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Tao Su1,Suchao Huang1,Yanmin Zhang1,Yajuan Guo1,Shuwei Zhang1,Jiaji Guan1,Mingjing Meng1,Linxin Liu1,Caiyan Wang1,Dihua Yu2,Hiu-Yee Kwan3,Zhiying Huang1,Qiuju Huang1,Elaine Lai-Han Leung4,Ming Hue5,Ying Wang1,Zhongqiu Liu1,4,Linlin Lu1,4(Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China,Guangzhou University of Chinese Medicine;Department of Molecular and Cellular Oncology,the University of Texas MD Anderson Cancer Center;School of Chinese Medicine,Hong Kong Baptist University;State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health,Macau University of Science and Technology;Department of Pharmacological and Pharmaceutical Sciences,University of Houston).miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis[J].Acta Pharmaceutica Sinica B,2022,第2期
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Min Liao1,Ruiqing Chen1,Yang Yang1,Hanqing He1,Liqian Xu1,Yuxuan Jiang1,Zhenxing Guo2,Wei He1,Hong Jiang3,Jianwei Wang1(School of Pharmaceutical Sciences,Tsinghua University;Department of Hematology/Oncology,First Hospital of Tsinghua University;Kidney Disease Center,the First Affiliated Hospital,College of Medicine,Zhejiang University).Aging-elevated inflammation promotes DNMT3A R878H-driven clonal hematopoiesis[J].Acta Pharmaceutica Sinica B,2022,第2期
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Steven N.Austad1,Scott Ballinger2,Thomas W.Buford3,Christy S.Carter3,Daniel L.Smith Jr4,Victor Darley-Usmar2,Jianhua Zhang2(Department of Biology,University of Alabama at Birmingham;Department of Pathology,University of Alabama at Birmingham;Department of Medicine,University of Alabama at Birmingham;Department of Nutrition Sciences,University of Alabama at Birmingham).Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer’s disease[J].Acta Pharmaceutica Sinica B,2022,第2期
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Qiufen Zhang1,2,Yingyi Chen1,Duan Ni1,Zhimin Huang1,Jiacheng Wei1,Li Feng2,Jun-Cheng Su1,Yingqing Wei1,Shaobo Ning1,Xiuyan Yang1,Mingzhu Zhao1,Yuran Qiu2,Kun Song2,Zhengtian Yu3,Jianrong Xu4,Xinyi Li2,Houwen Lin1,Shaoyong Lu1,Jian Zhang1,2,5(State Key Laboratory of Oncogenes and Related Genes,Department of Pharmacy,Renji Hospital,Shanghai Jiao Tong University School of Medicine;Medicinal Chemistry and Bioinformatics Center,Shanghai Jiao Tong University School of Medicine;Nutshell Therapeutics;Academy of Integrative Medicine,Shanghai University of Traditional Chinese Medicine;School of Pharmaceutical Sciences,Zhengzhou University).Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells[J].Acta Pharmaceutica Sinica B,2022,第2期
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Leilei Fu1,Wenke Jin1,Jiahui Zhang2,3,Lingjuan Zhu2,3,Jia Lu4,Yongqi Zhen1,Lan Zhang1,Liang Ouyang2,Bo Liu2,Haiyang Yu4(Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs,School of Life Science and Engineering,Southwest Jiaotong University;State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University;College of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University;State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine).Repurposing non-oncology small-molecule drugs to improve cancer therapy:Current situation and future directions[J].Acta Pharmaceutica Sinica B,2022,第2期
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Zi Ye1,Ke Wang1,Lianguo Chen1,Xiaofeng Jin1,Hao Chen1,Guanghui Tang2,Shao Q.Yao2,Zhiqiang Feng1,Chong-Jing Zhang1(State Key Laboratory of Bioactive Substances and Functions of Natural Medicines and Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation,Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences;Department of Chemistry,National University of Singapore).A targeted covalent inhibitor of p97 with proteome-wide selectivity[J].Acta Pharmaceutica Sinica B,2022,第2期
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Lijun Shao1,2,3,Yan Chen4,Shikai Zhang5,Zhihui Zhang5,Yongbing Cao5,Dehua Yang1,2,3,Ming-Wei Wang1,2,3,4,6(The National Center for Drug Screening and CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences(CAS);School of Life Science and Technology,Shanghai Tech University;University of Chinese Academy of Sciences;School of Pharmacy,Fudan University;Shanghai TCM-Integrated Hospital,Shanghai University of Traditional Chinese Medicine;Department of Pharmacology,School of Basic Medical Sciences,Fudan University).Modulating effects of RAMPs on signaling profiles of the glucagon receptor family[J].Acta Pharmaceutica Sinica B,2022,第2期
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Ming Ji1,2,Dongjie Wang3,Songwen Lin1,Chunyang Wang3,Ling Li2,Zhihui Zhang3,Jing Jin1,2,Deyu Wu1,Yi Dong1,Heng Xu1,Duo Lu1,Xiaoguang Chen1,3(State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College).A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models[J].Acta Pharmaceutica Sinica B,2022,第2期
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Benjamin R.Troutwine1,2,Laylan Hamid2,Colton R.Lysaker2,3,Taylor A.Strope2,3,Heather M.Wilkins1,2,3(Department of Neurology University of Kansas Medical Center;University of Kansas Alzheimer's Disease Center;Department of Biochemistry and Molecular Biology,University of Kansas Medical Center).Apolipoprotein E and Alzheimer’s disease[J].Acta Pharmaceutica Sinica B,2022,第2期
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Zhifan Mao1,Wenwen Liu1,Yunyuan Huang1,Tianyue Sun1,Keting Bao1,Jiali Feng1,Alexey Moskalev2,Zelan Hu1,Jian Li1,3,4(State Key Laboratory of Bioreactor Engineering,Frontiers Science Center for Materiobiology and Dynamic Chemistry,Shanghai Key Laboratory of New Drug Design,East China University of Science and Technology;Laboratory of Geroprotective and Radioprotective Technologies,Institute of Biology,Komi Science Centre,Ural Branch,Russian Academy of Sciences;Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yunnan,College of Pharmacy,Dali University;Clinical Medicine Scientific and Technical Innovation Center,Shanghai Tenth People's Hospital,Tongji University School of Medicine).Anti-aging effects of chlorpropamide depend on mitochondrial complex-Ⅱ and the production of mitochondrial reactive oxygen species[J].Acta Pharmaceutica Sinica B,2022,第2期
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Carlos Bendicho-Lavilla1,2,Iria Seoane-Via?o1,2,Francisco J.Otero-Espinar1,2,Asteria Luzardo-álvarez2,3(Department of Pharmacology,Pharmacy and Pharmaceutical Technology,Faculty of Pharmacy,University of Santiago de Compostela (USC);Paraquasil Group,Health Research Institute of Santiago de Compostela (IDIS);Department of Pharmacology,Pharmacy and Pharmaceutical Technology,School of Sciences,Campus de Lugo,University of Santiago de Compostela).Fighting type 2 diabetes:Formulation strategies for peptide-based therapeutics[J].Acta Pharmaceutica Sinica B,2022,第2期
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Jing Shi1,2,Rui Ju1,Hongting Gao1,Yuqing Huang1,Lei Guo1,Dechang Zhang1(Department of Pharmacology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and School of Basic Medicine,Peking Union Medical College;Department of Pharmacy,Peking University Third Hospital).Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability[J].Acta Pharmaceutica Sinica B,2022,第2期
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Xinping Kuai1,Yuefei Zhu2,Zheng Yuan3,Shengyu Wang4,Lin Lin1,Xiaodan Ye5,Yiping Lu1,Yu Luo6,Zhiqing Pang2,Daoying Geng1,Bo Yin1(Department of Radiology,Huashan Hospital,Fudan University;School of Pharmacy,Fudan University,Key Laboratory of Smart Drug Delivery,Ministry of Education;Department of Radiology,Shanghai First Maternity and Infant Hospital,Tongji University School of Medicine;Department of Radiology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine;Department of Radiology,Shanghai Chest Hospital,Shanghai Jiao Tong University;State Key Laboratory of High Performance Ceramics and Superfine Microstructure,School of Chemical Science and Engineering).Perfluorooctyl bromide nanoemulsions holding MnO2 nanoparticles with dual-modality imaging and glutathione depletion enhanced HIFU-eliciting tumor immunogenic cell death[J].Acta Pharmaceutica Sinica B,2022,第2期
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Mallory Little1,Moumita Dutta1,Hao Li2,Adam Matson3,Xiaojian Shi4,Gabby Mascarinas1,Bruk Molla1,Kris Weigel1,Haiwei Gu4,Sridhar Mani2,Julia Yue Cui1(Department of Environmental and Occupational Health Sciences,University of Washington;Department of Medicine,Molecular Pharmacology and Genetics,Albert Einstein College of Medicine;University of Connecticut;Arizona Metabolomics Laboratory,College of Health Solutions,Arizona State University).Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice[J].Acta Pharmaceutica Sinica B,2022,第2期
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Juan Liu1,Yuxin Zhuang1,Jianlin Wu1,Qiang Wu1,Meixian Liu1,Yue Zhao1,Zhongqiu Liu2,Caiyan Wang2,Linlin Lu2,Yingjiao Meng1,Kawai Lei1,Xiaojuan Li3,Qibiao Wu1,Elaine Lai-Han Leung1,Zhengyang Guo1,Liang Liu1,Ting Li1,4,5(State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health,Macau University of Science and Technology;International Institute for Translational Chinese Medicine,Guangzhou University of Chinese Medicine;Guangdong Provincial Key Laboratory of New Drug Screening/Laboratory of Anti-inflammatory and Immunomodulatory Pharmacology,School of Pharmaceutical Sciences,Southern Medical University;Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease,Macau University of Science and Technology;Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China,Macau University of Science and Technology).IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα[J].Acta Pharmaceutica Sinica B,2022,第2期
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Xiaobei Cheng1,Pei Yu1,Xiang Zhou2,Jiale Zhu1,Yubao Han1,Chao Zhang1,Lingyi Kong1(State Key Laboratory of Natural Medicines,Jiangsu Key Laboratory of Bioactive Natural Product Research,School of Traditional Chinese Pharmacy,China Pharmaceutical University;Department of Science,China Pharmaceutical University).Enhanced tumor homing of pathogen-mimicking liposomes driven by R848 stimulation:A new platform for synergistic oncology therapy[J].Acta Pharmaceutica Sinica B,2022,第2期
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Mao Zhifan Liu Wenwen Huang Yunyuan Sun Tianyue Bao Keting Feng Jiali Moskalev Alexey Hu Zelan Li Jian(East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering;Frontiers Science Center for Materiobiology and Dynamic Chemistry;Shanghai Key Laboratory of New Drug Design, Shanghai, 200237;Laboratory of Geroprotective and Radioprotective Technologies,Institute of Biology,Komi Science Centre,Ural Branch,Russian Academy of Sciences, Russia, Syktyvkar, 167982;College of Pharmacy,Dali University, Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yun, Dali, 671000;Clinical Medicine Scientific and Technical Innovation Center,Shanghai Tenth People's Hospital,Tongji University School of Medicine, Shanghai, 200092).Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species[J].Acta Pharmaceutica Sinica B,2022,第2期
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Xiaoxi Lv1,Chang Liu1,2,Shanshan Liu1,Yunxuan Li1,Wanyu Wang1,Ke Li3,Fang Hua1,Bing Cui1,Xiaowei Zhang1,Jiaojiao Yu1,Jinmei Yu1,Zhuo Wei Hu1(Immunology and Cancer Pharmacology Group,State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College;Drug Clinical Trial Institution,Children's Hospital,Capital Institute of Pediatrics;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College).The cell cycle inhibitor P21 promotes the development of pulmonary fibrosis by suppressing lung alveolar regeneration[J].Acta Pharmaceutica Sinica B,2022,第2期
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Mengchi Sun1,Hailun Jiang2,Tian Liu1,Xiao Tan1,Qikun Jiang1,Bingjun Sun2,Yulong Zheng3,Gang Wang4,Yang Wang4,Maosheng Cheng2,Zhonggui He1,Jin Sun1(Wuya College of Innovation,Shenyang Pharmaceutical University;Key Laboratory of Structure-Based Drug Design and Discovery,Shenyang Pharmaceutical University,Ministry of Education;School of Materials Science and Engineering,Ocean University of China;College of Pharmacy,Guangxi University of Chinese Medicine).Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metastatic breast tumors[J].Acta Pharmaceutica Sinica B,2022,第2期
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Huiling Chen1,Kaiqiang Hu1,Yaru Liang1,Yuqi Gao1,Chenye Zeng1,Kang Xu1,Xiaojin Shi1,Liyuan Li1,Yuemiao Yin1,Yi Qiao2,Ying Qiu3,Qingfei Liu1,Zhao Wang1(School of Pharmaceutical Sciences,Tsinghua University;Urology Department,Peking Union Medical College Hospital;School of Medicine,Tsinghua University).Ample dietary fat reduced the risk of primary vesical calculi by inducing macrophages to engulf budding crystals in mice[J].Acta Pharmaceutica Sinica B,2022,第2期
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Editoral Office of Acta Pharmaceutica Sinica(Editoral Office of Acta Pharmaceutica Sinica).Information for Authors[J].Acta Pharmaceutica Sinica B,2022,第2期
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Jincheng Wang1,Kaili Hu1,2,Xuanyan Cai1,Bo Yang2,Qiaojun He1,2,Jiajia Wang1,Qinjie Weng1,2(Center for Drug Safety Evaluation and Research,College of Pharmaceutical Sciences,Zhejiang University;Hangzhou Institute of Innovative Medicine,College of Pharmaceutical Sciences,Zhejiang University).Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis[J].Acta Pharmaceutica Sinica B,2022,第1期
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Patrick Kwabena Oduro1,Xianxian Zheng1,Jinna Wei1,Yanze Yang1,Yuefei Wang1,2,Han Zhang1,2,Erwei Liu1,2,Xiumei Gao1,2,Mei Du3,Qilong Wang1,2(Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine;State Key Laboratory of Component-Based Chinese Medicine,Ministry of Education;Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology,School of Basic Medical Sciences,Tianjin Medical University).The cGAS-STING signaling in cardiovascular and metabolic diseases:Future novel target option for pharmacotherapy[J].Acta Pharmaceutica Sinica B,2022,第1期
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Katherine Byrnes,Sophia Blessinger,Niani Tiaye Bailey,Russell Scaife,Gang Liu,Bilon Khambu(Department of Pathology and Laboratory Medicine,Tulane University School of Medicine).Therapeutic regulation of autophagy in hepatic metabolism[J].Acta Pharmaceutica Sinica B,2022,第1期
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Jinjing Wei1,Yongting Zhao2,Haihai Liang3,Weijie Du3,Lihong Wang1(Department of Endocrinology,the First Affiliated Hospital of Jinan University;Department of Endocrinology,the Second Affiliated Hospital of Harbin Medical University;Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China,Key Laboratory of Cardiovascular Research,Ministry of Education),College of Pharmacy,Harbin Medical University).Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy[J].Acta Pharmaceutica Sinica B,2022,第1期
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Shuwen Fu1,Guanting Li2,Wenli Zang3,Xinyu Zhou4,Kexin Shi5,Yinglei Zhai5(School of Pharmacy,Shenyang Pharmaceutical University;Department of Pharmaceutics,Wuya College of Innovation,Shenyang Pharmaceutical University;Department of Periodontology,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Disease;Bio-system Pharmacology,Graduate School of Medicine,Faculty of Medicine,Osaka University;Department of Biomedical Engineering,School of Medical Device,Shenyang Pharmaceutical University).Pure drug nano-assemblies:A facile carrier-free nanoplatform for efficient cancer therapy[J].Acta Pharmaceutica Sinica B,2022,第1期
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Dandan Sun1,Yifang Zou1,Liu Song1,Shulan Han1,Hao Yang1,Di Chu1,Yun Dai2,Jie Ma1,Caitriona M.O'Driscoll3,Zhuo Yu4,Jianfeng Guo1(School of Pharmaceutical Sciences,Jilin University;Laboratory of Cancer Precision Medicine,The First Hospital of Jilin University;Pharmacodelivery Group,School of Pharmacy,University College Cork;Department of Hepatopathy,Shuguang Hospital,Affiliated to Shanghai University of Traditional Chinese Medicine).A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer[J].Acta Pharmaceutica Sinica B,2022,第1期
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Qianqian Li1,Zhaoqing Shi1,Fan Zhang1,Weiwei Zeng1,Dunwan Zhu2,Lin Mei2(School of Pharmaceutical Sciences (Shenzhen),Sun Yat-sen University;Tianjin Key Laboratory of Biomedical Materials,Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences & Peking Union Medical College).Symphony of nanomaterials and immunotherapy based on the cancer-immunity cycle[J].Acta Pharmaceutica Sinica B,2022,第1期
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