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Nana Zhang1,Haibo Zhu1,Zijian Li2,Erdan Dong2(State Key Laboratory for Bioactive Substances and Functions of Natural Medicines,Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,Key Laboratory of Cardiovascular Receptors Research,Beijing,Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education,Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Ministry of Health).A novel β2-AR agonist, Higenamine, induces β-arrestin-biased signaling[J].Science China(Life Sciences),2022,第7期
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Meng Xiao1,2,Bo Lu3,4,Rui Ding1,2,Xia Liu5,Xian Wu1,2,Yaqian Li6,Xudong Liu6,Lin Qiu5,Zhibo Zhang5,Jing Xie7,Yu Chen1,2,Dong Zhang1,2,Liting Dong3,4,Meiling Zhang3,Jinying Peng3,Hua Yang5,Timothy Kudihna8,9,Yingchun Xu1,2,Taisheng Li7,Chengqi Yi3,4,Lan Zhu5(Department of Laboratory Medicine,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences;Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases;State Key Laboratory of Protein and Plant Gene Research,School of Life Sciences,Peking University;Peking-Tsinghua Center for Life Sciences,Peking University;Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences;Medical Science Research Center,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College;Department of Infectious Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College;School of Biomedical Sciences,Charles Sturt University;NSW Health Pathology,Regional and Rural,Orange Hospital).Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19[J].Science China(Life Sciences),2022,第7期
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Changlin Wang1,2,Mei Xue3,Peng Wu1,2,Honglei Wang1,2,Zhongqing Liu1,2,Guangzheng Wu1,2,Pinghuang Liu3,Keliang Wang1,2,Wanhai Xu1,2,Li Feng3(Department of Urology,the Fourth Affiliated Hospital of Harbin Medical University;NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy,Harbin Medical University;State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences).Coronavirus transmissible gastroenteritis virus antagonizes the antiviral effect of the microRNA miR-27b via the IRE1 pathway[J].Science China(Life Sciences),2022,第7期
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Hui Zhao1,2,Jianping Zhao3,Di Wu4,Zhaolin Sun3,Yang Hua4,Min Zheng3,Yumei Liu4,Qi Yang4,Xiahe Huang1,Yuan Li3,Yueshan Piao4,Yingchun Wang1,Sin Man Lam1,Huijuan Xu1,Guanghou Shui1,Yongjun Wang5,Haifeng Yao6,Liangxue Lai2,Zhuo Du1,Jidong Mi3,Enqi Liu7,Xunming Ji4,Yong Q.Zhang1(Key Laboratory of Molecular Developmental Biology,and CAS Center for Excellence in Brain Science and Intelligence Technology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences;Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences;Beijing Sinogene Biotechnology Co.Ltd;Xuanwu Hospital,Capital Medical University;Tian Tan Hospital,Capital Medical University;Beijing Petsguard Animal Hospital;Laboratory Animal Center,Xi'an Jiaotong University Health Science Center).Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications[J].Science China(Life Sciences),2022,第7期
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Zi-Yuan Feng,Qing-Yi Zhang,Jie Tan,Hui-Qi Xie(Laboratory of Stem Cell and Tissue Engineering,Orthopedic Research Institute,Med-X Center for Materials,State Key Laboratory of Biotherapy,West China Hospital,Sichuan University).Techniques for increasing the yield of stem cell-derived exosomes:what factors may be involved?[J].Science China(Life Sciences),2022,第7期
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Xiaoxue Wang1,Jiaxiang Hu1,Linfei Song1,Enguang Rong1,Chenghuai Yang2,Xiaoyun Chen2,Juan Pu3,Honglei Sun3,Chuze Gao1,David W.Burt4,Jinhua Liu3,Ning Li1,Yinhua Huang1(State Key Laboratory for Agrobiotechnology,College of Biology Sciences,China Agricultural University;China Institute of Veterinary Drug Control;Key Laboratory of Animal Epidemiology and Zoonosis,Ministry of Agriculture,College of Veterinary Medicine,China Agricultural University;University of Queensland).Functional divergence of oligoadenylate synthetase 1(OAS1) proteins in Tetrapods[J].Science China(Life Sciences),2022,第7期
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Lijia Jia1,Meng Xu1,2,Mengchan Hao1,2,Di Liu1,2,Haizhou Liu1,Xin Zheng3,Jianjun Chen1(CAS Key Laboratory of Special Pathogens,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Department of Infectious Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology).Comparison of microbial composition and diversity in the upper respiratory tract between SARS-CoV-2 and influenza virus infections[J].Science China(Life Sciences),2022,第7期
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Ruicheng Dai1,2,3,Tao Yu4,1,3,Danwei Weng5,1,Heng Li4,1,6,Yuting Cui1,Zhaofa Wu7,8,Qingchun Guo9,10,Haiyue Zou11,10,Wenting Wu4,1,3,Xinwei Gao10,Zhongyang Qi1,Yuqi Ren1,Shu Wang10,Yulong Li7,8,Minmin Luo1,5,10,6(National Institute of Biological Sciences (NIBS);School of Life Sciences,Peking University;Peking University-Tsinghua University-NIBS Joint Graduate Program,NIBS;School of Life Sciences,Tsinghua University;Graduate School of Peking Union Medical College;Tsinghua Institute of Multidisciplinary Biomedical Research (TIMBR);State Key Laboratory of Membrane Biology,Peking University School of Life Sciences;PKU-McGovern Institute for Brain Research;Capital Medical University;Chinese Institute for Brain Research;Academy for Advanced Interdisciplinary Studies,Peking University).A neuropsin-based optogenetic tool for precise control of Gq signaling[J].Science China(Life Sciences),2022,第7期
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Man Wang1,2,Jiehu Chen3,Feng Zhou1,2,Jianming Yuan1,2,Libin Chen1,2,Rongling Wu4,Yaoguang Liu1,2,5,Qunyu Zhang1,2,5(State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources,College of Life Sciences,South China Agricultural University;Guangdong Laboratory for Lingnan Modern Agriculture;Science Corporation of Gene;Center for Statistical Genetics,The Pennsylvania State University;SCAU Main Campus Teaching & Research Base).The ties of brotherhood between japonica and indica rice for regional adaptation[J].Science China(Life Sciences),2022,第7期
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Lina Li1,Canxing Duan1,Jianfeng Weng1,Xiantao Qi1,Changlin Liu1,Xinhai Li1,2,Jinjie Zhu1,Chuanxiao Xie1(National Key Facility for Crop Gene Resources and Genetic Improvement,Institute of Crop Science,Chinese Academy of Agricultural Sciences (CAAS);Biotechnology Research Institute,Chinese Academy of Agricultural Sciences (CAAS)).A field-deployable method for single and multiplex detection of DNA or RNA from pathogens using Cas12 and Cas13[J].Science China(Life Sciences),2022,第7期
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Xinyi Guo1,Chen Dong1,2(Institute for Immunology and School of Medicine,Tsinghua University;Shanghai Immune Therapy Institute,Shanghai Jiaotong University School of Medicine-affiliated Renji Hospital).Zooming on T cells in cancer[J].Science China(Life Sciences),2022,第7期
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Zhi Ping1,2,3,Huanming Yang1,3,Yue Shen1,2,3,4(BGI-Shenzhen;Guangdong Provincial Key Laboratory of Genome Read and Write,BGI-Shenzhen;George Church Institute of Regenesis,BGI-Shenzhen;Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences).A new era of mass data storage in artificial chromosome[J].中国科学(生命科学英文版),2022,第7期
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Yucheng Liu1,Zhixi Tian1,2(State Key Laboratory of Plant Cell and Chromosome Engineering,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences;University of Chinese Academy of Sciences).Convergent selection of a gene in cereals leads to grain yield upgradation[J].Science China(Life Sciences),2022,第7期
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Xi-Yin Li1,Jie Mei2,Chu-Tian Ge3,Xiao-Li Liu4,Jian-Fang Gui1(State Key Laboratory of Freshwater Ecology and Biotechnology,Hubei Hongshan Laboratory,The Innovative Academy of Seed Design,Institute of Hydrobiology,Chinese Academy of Sciences,University of Chinese Academy of Sciences;College of Fisheries,Hubei Hongshan Laboratory,Huazhong Agricultural University;College of Biological and Environmental Sciences,Zhejiang Wanli University;Key Laboratory of Tropical & Subtropical Fishery Resource Application & Cultivation of Ministry of Agriculture and Rural Affairs,Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences).Sex determination mechanisms and sex control approaches in aquaculture animals[J].Science China(Life Sciences),2022,第6期
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Qi Zhang1,2,Danyang Li1,3,Xue Dong1,Xiaowen Zhang1,Junwu Liu1,Lili Peng1,Bo Meng1,Qi Hua1,3,Xinyu Pei1,Lu Zhao1,Xiaoxi Hu1,Yang Zhang1,Zhenwei Pan1,Yanjie Lu1,3,4,Baofeng Yang1,4(Department of Pharmacology,State-Province Key Laboratories of Biomedicine-Pharmaceutics of China,Key Laboratory of Cardiovascular Medicine Research,Ministry of Education,College of Pharmacy,Harbin Medical University;College of Pharmacy,Qiqihar Medical University;Translational Medicine Research and Cooperation Center of Northern China,Heilongjiang Academy of Medical Sciences,Harbin Medical University;Research Unit of Noninfectious Chronic Diseases in Frigid Zone (2019RU070),Chinese Academy of Medical Sciences).LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy[J].Science China(Life Sciences),2022,第6期
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Xiaodan Liao1,2,Zhongpu Zhao1,2,Hui Li3,Bo Wu1,Jiawei Huo1,2,Lei Li1,2,Xue Li1,Xinran Cao1,2,Min Xia3,Chunru Wang1,Chunli Bai1(Beijing National Laboratory for Molecular Sciences,Key Laboratory of Molecular Nanostructure and Nanotechnology,CAS Research/Education Center for Excellence in Molecular Sciences,Institute of Chemistry,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Beijing FULLCAN Biotechnology Co.,Ltd.).Fullerene nanoparticles for the treatment of ulcerative colitis[J].Science China(Life Sciences),2022,第6期
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Mingwei Cai1,Changhai Duan2,1,Xinxu Zhang1,Jie Pan1,Yang Liu1,Cuijing Zhang1,Meng Li1,2(Archaeal Biology Center,Shenzhen Key Laboratory of Marine Microbiome Engineering,Institute for Advanced Study,Shenzhen University;SZU-HKUST Joint Ph D Program in Marine Environmental Science,Shenzhen University).Genomic and transcriptomic dissection of Theionarchaea in marine ecosystem[J].Science China(Life Sciences),2022,第6期
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Mei-Ling Gao1,Xiao Zhang2,Fang Han2,Jia Xu2,Si-Jian Yu2,Kangxin Jin2,Zi-Bing Jin2(Institute of Stem Cell Research,The Eye Hospital,Wenzhou Medical University;Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology & Visual Sciences Key Laboratory).Functional microglia derived from human pluripotent stem cells empower retinal organs[J].Science China(Life Sciences),2022,第6期
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Huajuan Ma1,Haijun Wen2,Yaoxu Qin2,Shijie Wu2,Ge Zhang1,Chung-I Wu2,Qichun Cai1(Cancer Center,Clifford Hospital,Jinan University;State Key Laboratory of Biocontrol,School of Life Sciences,Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai),Sun Yat-sen University).Homo-harringtonine,highly effective against coronaviruses,is safe in treating COVID-19 by nebulization[J].Science China(Life Sciences),2022,第6期
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Lu Luo1,Jun Yang1,Cheng Wang2,Jie Wu1,Yafang Li3,Xu Zhang4,Hui Li5,Hui Zhang6,Yumei Zhou7,Aiping Lu8,Shilin Chen1(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences & Peking Union Medical College;Institute of Hematology & Blood Diseases Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;we MED Health;Institute of Botany,Chinese Academy of Sciences;Akupunktur Akademiet;The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine;School of Chinese Medicine,Hong Kong Baptist University).Natural products for infectious microbes and diseases:an overview of sources,compounds,and chemical diversities[J].Science China(Life Sciences),2022,第6期
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Dingbin Gong1,2,Min Tao1,2,Lihui Xu1,2,Fangzhou Hu1,2,Zehong Wei1,2,Shi Wang1,2,Yude Wang1,2,Qingfeng Liu1,2,Chang Wu1,2,Kaikun Luo1,2,Chenchen Tang1,2,Rong Zhou1,2,Chun Zhang1,2,Yuequn Wang1,2,Shaojun Liu1,2(State Key Laboratory of Developmental Biology of Freshwater Fish,Hunan Normal University;College of Life Sciences,Hunan Normal University).An improved hybrid bream derived from a hybrid lineage of Megalobrama amblycephala(♀)×Culter alburnus(♂)[J].Science China(Life Sciences),2022,第6期
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Haoran Peng1,Cuiling Ding1,Liangliang Jiang1,Wanda Tang1,Yan Liu1,Lanjuan Zhao1,Zhigang Yi2,Hao Ren1,Chong Li3,Yanhua He1,Xu Zheng1,Hailin Tang1,Zhihui Chen4,Zhongtian Qi1,Ping Zhao1(Department of Microbiology,Second Military Medical University,Shanghai Key Laboratory of Medical Biodefense;Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS),School of Basic Medical Sciences,Shanghai Medical College,Fudan University;Cancer Institute,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University;Department of Infectious Disease,Changhai Hospital).Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo[J].Science China(Life Sciences),2022,第6期
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Ronghui Che1,2,Bin Hu1,3,Wei Wang1,3,Yunhua Xiao1,Dapu Liu4,Wenchao Yin4,Hongning Tong4,Chengcai Chu1(State Key Laboratory of Plant Genomics,Institute of Genetics and Developmental Biology,the Innovative Academy for Seed Design,Chinese Academy of Sciences;School of Biological and Science Technology,University of Jinan;College of Agriculture,South China Agricultural University;National Key Facility for Crop Gene Resources and Genetic Improvement,Institute of Crop Sciences,Chinese Academy of Agricultural Sciences).POLLEN STERILITY,a novel suppressor of cell division,is required for timely tapetal programmed cell death in rice[J].Science China(Life Sciences),2022,第6期
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Han Feng1,Xiaohong Zhao1,Jenny Xie2,Xue Bai1,Weiwei Fu1,3,Hairong Chen4,Hong Tang4,5,6,Xiaohu Wang1,Chen Dong1,7(Institute for Immunology,Tsinghua University;Discovery Immunology,Bristol Myers Squibb;Department of Gastroenterology,Peking University Third Hospital;CAS Key Laboratory of Infection and Immunity,Institute of Biophysics,Chinese Academy of Science;CAS Key Laboratory of Molecular Virology and Immunology,Institute Pasteur of Shanghai,Chinese Academy of Sciences;Pasteurien College,Suzhou University;Shanghai Immune Therapy Institute,Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital).Pathogen-associated T follicular helper cell plasticity is critical in anti-viral immunity[J].Science China(Life Sciences),2022,第6期
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Bai Xue1,Ping Wang2,Wenzhen Yu3,Jing Feng2,Jie Li4,Rulian Zhao1,Zhenglin Yang1,5,Xiyun Yan2,6,7,Hongxia Duan2(Sichuan Provincial Key Laboratory for Human Disease Gene Study,Sichuan Provincial People's Hospital,School of Medicine,University of Electronic Science and Technology of China;Key Laboratory of Protein and Peptide Pharmaceutical,Institute of Biophysics,Chinese Academy of Sciences;Department of Ophthalmology,People's Hospital,Peking University;Department of Ophthalmology,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China;Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026),Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital;Nanozyme Medical Center,School of Basic Medical Sciences,Zhengzhou University;College of Life Sciences,University of Chinese Academy of Sciences).CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases[J].Science China(Life Sciences),2022,第6期
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Hong Li1,2,Wenyan Gao1,Yifan Cui1,2,Yuanyuan Pan1,Gang Liu1,2,3(State Key Laboratory of Mycology,Institute of Microbiology,Chinese Academy of Sciences;University of Chinese Academy of Sciences;The Innovative Academy of Seed Design,Chinese Academy of Sciences).Remarkable enhancement of bleomycin production through precise amplification of its biosynthetic gene cluster in Streptomyces verticillus[J].Science China(Life Sciences),2022,第6期
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Mengmeng Cui1,Ghulam Abbas1,2,Dianbing Wang1,Qian Liu1,Rui Gong1,2,Min Li1,Xian-En Zhang1,3,2(National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Faculty of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences).Genetically encoded redox biosensor system for H2O2 measurement in four subcellular compartments in acute myeloid leukemia(AML) cells[J].Science China(Life Sciences),2022,第6期
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Bin Yan1,Xiaofeng Cao1,2,3(State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing),Institute of Genetics and Developmental Biology,Chinese Academy of Sciences;Center for Excellence in Molecular Plant Sciences,Chinese Academy of Sciences;University of Chinese Academy of Sciences).Thermotolerance in rice[J].Science China(Life Sciences),2022,第6期
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Xiangxiang Liu1,2,3,Mohamed M.Khodeiry2,4,Danting Lin1,3,Yunxiao Sun1,3,Qing Zhang1,3,Jiawei Wang5,Richard K.Lee2,Ningli Wang1,3(Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University;Bascom Palmer Eye Institute,University of Miami Miller School of Medicine;Beijing Ophthalmology and Visual Science Key Laboratory,Beijing Eye Institute;Research institute of Ophthalmology;Department of Neurology and Medical Research Center,Beijing Tongren Hospital,Capital Medical University).The association of cerebrospinal fluid pressure with optic nerve head and macular vessel density[J].Science China(Life Sciences),2022,第6期
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Jinglin Zhu1,2,Xun Huang1,2(State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences;University of Chinese Academy of Sciences).Endocrine function of pheromones couples fat rationing and nutrient scarcity[J].Science China(Life Sciences),2022,第6期
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