Luo1,3,Guang Liang1,2(Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University;School of Pharmaceutical Sciences,Hangzhou Medical College;Medical Research Center,the First Affiliated Hospital of Wenzhou Medical University).Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases[J].Acta Pharmaceutica Sinica B,2023,第2期
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Ze Mi1,Qing Yao1,2,3,Yan Qi2,Jinhai Zheng4,Jiahao Liu1,Zhenguo Liu1,Hongpei Tan1,Xiaoqian Ma1,Wenhu Zhou1,5,6,Pengfei Rong1,6(Department of Radiology,The Third Xiangya Hospital,Central South University;Department of Pathology,Shihezi University School of Medicine and the First Affiliated Hospital to Shihezi University School of Medicine;Department of Pathology,Cangzhou Central Hospital&the Affiliated to Hebei Medical University;School of Biomedical Sciences,Hunan University;Xiangya School of Pharmaceutical Sciences,Central South University;Key Laboratory of Biological Nanotechnology of National Health Commission).Salmonella-mediated blood-brain barrier penetration, tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy[J].Acta Pharmaceutica Sinica B,2023,第2期
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Huaan Li1,2,Fei Peng3,Xiaohui Yan4,Chun Mao5,Xing Ma6,Daniela A.Wilson7,Qiang He8,Yingfeng Tu1,2(Department of Pharmacy,Zhujiang Hospital,Southern Medical University;School of Pharmaceutical Science,Guangdong Provincial Key Laboratory of New Drug Screening,Southern Medical University;School of Materials Science and Engineering,Sun Yat-Sen University;State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Centre for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University;National and Local Joint Engineering Research Center of Biomedical Functional Materials,School of Chemistry and Materials Science,Nanjing Normal University;Sauvage Laboratory for Smart Materials,School of Materials Science and Engineering,Harbin Institute of Technology(Shenzhen);Institute for Molecules and Materials,Radboud University;Key Laboratory of Microsystems and Microstructures Manufacturing(Ministry of Education),School of Medicine and Health,Harbin Institute of Technology).Medical micro-and nanomotors in the body[J].Acta Pharmaceutica Sinica B,2023,第2期
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Yujun Zhou1,Jingshu Tang1,Jiaqi Lan1,Yong Zhang1,Hongyue Wang1,Qiuyu Chen1,Yuying Kang1,Yang Sun2,Xinhong Feng3,Lei Wu1,Hongtao Jin4,5,Shizhong Chen2,Ying Peng1(State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College;Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University;Department of Neurology,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University;New Drug Safety Evaluation Center,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College;NMPA Key Laboratory for Safety Research and Evaluation of Innovative Drug).Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis[J].Acta Pharmaceutica Sinica B,2023,第2期
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Yeuan Ting Lee,Yi Jer Tan,Chern Ein Oon(Institute for Research in Molecular Medicine (INFORMM),Universiti Sains Malaysia).Benzimidazole and its derivatives as cancer therapeutics:The potential role from traditional to precision medicine[J].Acta Pharmaceutica Sinica B,2023,第2期
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Chen Fu1,2,Lifeng Yu1,Yuxi Miao1,2,3,Xinli Liu4,Zhaojin Yu1,2,Minjie Wei1,2,3(Department of Pharmacology,School of Pharmacy,China Medical University;Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation,China Medical University;Liaoning Medical Diagnosis and Treatment Center;Department of Digestive Oncology,Cancer Hospital of China Medical University,Liaoning Cancer Hospital&Institute).Peptide-drug conjugates(PDCs):a novel trend of research and development on targeted therapy, hype or hope?[J].Acta Pharmaceutica Sinica B,2023,第2期
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Jizhou Tan1,2,Ting Liu3,4,Wenzhe Fan1,Jialiang Wei1,Bowen Zhu1,Yafang Liu2,Lingwei Liu1,Xiaokai Zhang1,Songling Chen2,Haibiao Lin3,4,Yuanqing Zhang5,Jiaping Li1(Department of Interventional Oncology,the First Affiliated Hospital,Sun Yat-sen University;Department of Stomatology,the First Affiliated Hospital,Sun Yat-sen University;Department of Laboratory Medicine,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong Provincial Hospital of Traditional,Chinese Medicine;Second Clinical Medical College,Guangzhou University of Chinese Medicine;School of Pharmaceutical Sciences,Sun Yat-sen University).Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1highCD11b+cells elimination in hepatocellular carcinoma[J].Acta Pharmaceutica Sinica B,2023,第2期
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Zhengjie Lu1,2,Yu Guo1,3,Dan Xu1,3,Hao Xiao2,3,Yongguo Dai1,Kexin Liu1,Liaobin Chen2,3,Hui Wang1,3(Department of Pharmacology,Wuhan University School of Basic Medical Science;Department of Orthopedic Surgery,Zhongnan Hospital of Wuhan University;Hubei Provincial Key Laboratory of Developmentally Originated Disorder).Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy[J].Acta Pharmaceutica Sinica B,2023,第2期
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Lujing Geng1,Tong Lu2,Huaqing Jing1,Yue Zhou1,Xiaoyang Liang1,Jiao Li2,Nan Li1(Tianjin Key Laboratory of Drug Delivery&High-Efficiency,School of Pharmaceutical Science and Technology,Tianjin University;School of Precision Instruments and Optoelectronics Engineering,Tianjin University).Iron-based and BRD4-downregulated strategy for amplified ferroptosis based on pH-sensitive/NIR-Ⅱ-boosted nano-matchbox[J].Acta Pharmaceutica Sinica B,2023,第2期
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Jianjun Cheng1,2,3,Haitian Zhao1,4,5,Bin Li6,Hua Zhang2,Qianyu Zhao1,2,Shiyao Fu1,2,Ying Han1,2,Weihong Lu1,4,5,Jiahua Shi3,Xin Yang1,2,4,5(School of Medicine and Health,Harbin Institute of Technology;School of Chemistry and Chemical Engineering,Harbin Institute of Technology;Key Laboratory of Natural Medicine and Immune-Engineering of Henan Province,Henan University;Chongqing Research Institute,Harbin Institute of Technology;National and Local Joint Engineering Laboratory for Synthesis,Transformation and Separation of Extreme Environmental Nutrients;Academician Workstation,Jiangxi University of Chinese Medicine).Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy[J].Acta Pharmaceutica Sinica B,2023,第2期
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