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Sang Hoon Lee,Jae Geun Song,Hyo-Kyung Han(College of Pharmacy,Dongguk University-Seoul).Site-selective oral delivery of therapeutic antibodies to the inflamed colon via a folic acid-grafted organic/inorganic hybrid nanocomposite system[J].Acta Pharmaceutica Sinica B,2022,第11期
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Jie Tu,Na Liu,Yahui Huang,Wanzhen Yang,Chunquan Sheng(School of Pharmacy,Second Military Medical University).Small molecules for combating multidrug-resistant superbug Candida auris infections[J].Acta Pharmaceutica Sinica B,2022,第11期
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Liping Liao1,2,Wenzhen Dang3,1,Tingting Lin1,2,Jinghua Yu1,Tonghai Liu1,2,Wen Li1,Senhao Xiao1,2,Lei Feng1,2,Jing Huang1,2,Rong Fu1,Jiacheng Li1,2,Liping Liu1,2,Mingchen Wang1,2,Hongru Tao1,Hualiang Jiang1,2,Kaixian Chen1,2,Xingxing Diao1,Bing Zhou1,4,Xiaoyan Shen3,Cheng Luo3,1,2,4,5(State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Department of Pharmacology & the Key Laboratory of Smart Drug Delivery,Ministry of Education,School of Pharmacy,Fudan University;School of Pharmaceutical Science and Technology,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences;School of Pharmaceutical Sciences,Zhejiang Chinese Medical University).A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6[J].Acta Pharmaceutica Sinica B,2022,第11期
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Hongxi Hu,Cuicui Xie,Huiyan Xu,Liyun Zhou(Pharmcube(Beijing) Co.,Ltd.).Drug discovery in China:A snapshot of recent progress[J].Acta Pharmaceutica Sinica B,2022,第11期
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Qian Hu1,Jiaqi Yao1,Xiajia Wu1,Juan Li1,Guixiang Li1,Wenfu Tang1,Jingping Liu2,Meihua Wan1(Department of Integrated Traditional Chinese and Western Medicine,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University;NHC Key Laboratory of Transplant Engineering and Immunology,Frontiers Science Center for Disease-Related Molecular Network,West China Hospital,Sichuan University).Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation[J].Acta Pharmaceutica Sinica B,2022,第10期
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Ling Zou1,2,Minru Liao2,Yongqi Zhen2,Shiou Zhu2,Xiya Chen1,Jin Zhang1,2,Yue Hao1,Bo Liu2(School of Pharmaceutical Sciences,Health Science Center,Shenzhen University;State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University).Autophagy and beyond:Unraveling the complexity of UNC-51-like kinase 1(ULK1) from biological functions to therapeutic implications[J].Acta Pharmaceutica Sinica B,2022,第10期
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Xin Cao1,Xiaojing Du1,Heng Jiao1,Quanlin An1,Ruoxue Chen1,Pengfei Fang2,Jing Wang2,Biao Yu2(Zhongshan Hospital Institute of Clinical Science,Fudan University Shanghai Medical College;State Key Laboratory of Bio-organic and Natural Products Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences).Carbohydrate-based drugs launched during 2000-2021[J].Acta Pharmaceutica Sinica B,2022,第10期
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Shan Liu1,2,Xue Wu3,Sutapa Chandra2,Christopher Lyon2,Bo Ning2,Li jiang1,Jia Fan2,Tony Y.Hu2(Sichuan Provincial Key Laboratory for Human Disease Gene Study,Department of Medical Genetics,Department of Laboratory Medicine,Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital;Department of Biochemistry and Molecular Biology,Center for Cellular and Molecular Diagnosis,School of Medicine,Tulane University;The M.O.E.Key Laboratory of Laboratory Medical Diagnostics,the College of Laboratory Medicine,Chongqing Medical University;Sichuan Provincial Key Laboratory for Human Disease Gene Study,Department of Medical Genetics,Department of Laboratory Medicine,Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital).Extracellular vesicles:Emerging tools as therapeutic agent carriers[J].Acta Pharmaceutica Sinica B,2022,第10期
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Xiaoqing Zhou,Shaoyang Zhao,Tingting Liu,Lu Yao,Meimei Zhao,Xiaoming Ye,Xiaowen Zhang,Qiang Guo,Pengfei Tu,Kewu Zeng(State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University).Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase[J].Acta Pharmaceutica Sinica B,2022,第10期
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Xueping Lei1,2,Zhan Li1,Yihang Zhong1,Songpei Li1,Jiacong Chen1,Yuanyu Ke1,Sha Lv1,Lijuan Huang1,Qianrong Pan1,Lixin Zhao1,Xiangyu Yang1,Zisheng Chen2,Qiudi Deng4,Xiyong Yu1(Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology,the NMPA and State Key Laboratory of Respiratory Disease,School of Pharmaceutical Sciences and the Fifth Affiliated Hospital,Guangzhou Medical University;Department of Respiratory and Critical Care Medicine,the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People's Hospital;Department of Respiratory and Critical Care Medicine,the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People’s Hospital;GMU-GIBH Joint School of Life Sciences,Guangzhou Medical University).Gli1 promotes epithelial-mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability[J].Acta Pharmaceutica Sinica B,2022,第10期
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Leyang Wu1,2,Lin Li1,Shufeng Li3,Lina Liu1,Wenjie Xin1,Chenyang Li1,Xingpeng Yin1,Xuebo Xu1,Feifei Bao1,Zichun Hua1,2,4(The State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University;Changzhou High-Tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories Inc.;Key Laboratory of Developmental Genes and Human Disease in Ministry of Education,Department of Biochemistry and Molecular Biology,Medical School of Southeast University;School of Biopharmacy,China Pharmaceutical University).Macrophage-mediated tumor-targeted delivery of engineered Salmonella typhimurium VNP20009 in anti-PD1 therapy against melanoma[J].Acta Pharmaceutica Sinica B,2022,第10期
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Jinlian Wei1,Xin Chen1,Yongyun Li,Ruoxi Li1,Keting Bao1,Liang Liao1,Yuqing Xie1,Tiannuo Yang1,Jin Zhu1,Fei Mao1,Shuaishuai Ni3,Renbing Jia,Xiaofang Xu,Jian Li1,4,5,6(State Key Laboratory of Bioreactor Engineering,Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,Frontiers Science Center for Materiobiology and Dynamic Chemistry,Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology;Department of Ophthalmology,Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine;Cancer Institute,Longhua Hospital,Shanghai University of Traditional Chinese Medicine;Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yunnan,College of Pharmacy,Dali University;Clinical Medicine Scientific and Technical Innovation Center,Shanghai Tenth People's Hospital,Tongji University School of Medicine;Key Laboratory of Tropical Biological Resources of Ministry of Education,College of Pharmacy,Hainan University).Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway[J].Acta Pharmaceutica Sinica B,2022,第10期
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Ping Bai1,Prasenjit Mondal2,Frederick A.Bagdasarian1,Nisha Rani1,Yan Liu1,Ashley Gomm2,Darcy R.Tocci1,Se Hoon Choi2,Hsiao-Ying Wey1,Rudolph E.Tanzi2,Can Zhang2,Changning Wang1(Athinoula A.Martinos Center for Biomedical Imaging,Department of Radiology,Massachusetts General Hospital,Harvard Medical School;Genetics and Aging Research Unit,McCance Center for Brain Health,MassGeneral Institute for Neurodegenerative Disease,Department of Neurology,Massachusetts General Hospital,Harvard Medical School).Development of a potential PET probe for HDAC6 imaging in Alzheimer’s disease[J].Acta Pharmaceutica Sinica B,2022,第10期
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Aneesh V.Karkhanis1,2,Gopalakrishnan Venkatesan1,3,Ryuichi Kambayashi4,Jacqueline Wen Hui Leow1,Marcus Qingrui Han1,Hiroko Izumi-Nakaseko4,Ai Goto4,Jeremy Kah Sheng Pang5,Boon Seng Soh5,6,Pipin Kojodjojo7,Atsushi Sugiyama4,Eric Chun Yong Chan1(Department of Pharmacy,Faculty of Science,National University of Singapore;A*STAR Skin Research Labs,Agency for Science,Technology and Research;Antimicrobial Resistance Interdisciplinary Research Group,Singapore-MIT Alliance for Research and Technology;Department of Pharmacology,Faculty of Medicine,Toho University;Institute of Molecular and Cell Biology,Agency for Science,Technology and Research;Department of Biological Sciences,Faculty of Science,National University of Singapore;Department of Medicine,Yong Loo Lin School of Medicine,National University of Singapore).Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts[J].Acta Pharmaceutica Sinica B,2022,第10期
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Bo Qin1,Gregory B.Craven2,Pengjiao Hou1,Julian Chesti3,Xinran Lu3,Emma S.Child2,Rhodri M.L.Morgan2,Wenchao Niu4,Lina Zhao4,Alan Armstrong3,David J.Mann2,Sheng Cui1(NHC Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Life Sciences,Imperial College London,South Kensington Campus;Department of Chemistry,Imperial College London,Molecular Sciences Research Hub,White City Campus;CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Institute of High Energy Physics,University of Chinese Academy of Sciences).Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease[J].Acta Pharmaceutica Sinica B,2022,第10期
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Xuan Yang1,Yalong Wang1,Junke Zhao1,Hehui Rong1,Yujun Chen2,Mengting Xiong1,Xiaoxing Ye1,Shihui Yu1,3,Haiyan Hu1,3(School of Pharmaceutical Sciences,Sun Yat-sen University;The First Affiliated Hospital of Guangxi Medical University;Guangdong Provincial Key Laboratory of Chiral Molecules and Drug Discovery,Sun Yat-sen University).Coordinated regulation of BACH1 and mitochondrial metabolism through tumor-targeted self-assembled nanoparticles for effective triple negative breast cancer combination therapy[J].Acta Pharmaceutica Sinica B,2022,第10期
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Xianzi Zheng,Zhezheng Fang,Weizi Huang,Jianping Qi,Xiaochun Dong,Weili Zhao,Wei Wu,Yi Lu(Key Laboratory of Smart Drug Delivery of MOE,School of Pharmacy,Fudan University).Ionic co-aggregates (ICAs) based oral drug delivery:Solubilization and permeability improvement[J].Acta Pharmaceutica Sinica B,2022,第10期
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Yamin Liu1,2,Qiyue Wang1,Fangyuan Li3,4,Daishun Ling1,3,4(Frontiers Science Center for Transformative Molecules,School of Chemistry and Chemical Engineering,National Center for Translational Medicine,Shanghai Jiao Tong University;Department of Chemistry,Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials,Fudan University;Institute of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University;Hangzhou Institute of Innovative Medicine,Zhejiang University).Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy[J].Acta Pharmaceutica Sinica B,2022,第10期
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Wei Jinlian Chen Xin Li Yongyun Li Ruoxi Bao Keting Liao Liang Xie Yuqing Yang Tiannuo Zhu Jin Mao Fei Ni Shuaishuai Jia Renbing Xu Xiaofang Li Jian(School of Pharmacy, East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering;Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism;Frontiers Science Center for Materiobiology and Dynamic Chemistry;Shanghai Key Laboratory of New Drug Design, Shanghai, 200237;Department of Ophthalmology, Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025;Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032;College of Pharmacy, Dali University, Yunnan Key Labo, Dali, 671000;Shanghai Tenth Peoples Hospital, Tongji University School of Medicine, Shanghai, 200092;College of Pharmacy, Hainan University, Haikou, 570228).Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78eFOXM1eKIF20A pathway[J].Acta Pharmaceutica Sinica B,2022,第10期
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Zhicheng Xie1,2,Lin Li1,2,Yihao Guo3,Mi Zhang1,Taiwen Chen1,2,Yongpeng Li3,Xin Li1,2,Xi Zhu1,2,Yu Zhang1,2,Liguang Lou1,2,3,Youhong Hu1,2,3,4(State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;University of Chinese Academy of Sciences;School of Chinese Materia Medica,Nanjing University of Chinese Medicine;School of Pharmaceutical Science and Technology,Hangzhou Institute for Advanced Study,UCAS).Discovery of novel heteroaryl alkynes for highly potent KITD816V cells inhibition to treat gastrointestinal stromal tumors[J].Acta Pharmaceutica Sinica B,2022,第10期
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Jie Tong2,Dongjie Li2,3,Hongbo Meng,Diyang Sun5,Xiuting Lan2,Min Ni2,Jiawei Ma2,Feiyan Zeng2,6,Sijia Sun2,Jiangtao Fu5,Guoqiang Li5,7,Qingxin Ji2,Guoyan Zhang2,Qirui Shen8,Yuanyuan Wang2,Jiahui Zhu2,Yi Zhao2,Xujie Wang2,Yi Liu2,Shenxi Ouyang2,Chunquan Sheng9,Fuming Shen2,Pei Wang5(Department of Pharmacy,Shanghai Tenth People’s Hospital,Tongji University School of Medicine;Department of Pharmacy,Shanghai Tenth People's Hospital,Tongji University School of Medicine;Institute of Nuclear Medicine,Tongji University School of Medicine;Department of General Surgery,Shanghai Tenth People’s Hospital,Tongji University School of Medicine;Department of Pharmacology,School of Pharmacy,Naval Medical University/Second Military Medical University;Department of Pharmacy,Shanghai Fourth People's Hospital,Tongji University School of Medicine;Shanghai Key Laboratory of Regulatory Biology,Institute of Biomedical Sciences and School of Life Sciences,East China Normal University;Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University;Department of Medicinal Chemistry,School of Pharmacy,Naval Medical University/Second Military Medical University).Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease[J].Acta Pharmaceutica Sinica B,2022,第9期
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Feixia Wang1,Zhanghao Li1,Li Chen1,Ting Yang1,Baoyu Liang1,Zili Zhang1,Jiangjuan Shao1,Xuefen Xu1,Guoping Yin2,Shijun Wang3,Hai Ding4,Feng Zhang1,Shizhong Zheng1(Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,School of Pharmacy,Nanjing University of Chinese Medicine;Department of Anesthesiology,Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine;Department of General Surgery,Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine).Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis[J].Acta Pharmaceutica Sinica B,2022,第9期
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Longshan Ji1,Qian Li1,Yong He2,Xin Zhang1,Zhenhua Zhou3,Yating Gao1,Miao Fang1,Zhuo Yu3,Robim M.Rodrigues4,Yueqiu Gao1,Man Li1(Laboratory of Cellular Immunity,Institute of Clinical Immunology,Shanghai Key Laboratory of Traditional Chinese Medicine,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine),Ministry of Education;Shanghai Institute of Materia Medica,Chinese Academy of Sciences;Department of Hepatopathy,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Department of in Vitro Toxicology and Dermato-Cosmetology,Faculty of Medicine and Pharmacy,Vrije Universiteit Brussel).Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD:A promising drug Potentilla discolor Bunge[J].Acta Pharmaceutica Sinica B,2022,第9期
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Xuan Wang,Peng Hua,Chengwei He,Meiwan Chen(State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau).Non-apoptotic cell death-based cancer therapy:Molecular mechanism,pharmacological modulators,and nanomedicine[J].Acta Pharmaceutica Sinica B,2022,第9期
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Hongyu Wu1,Hong Yao1,Chen He1,Yilin Jia1,Zheying Zhu2,Shengtao Xu1,Dahong Li3,Jinyi Xu1(State Key Laboratory of Natural Medicines,Department of Medicinal Chemistry,China Pharmaceutical University;Division of Molecular Therapeutics & Formulation,School of Pharmacy,the University of Nottingham;Key Laboratory of Structure-Based Drug Design & Discovery,Ministry of Education,School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University).Molecular glues modulate protein functions by inducing protein aggregation:A promising therapeutic strategy of small molecules for disease treatment[J].Acta Pharmaceutica Sinica B,2022,第9期
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Rui Cui1,2,Luo Wang1,Dongyun Zhang1,Kun Zhang3,4,Jianping Dou1,Linan Dong1,Yixuan Zhang1,Jiapeng Wu1,Longfei Tan5,Jie Yu1,Ping Liang1(Department of Interventional Ultrasound,PLA General Hospital;Department of Medical Ultrasonics,the Sixth Affiliated Hospital,Sun Yat-sen University;Laboratory of Controllable Preparation and App Department of Medical Ultrasound,Shanghai Tenth People's Hospital,Tongji University School of Medicine;Ultrasound Research and Education Institute,Tongji University School of Medicine;Laboratory of Controllable Preparation and Application of Nanomaterials,Key Laboratory of Cryogenics,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences).Combination therapy using microwave ablation and D-mannose-chelated iron oxide nanoparticles inhibits hepatocellular carcinoma progression[J].Acta Pharmaceutica Sinica B,2022,第9期
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