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Tong Gao,Xiao Sang,Xinyan Huang,Panpan Gu,Jie Liu,Yongjun Liu,Na Zhang(Department of Pharmaceutics,Key Laboratory of Chemical Biology(Ministry of Education),NMPA Key Laboratory for Technology Research and Evaluation of Drug Products,School of Pharmaceutical Sciences,Cheeloo College of Medicine,Shandong University).Macrophage-camouflaged epigenetic nanoinducers enhance chemoimmunotherapy in triple negative breast cancer[J].Acta Pharmaceutica Sinica B,2023,第10期
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Yuechao Dong,Yangshan Chen,Guixing Ma,Huiling Cao(Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Key University Laboratory of Metabolism and Health of Guangdong).The role of E3 ubiquitin ligases in bone homeostasis and related diseases[J].Acta Pharmaceutica Sinica B,2023,第10期
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Cancan Zheng1,Xiaomei Yu1,Taoyang Xu1,Zhichao Liu2,Zhili Jiang3,Jiaojiao Xu1,Jing Yang1,Guogeng Zhang1,Yan He1,Han Yang4,Xingyuan Shi3,Zhigang Li2,Jinbao Liu5,Wen Wen Xu5(Key Laboratory of Biological Targeting Diagnosis,Therapy and Rehabilitation of Guangdong Higher Education Institutes,the Fifth Affiliated Hospital of Guangzhou Medical University;Department of Thoracic Surgery,Shanghai Chest Hospital,School of Medicine,Shanghai Jiao Tong University;Department of Radiation Oncology,the Fifth Affiliated Hospital of Guangzhou Medical University;Department of Thoracic Surgery,Sun Yat-sen University Cancer Center;Guangdong Provincial Key Laboratory of Protein Modification and Degradation,State Key Laboratory of Respiratory Disease,and School of Basic Medical Sciences,Guangzhou Medical University).KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer[J].Acta Pharmaceutica Sinica B,2023,第10期
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Shuai Shao,Chengjuan Chen,Gaona Shi,Yu Zhou,Yazi Wei,Lei Wu,Lan Sun,Tiantai Zhang(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College).JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes[J].Acta Pharmaceutica Sinica B,2023,第10期
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Yang Liu1,2,Xiaowei Zhang1,2,Ping Zhang1,2,Tingting He1,2,Weitao Zhang1,2,Dingyuan Ma,Ping Li1,Jun Chen1,2(State Key Laboratory of Natural Medicines,China Pharmaceutical University;Department of Pharmacognosy,School of Traditional Chinese Pharmacy,China Pharmaceutical University;Department of Prenatal Diagnosis,Nanjing Maternity and Child Health Care Hospital,Women’s Hospital of Nanjing Medical University).A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer[J].Acta Pharmaceutica Sinica B,2023,第10期
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Li-Long Pan1,Zheng-Nan Ren2,3,Jun Yang4,Bin-Bin Li2,3,Yi-Wen Huang2,3,Dong-Xiao Song2,3,Xuan Li2,3,Jia-Jia Xu5,Madhav Bhatia6,Duo-Wu Zou7,Chun-Hua Zhou7,Jia Sun2,3(Wuxi Medical School,Jiangnan University;School of Food Science and Technology,Jiangnan University;State Key Laboratory of Food Science and Resources,Jiangnan University;Department of General Surgery,Affiliated Hospital of Jiangnan University;Department of General Medicine,Beicai Community Health Service Center of Pudong New District;Department of Pathology,University of Otago;Department of Gastroenterology,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine).Gut microbiota controls the development of chronic pancreatitis:A critical role of short-chain fatty acids-producing Gram-positive bacteria[J].Acta Pharmaceutica Sinica B,2023,第10期
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Zhijia Wang1,2,Hanxuan Li3,Lantu Gou1,Wei Li3,Yuxi Wang1,2(Department of Pulmonary and Critical Care Medicine,Targeted Tracer Research and Development Laboratory,Institute of Respiratory Health,Frontiers Science Center for Disease-related Molecular Network,National Clinical Research Center for Geriatrics,State Key Laboratory of Biotherapy,Precision Medicine Key Laboratory of Sichuan Province&Precision Medicine Research Center,West China Hospital,Sichuan University;Frontiers Medical Center,Tianfu Jincheng Laboratory;Department of Pharmaceutical Sciences,College of Pharmacy,University of Tennessee Health Science Center).Antibody-drug conjugates:Recent advances in payloads[J].Acta Pharmaceutica Sinica B,2023,第10期
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Jiao Zhang1,Qian Luo1,Qian Hu1,Tiantian Zhang1,Jingyu Shi2,Li Kong1,Dehao Fu3,Conglian Yang1,Zhiping Zhang1,4,5(Tongji School of Pharmacy,Huazhong University of Science and Technology;Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology;Department of Orthopaedics,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine;National Engineering Research Center for Nanomedicine,Huazhong University of Science and Technology;Hubei Engineering Research Center for Novel Drug Delivery System,Huazhong University of Science and Technology).An injectable bioactive dressing based on platelet-rich plasma and nanoclay:Sustained release of deferoxamine to accelerate chronic wound healing[J].Acta Pharmaceutica Sinica B,2023,第10期
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Chao Hou1,2,Dong Wang1,2,Mingxia Zhao1,2,Petek Ballar3,Xinru Zhang1,2,Qiong Mei1,2,Wei Wang1,2,Xiang Li1,2,Qiang Sheng1,2,Jun Liu1,2,Chuansheng Wei1,2,Yujun Shen1,2,Yi Yang1,2,Peng Wang1,2,Juntang Shao1,2,Sa Xu1,2,Fuyan Wang1,2,Yang Sun4,Yuxian Shen1,2(School of Basic Medical Sciences,Anhui Medical University;Biopharmaceutical Research Institute,Anhui Medical University;Department of Biochemistry,Faculty of Pharmacy,Ege University;State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University).MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis[J].Acta Pharmaceutica Sinica B,2023,第10期
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Xiaosen Ouyang1,Willayat Y.Wani1,Gloria A.Benavides1,Matthew J.Redmann1,Hai Vo1,Thomas van Groen2,Victor M.Darley-Usmar1,Jianhua Zhang1,3(Department of Pathology,University of Alabama at Birmingham;Department of Cell,Developmental and Integrative Biology,University of Alabama at Birmingham;Birmingham VA Medical Center,University of Alabama at Birmingham).Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo[J].Acta Pharmaceutica Sinica B,2023,第10期
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Haibin Li1,Lang Sun1,Han Qiao1,Zongti Sun1,Penghe Wang1,Chunyang Xie1,Xinxin Hu1,Tongying Nie1,Xinyi Yang1,Guoqing Li1,Youwen Zhang1,Xiukun Wang1,Zhuorong Li2,Jiandong Jiang1,3,Congran Li1,Xuefu You1(Beijing Key Laboratory of Antimicrobial Agents,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College;Institute of Medicinal Biotechnology,Chinese Academy of Medical Science & Peking Union Medical College;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Science & Peking Union Medical College).Polymyxin resistance caused by large-scale genomic inversion due to IS26 intramolecular translocation in Klebsiella pneumoniae[J].Acta Pharmaceutica Sinica B,2023,第9期
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Thuy Giang Nguyen Cao1,Ji Hee Kang2,Su Jin Kang1,Quan Truong Hoang1,Han Chang Kang3,Won Jong Rhee1,4,Yu Shrike Zhang,Young Tag Ko2,Min Suk Shim1(Division of Bioengineering,Incheon National University;College of Pharmacy,Gachon University;Department of Pharmacy,Integrated Research Institute of Pharmaceutical Sciences,and BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy,College of Pharmacy,the Catholic University of Korea;Research Center for Bio Materials & Process Development,Incheon National University;Division of Engineering in Medicine,Department of Medicine,Brigham and Women’s Hospital,Harvard Medical School).Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood-brain barrier[J].Acta Pharmaceutica Sinica B,2023,第9期
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Hao Tian1,2,Juanfeng Ou1,Yong Wang2,Jia Sun1,Junbin Gao1,Yicheng Ye1,Ruotian Zhang1,Bin Chen1,Fei Wang1,Weichang Huang1,Huaan Li1,2,Lu Liu1,Chuxiao Shao,Zhili Xu4,Fei Peng5,Yingfeng Tu1,2(NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University;Department of Pharmacy,Zhujiang Hospital,Southern Medical University;Key Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui,Central Laboratory of Lishui People’s Hospital,The Sixth Affiliated Hospital of Wenzhou Medical University;Department of Ultrasound,Institute of Ultrasound in Musculoskeletal Sports Medicine,Guangdong Second Provincial General Hospital;School of Materials Science and Engineering,Sun Yat-Sen University).Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment[J].Acta Pharmaceutica Sinica B,2023,第9期
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Dandong Fang1,2,3,Yu Li1,2,Bo He1,2,Daqian Gu1,2,Mingming Zhang1,2,Jingwen Guo1,2,Hongmei Ren1,2,Xinyue Li1,2,Ziyue Zhang1,2,Ming Tang1,2,Xingbing Li1,2,Donghai Yang1,2,Chunmei Xu1,2,Yijie Hu4,Hongyong Wang1,2,Pedro A.Jose5,Yu Han1,2,Chunyu Zeng1,2,6,7(Department of Cardiology,Daping Hospital,the Third Military Medical University (Army Medical University);Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease Research,Ministry of Education of China,Chongqing Key Laboratory for Hypertension Research,Chongqing Cardiovascular Clinical Research Center,Chongqing Institute of Cardiology;Department of Critical Care Medicine,Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University;Department of Cardiac Surgery,Daping Hospital,Third Military Medical University;Division of Renal Disease & Hypertension,the George Washington University School of Medicine & Health Sciences;State Key Laboratory of Trauma,Burns and Combined Injury,Daping Hospital,the Third Military Medical University;Cardiovascular Research Center of Chongqing College,Chinese Academy of Sciences,University of Chinese Academy of Sciences).Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages[J].Acta Pharmaceutica Sinica B,2023,第9期
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Mingcui Luo1,2,Yiwen Yi3,2,Songqiang Huang3,2,Shiyun Dai3,2,Lulu Xie2,4,Kexin Liu2,5,Shuai Zhang1,2,Tao Jiang3,2,Tingting Wang1,2,Baozhen Yao2,4,Hui Wang3,2,Dan Xu1,2(Department of Obstetrics,Zhongnan Hospital of Wuhan University,School of Pharmaceutical Sciences,Wuhan University;Hubei Provincial Key Laboratory of Developmentally Originated Disease;Department of Pharmacology,Taikang Medical School (School of Basic Medical Sciences),Wuhan University;Department of Pediatrics,Renmin Hospital of Wuhan University;Department of Pharmacy,Zhongnan Hospital of Wuhan University).Gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effects[J].Acta Pharmaceutica Sinica B,2023,第9期
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Ling Ye1,Shicheng Fan1,Pengfei Zhao2,Chenghua Wu1,Menghua Liu1,Shuang Hu1,Peng Wang1,Hongyu Wang1,Huichang Bi1(NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University;Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University).Potential herb-drug interactions between anti-COVID-19 drugs and traditional Chinese medicine[J].Acta Pharmaceutica Sinica B,2023,第9期
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Jiafan Yang1,2,Zhenbin Zhou1,2,Yingying Chen1,Yongxiang Song1,2,Jianhua Ju1,2(CAS Key Laboratory of Tropical Marine Bio-resources and Ecology,RNAM Center for Marine Microbiology,Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Chinese Academy of Sciences;University of Chinese Academy of Sciences).Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly[J].Acta Pharmaceutica Sinica B,2023,第9期
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Junjie Yang1,Yue Pan1,Xiaoshan Zeng1,Shuwen Liu1,Zhipeng Chen1,Kui Cheng1,2(Guangdong Provincial Key Laboratory of New Drug Screening and NMPA Key Laboratory for Research and Evaluation of Drug Metabolism,School of Pharmaceutical Sciences,Southern Medical University;Department of Musculoskeletal Oncology,the Third Affiliated Hospital of Southern Medical University).Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation[J].Acta Pharmaceutica Sinica B,2023,第9期
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Huiwen Liu1,Honglan Wang1,Qiyu Li2,Yiwei Wang1,Ying He3,Xuejing Li3,Chunyan Sun1,Onder Ergonul4,Füsun Can4,Zhiqing Pang3,Bo Zhang1,Yu Hu1(Institute of Hematology,Union Hospital,Tongji Medical College,Huazhong University of Science & Technology;Department of Cardiology,Zhongshan Hospital,Fudan University,Shanghai Institute of Cardiovascular Diseases;School of Pharmacy,Fudan University,Key Laboratory of Smart Drug Delivery,Ministry of Education;Koc University Is Bank Center for Infectious Diseases (KUISCID),Lnfectious Diseases and Clinical Microbiology Department,Ko? University School of Medicine and American Hospital).LPS adsorption and inflammation alleviation by polymyxin B-modified liposomes for atherosclerosis treatment[J].Acta Pharmaceutica Sinica B,2023,第9期
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Mei Lu1,2,Haonan Xing2,3,Wanxuan Shao1,Pengfei Wu1,Yuchuan Fan1,Huining He4,Stefan Barth5,Aiping Zheng3,Xing-Jie Liang2,Yuanyu Huang1(Advanced Research Institute of Multidisciplinary Science,School of Life Science,School of Medical Technology,Key Laboratory of Molecular Medicine and Biotherapy,Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering,Beijing Institute of Technology;Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China;State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Institute of Pharmacology and Toxicology;Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics,School of Pharmacy,Tianjin Medical University;South African Research Chair in Cancer Biotechnology,Institute of Infectious Disease and Molecular Medicine(IDM),Department of Integrative Biomedical Sciences,Faculty of Health Sciences,University of Cape Town).Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles[J].Acta Pharmaceutica Sinica B,2023,第9期
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Liming Gong1,2,Heming Zhao1,2,Yanhong Liu1,2,Hao Wu3,Chao Liu1,2,Shuangyan Chang1,2,Liqing Chen1,2,Mingji Jin1,2,Qiming Wang1,2,Zhonggao Gao1,2,Wei Huang1,2(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations,Department of Pharmaceutics,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Department of Pharmacy,Yanbian University).Research advances in peptide-drug conjugates[J].Acta Pharmaceutica Sinica B,2023,第9期
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Yanan Li1,Keqin Li2,Ting Pan1,Qiaobo Xie2,Yuyao Cheng1,Xinfeng Wu2,Rui Xu2,Xiaohui Liu2,Li Liu3,Jiangming Gao3,Wenmin Yuan3,Xianjun Qu2,Shuxiang Cui1(Department of Toxicology and Sanitary Chemistry,Beijing Key Laboratory of Environmental Toxicology,School of Public Health,Capital Medical University;Department of Pharmacology,School of Basic Medical Sciences,Capital Medical University;Department of Pharmacology,Marine Biomedical Research Institute of Qingdao).Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger CaER2+ perturbation in hepatocellular carcinoma[J].Acta Pharmaceutica Sinica B,2023,第9期
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Jiawei Wu,Liyun Xing,Yaxian Zheng,Yinglan Yu,Ruinan Wu,Xi Liu,Lian Li,Yuan Huang(Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University).Disease-specific protein corona formed in pathological intestine enhances the oral absorption of nanoparticles[J].Acta Pharmaceutica Sinica B,2023,第9期
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Hanyu Yang1,2,Mengxiang Su3,Ming Liu2,Yun Sheng2,Liang Zhu2,Lu Yang1,2,Ruijing Mu1,2,Jianjun Zou4,Xiaodong Liu1,2,Li Liu1,2(State Key Laboratory of Natural Medicines,Key Laboratory of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University;Department of Pharmacology,School of Pharmacy,China Pharmaceutical University;Department of Pharmaceutical Analysis,School of Pharmacy,China Pharmaceutical University;Department of Clinical Pharmacology,Nanjing First Hospital,Nanjing Medical University).Hepatic retinaldehyde deficiency is involved in diabetes deterioration by enhancing PCK1-and G6PC-mediated gluconeogenesis[J].Acta Pharmaceutica Sinica B,2023,第9期
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Yanze Sun1,2,3,Xinmiao Yu1,2,3,Xiao Wang1,2,3,Kai Yuan1,2,3,Gefei Wang1,2,3,Lingrong Hu1,2,3,Guoyu Zhang1,2,3,Wenli Pei1,2,3,Liping Wang1,2,3,Chengliang Sun1,2,3,Peng Yang1,2,3(State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization,China Pharmaceutical University;Department of Medicinal Chemistry,School of Pharmacy,China Pharmaceutical University;Institute of Innovative Drug Discovery and Development,China Pharmaceutical University).Bispecific antibodies in cancer therapy:Target selection and regulatory requirements[J].Acta Pharmaceutica Sinica B,2023,第9期
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Wei Cong1,Huaxing Shen1,Xiufei Liao2,3,Mengjun Zheng2,Xianglong Kong1,Zhe Wang4,Si Chen1,Yulei Li5,Honggang Hu1,Xiang Li2(School of Medicine Or Institute of Translational Medicine,Shanghai University;School of Pharmacy,Second Military Medical University;Tarim University;Institute of Bioengineering,College of Chemical and Biological Engineering,Zhejiang University;School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica,Shandong First Medical University & Shandong Academy of Medical Sciences,NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences),Key Lab for Rare & Uncommon Diseases of Shandong Province).Discovery of an orally effective double-stapled peptide for reducing ovariectomy-induced bone loss in mice[J].Acta Pharmaceutica Sinica B,2023,第9期
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Chen Li1,2,Jiayan Lang1,2,Yazhou Wang3,Zhaoxia Cheng1,4,Mali Zu1,2,Fenfen Li1,5,Jingyi Sun1,2,Yating Deng1,2,Tianjiao Ji1,2,Guangjun Nie1,2,Ying Zhao1,2(CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety,CAS Center of Excellence in Nanoscience,National Center for Nanoscience and Technology;Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences;Pancreas Centre,the First Affiliated Hospital of Nanjing Medical University;Green Catalysis Center,and College of Chemistry,Zhengzhou University;School of Basic Medical Sciences,Zhengzhou University).Self-assembly of CXCR4 antagonist peptide-docetaxel conjugates for breast tumor multi-organ metastasis inhibition[J].Acta Pharmaceutica Sinica B,2023,第9期
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Hongjuan Zhao1,2,3,Yatong Li1,Beibei Zhao1,Cuixia Zheng1,2,Mengya Niu1,Qingling Song1,Xinxin Liu4,5,Qianhua Feng1,2,Zhenzhong Zhang1,2,Lei Wang1,2,5(School of Pharmaceutical Sciences,Zhengzhou University;Key Laboratory of Advanced Pharmaceutical Technology,Ministry of Education of China,Zhengzhou University;Biotherapy Center,the First Affiliated Hospital of Zhengzhou University,Zhengzhou University;Luoyang Central Hospital Affiliated to Zhengzhou University;Tumor Immunity and Biomaterials Advanced Medical Center,Zhengzhou University).Orchestrating antigen delivery and presentation efficiency in lymph node by nanoparticle shape for immune response[J].Acta Pharmaceutica Sinica B,2023,第9期
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