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Lingling Zhang1,2,Kuan Hu3,Tuo Shao4,Lu Hou1,Shaojuan Zhang1,Weijian Ye1,Lee Josephson4,Jeffrey H.Meyer5,Ming-Rong Zhang3,Neil Vasdev4,5,Jinghao Wang6,Hao Xu1,Lu Wang1,4,Steven H.Liang4(Center of Cyclotron and PET Radiopharmaceuticals,Department of Nuclear Medicine and PET/CT-MRI Center,The First Affiliated Hospital of Jinan University;Department of Neurology,the First Affiliated Hospital of Jinan University;Department of Radiopharmaceuticals Development,National Institute of Radiological Sciences,National Institutes for Quantum and Radiological Science and Technology;Division of Nuclear Medicine and Molecular Imaging,Massachusetts General Hospital & Department of Radiology,Harvard Medical School;Azrieli Centre for Neuro-Radiochemistry,Brain Health Imaging Centre,Centre for Addiction and Mental Health &Department of Psychiatry,University of Toronto;Department of Pharmacy,the First Affiliated Hospital of Jinan University).Recent developments on PET radiotracers for TSPO and their applications in neuroimaging[J].Acta Pharmaceutica Sinica B,2021,第2期
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Yifan Chen,Xuejing Shao,Ji Cao,Hong Zhu,Bo Yang,Qiaojun He,Meidan Ying(Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University).Phosphorylation regulates cullin-based ubiquitination in tumorigenesis[J].Acta Pharmaceutica Sinica B,2021,第2期
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Kaiyue Yu,Xiuming Yu,Sisi Cao,Yixuan Wang,Yuanhao Zhai,Fengdie Yang,Xiaoyuan Yang,Yi Lu,Chuanbin Wu,Yuehong Xu(School of Pharmaceutical Sciences,Sun Yat-sen University).Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis[J].Acta Pharmaceutica Sinica B,2021,第2期
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Yunkai Yang1,Xiaohan Guo1,Bo Hu2,Peng He1,Xiaowu Jiang3,Zuohuan Wang4,Huaxing Zhu2,Lina Hu5,Minghua Yu5,Meiqing Feng1(Shanghai Engineering Research Center of Immuno Therapeutics,School of Pharmacy,Fudan University;Shanghai Novoprotein Biotechnology Co.,Ltd.;Medical School of Yichun University;Clinical Research Center,2nd Affiliated Hospital,Medical College of Zhejiang University;Department of Oncology,Shanghai Pudong Hospital,Fudan University Pudong Medicine Center).Generated SecPen_NY-ESO-1_ubiquitin-pulsed dendritic cell cancer vaccine elicits stronger and specific T cell immune responses[J].Acta Pharmaceutica Sinica B,2021,第2期
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Hao Cai1,Yufan Xiang1,Yujun Zeng1,Zhiqian Li1,Xiuli Zheng1,Qiang Luo1,Hongyan Zhu2,Qiyong Gong1,Zhongwei Gu1,Yanhui Liu1,Hu Zhang3,Kui Luo1(Huaxi MR Research Center(HMRRC),Department of Neurosurgery,and Department of Radiology,Functional and Molecular Imaging Key Laboratory of Sichuan Province,West China Hospital,Sichuan University;Laboratory of Stem Cell Biology,West China Hospital,Sichuan University;Amgen Bioprocessing Centre,Keck Graduate Institute).Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment[J].Acta Pharmaceutica Sinica B,2021,第2期
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Dominik Bakalarz1,2,Marcin Surmiak1,3,Xiaoxiao Yang4,Dagmara Wójcik1,Edyta Korbut1,Zbigniew ?liwowski1,Grzegorz Ginter1,Grzegorz Buszewicz5,Tomasz Brzozowski1,Jakub Cieszkowskia1,Urszula G?owacka1,Katarzyna Magierowska1,Zhixiang Pan4,Binghe Wang4,Marcin Magierowski1(Department of Physiology,Jagiellonian University Medical College;Department of Forensic Toxicology,Institute of Forensic Research;Department of Internal Medicine,Jagiellonian University Medical College;Department of Chemistry and Center for Diagnostics and Therapeutics,Georgia State University;Department of Forensic Medicine,Medical University of Lublin).Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage[J].Acta Pharmaceutica Sinica B,2021,第2期
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Keqi Wang1,Yongyan Chen1,Shuo Gao1,Maosi Wang1,Mengmeng Ge1,Qian Yang1,Mingkai Liao1,Lin Xu1,Junjie Chen1,2,Zhiping Zeng1,2,Haifeng Chen1,Xiao-kun Zhang1,2,Ting Lin1,Hu Zhou1,2(School of Pharmaceutical Sciences,Fujian Provincial Key Laboratory of Innovative Drug Target Research,Xiamen University;High Throughput Drug Screening Platform,Xiamen University).Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ERa to inhibit RANKL signaling[J].Acta Pharmaceutica Sinica B,2021,第2期
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Hu Zhou1,Gang He2,Yanbin Sun2,Jingguo Wang2,Haitao Wu2,Ping Jin1,Zhengbao Zha2(Shenzhen Maternity and Child Healthcare Hospital,Shandong University;School of Food and Biological Engineering,School of Instrument Science and Opto-Electronics Engineering,Hefei University of Technology).Cryptobiosis-inspired assembly of “AND” logic gate platform for potential tumor-specific drug delivery[J].Acta Pharmaceutica Sinica B,2021,第2期
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Pengzhao Shang1,Rui Gao1,Yijia Zhu1,Xiaorui Zhang1,Yang Wang1,Minji Guo1,Hui Peng2,Min Wang1,Juan Zhang1(Antibody Engineering Laboratory,School of Life Science & Technology,China Pharmaceutical University;Department of Operational Medicine,Tianjin Institute of Environmental & Operational Medicine).VEGFR2-targeted antibody fused with IFNamut regulates the tumor microenvironment of colorectal cancer and exhibits potent anti-tumor and anti-metastasis activity[J].Acta Pharmaceutica Sinica B,2021,第2期
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Xinran Cai1,Ye Feng1,2,Meishu Xu1,Chaohui Yu3,Wen Xie1,4(Center for Pharmacogenetics and Department of Pharmaceutical Sciences,University of Pittsburgh;Department of Endocrinology and Metabolic Disease,the First Affiliated Hospital,Zhejiang University School of Medicine;Department of Gastroenterology,the First Affiliated Hospital,Zhejiang University School of Medicine;Department of Pharmacology and Chemical Biology,University of Pittsburgh).Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor(CAR)[J].Acta Pharmaceutica Sinica B,2021,第2期
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Qiaozhen Wang1,Xiaolong Tang2,Ping Dai1,Chuanxi Wang1,Weiyang Zhang2,Guodong Chen1,Kui Hong3,Dan Hu1,Hao Gao1,Xinsheng Yao1(Institute of Traditional Chinese Medicine and Natural Product/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,College of Pharmacy,Jinan University;Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences;Key Laboratory of Combinatorial Biosynthesis and Drug Discovery,Ministry of Education,School of Pharmaceutical Sciences,Wuhan University).A four-protein metabolon assembled by a small peptide protein creates the pentacyclic carbonate ring of aldgamycins[J].Acta Pharmaceutica Sinica B,2021,第2期
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Xiaohua Liu1,2,3,Yu Zhang4,Yalei Li5,Juan Wang4,Huaqian Ding1,3,Wenjing Huang4,Chunyong Ding1,2,Hongchun Liu5,Wenfu Tan4,Ao Zhang1,2,6,3,7(CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica (SIMM),Chinese Academy of Sciences;School of Pharmacy,Shanghai Jiao Tong University;University of Chinese Academy of Sciences;Department of Pharmacology,School of Pharmacy,Fudan University;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica (SIMM),Chinese Academy of Sciences;School of Life Science and Technology,Shanghai Tech University;State Key Laboratory of Esophageal Cancer Prevention and Treatment,Ministry of Education of China,Zhengzhou University).Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma[J].Acta Pharmaceutica Sinica B,2021,第2期
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Editoral Office of Acta Pharmaceutica Sinica(Editoral Office of Acta Pharmaceutica Sinica).Information for Authors[J].Acta Pharmaceutica Sinica B,2021,第2期
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Xiaofei Chen1,Yunlong Wu2,Chun Chen3,Yanqiu Gu3,Chunyan Zhu2,Suping Wang2,Jiayun Chen2,Lei Zhang1,Lei Lv4,Guoqing Zhang4,Yongfang Yuan3,Yifeng Chai1,Mingshe Zhu5,Caisheng Wu2(School of Pharmacy,Naval Medical University;Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology,School of Pharmaceutical Sciences,Xiamen University;Department of Pharmacy,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University;Department of Pharmacy,Shanghai Eastern Hepatobiliary Surgery Hospital,Naval Medical University;Mass Defect Technologies).Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening[J].Acta Pharmaceutica Sinica B,2021,第1期
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Hongxia Duan1,2,Yanhong Liu1,2,Zhonggao Gao1,2,Wei Huang1,2(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Department of Pharmaceutics,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College).Recent advances in drug delivery systems for targeting cancer stem cells[J].Acta Pharmaceutica Sinica B,2021,第1期
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Yanying Zhou1,Xiaomei Fan2,Tingying Jiao1,Wenzhou Li2,Panpan Chen1,Yiming Jiang1,Jiahong Sun1,Yixin Chen1,Pan Chen3,Lihuan Guan1,Yajie Wen1,Min Huang1,Huichang Bi1(School of Pharmaceutical Sciences,Sun Yat-sen University;Shenzhen Baoan Women’s and Children’s Hospital,Jinan University;Department of Pharmacy,the First Affiliated Hospital of Sun Yat-sen University).SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation[J].Acta Pharmaceutica Sinica B,2021,第1期
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Jiezhou Ye1,Bo Zeng1,Meiyan Zhong1,Hongchun Li2,Lihui Xu3,Junxiang Shu2,Yaofeng Wang1,Fan Yang1,Chunsu Zhong1,Xunjia Ye1,Xianhui He1,Dongyun Ouyang1(Department of Immunobiology,College of Life Science and Technology,Jinan University;Wuzhongpei Memorial Hospital of Shunde;Department of Cell Biology,College of Life Science and Technology,Jinan University).Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling[J].Acta Pharmaceutica Sinica B,2021,第1期
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Xiaojie Chen1,Jiafeng Zou1,Ke Zhang1,Jingjing Zhu1,Yue Zhang1,Zhihong Zhu1,Hongyue Zheng2,Fanzhu Li1,Ji-Gang Piao1(College of Pharmaceutical Sciences,Zhejiang Chinese Medical University;Libraries of Zhejiang Chinese Medical University,Zhejiang Chinese Medical University).Photothermal/matrix metalloproteinase-2 dual-responsive gelatin nanoparticles for breast cancer treatment[J].Acta Pharmaceutica Sinica B,2021,第1期
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Hao Zengy,Lingling Wangy,Jiawei Zhang,Ting Pan,Yinghua Yu,Jingxia Lu,Ping Zhou,Hua Yang,Ping Li(State Key Laboratory of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University).Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity:Therapeutic efficacy of dihydrotanshinone-Ⅰ[J].Acta Pharmaceutica Sinica B,2021,第1期
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Zhendong Song1,Meijing Wang2,Yang Ge1,Xue-Ping Chen1,Ziyang Xu2,Yang Sun2,Xiao-Feng Xiong1(Guangdong Key Laboratory of Chiral Molecule and Drug Discovery,School of Pharmaceutical Sciences,Sun Yatsen University;State Key Laboratory of Pharmaceutical Biotechnology,Department of Biotechnology and Pharmaceutical Sciences,School of Life Sciences,Nanjing University).Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies[J].Acta Pharmaceutica Sinica B,2021,第1期
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Yilan Shen1,Wei Chen2,3,Lei Han2,Qi Bian1,Jiajun Fan2,Zhonglian Cao2,Xin Jin2,Tao Ding1,Zongshu Xian2,Zhiyong Guo1,Wei Zhang4,Dianwen Ju2,Xiaobin Mei1(Department of Nephrology,Changhai Hospital,Second Military Medical University;Department of Biological Medicines,Fudan University School of Pharmacy;Department of Ophthalmology,Stanford University School of Medicine;Department of Nephrology,Shanghai Yangpu Hospital of TCM).VEGF-B antibody and interleukin-22 fusion protein ameliorates diabetic nephropathy through inhibiting lipid accumulation and inflammatory responses[J].Acta Pharmaceutica Sinica B,2021,第1期
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Kai Yuan1,2,Xiao Wang1,2,Haojie Dong1,2,Wenjian Min1,2,Haiping Hao1,2,Peng Yang1,2(State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization,China Pharmaceutical University;Department of Medicinal Chemistry,School of Pharmacy,China Pharmaceutical University).Selective inhibition of CDK4/6:A safe and effective strategy for developing anticancer drugs[J].Acta Pharmaceutica Sinica B,2021,第1期
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Xiaopan Gao1,Bo Qin1,Pu Chen1,Kaixiang Zhu1,Pengjiao Hou1,Justyna Aleksandra Wojdyla2,Meitian Wang2,Sheng Cui1(NHC Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology,Chinese Academy of Medical Sciences and Peking Union Medical College;The Swiss Light Source (SLS) at the Paul Scherrer Institut).Crystal structure of SARS-CoV-2 papain-like protease[J].Acta Pharmaceutica Sinica B,2021,第1期
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Xiaosa Changy,Dejuan Suny,Danfeng Shiy,Guan Wang,Yanmei Chen,Kai Zhang,Huidan Tan,Jie Liu,Bo Liu,Liang Ouyang(State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Collaborative Innovation Center of Biotherapy,Sichuan University).Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly (ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy[J].Acta Pharmaceutica Sinica B,2021,第1期
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Shuang Zhou1,Jinbo Li1,Jiang Yu1,Liyuan Yang1,Xiao Kuang1,Zhenjie Wang1,Yingli Wang1,Hongzhuo Liu1,Guimei Lin2,Zhonggui He1,Dan Liu3,Yongjun Wang1(Wuya College of Innovation,Shenyang Pharmaceutical University;School of Pharmaceutical Science,Shandong University;Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education,Shenyang Pharmaceutical University).A facile and universal method to achieve liposomal remote loading of non-ionizable drugs with outstanding safety profiles and therapeutic effect[J].Acta Pharmaceutica Sinica B,2021,第1期
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Jie Cheny,Yan Wangy,Di Zhao,Lingyuan Zhang,Weimin Zhang,Jiawen Fan,Jinting Li,Qimin Zhan(Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing),Laboratory of Molecular Oncology,Peking University Cancer Hospital & Institute).Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma(ESCC)[J].Acta Pharmaceutica Sinica B,2021,第1期
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Bing Zhao1,Xinhui Zhang1,Tingting Yu1,Ying Liu1,Xiaoling Zhang1,Yongfang Yao1,Xuejian Feng1,Hongmin Liu1,Dequan Yu2,Liying Ma1,Shangshang Qin1(State Key Laboratory of Esophageal Cancer Prevention and Treament,Key Laboratory of Technology of Drug Preparation(Zhengzhou University),Ministry of Education of China,Key Laboratory of Henan Province for Drug Quality and Evaluation,Institute of Pharmaceutical Research and School of Pharmaceutical Sciences,Zhengzhou University;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College).Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1(NDM-1) inhibitors against NDM-1 producing clinical isolates[J].Acta Pharmaceutica Sinica B,2021,第1期
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Shun Zhang1,2,3,Yan Zhao2,4,5,Shuyuan Wang2,3,Min Li2,3,Yue Xu2,3,Jianhua Ran6,Xiaoqiang Geng2,Jinzhao He2,3,Jia Meng2,3,Guangying Shao2,3,Hong Zhou2,3,Zemei Ge2,4,Guangping Chen7,Runtao Li2,4,Baoxue Yang1,2,3(Department of Pharmacology,School of Basic Medical Sciences,Peking University;State Key Laboratory of Natural and Biomimetic Drugs,Peking University;Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education;School of Pharmaceutical Sciences,Peking University;College of Pharmacy,Inner Mongolia Medical University;Department of Anatomy and Neuroscience Center,Chongqing Medical University;Department of Physiology,Emory University School of Medicine).Discovery of novel diarylamides as orally active diuretics targeting urea transporters[J].Acta Pharmaceutica Sinica B,2021,第1期
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