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Ming-cheng Yu,Feng Yang,Xiao-yu Ding,Nan-nan Sun,Zheng-yuan Jiang,Ya-fei Huang,Yu-rong Yan,Chen Zhu,Qiong Xie,Zhi-feng Chen,Si-qi Guo,Hua-liang Jiang,Kai-xian Chen,Cheng Luo,Xiao-min Luo,Shi-jie Chen,Yong-hui Wang(Department of Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 201203,China;Department of Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 201203,China;Drug Discovery and Design Center,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China;Drug Discovery and Design Center,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Department of Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 201203,China;Key Laboratory of Metabolism and Molecular Medicine,The Ministry of Education,Department of Biochemistry and Molecular Biology,Shanghai Medical College,Fudan University,Shanghai 200032,China;Department of Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 201203,China;Fudan Zhangjiang Institute,Shanghai 201203,China;Drug Discovery and Design Center,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China;Drug Discovery and Design Center,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;School of Pharmaceutical Science and Technology,Hangzhou Institute for Advanced Study,UCAS,Hangzhou 310024,China).Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators:insights into different protein behaviors with "short" and"long" inverse agonists[J].中国药理学报(英文版),2021,第9期
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Yuan-dong Zheng,Hua Zhang,Yan Zhan,Yi-cong Bian,Sheng Ma,Hai-xian Gan,Xiao-juan Lai,Yong-qiang Liu,Yan-chun Gong,Xue-fang Liu,Hong-bin Sun,Yong-guo Li,Da-fang Zhong,Li-yan Miao,Xing-xing Diao(State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201210,China;University of Chinese Academy of Sciences,Beijing 100049,China;Department of Clinical Pharmacology,the First Affiliated Hospital of Soochow University,Suzhou 215123,China;Institute for Interdisciplinary Drug Research and Translational Sciences,Soochow University,Suzhou 215006,China;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201210,China;Jiangsu Vcare PharmaTech Co.Ltd.,Nanjing 211800,China;State Key Laboratory of Natural Medicines and Center of Drug Discovery,College of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Guangzhou JOYO Pharma Ltd.,Shanghai 201203,China).Pharmacokinetics,mass balance,and metabolism of[14C]vicagrel,a novel irreversible P2Y12 inhibitor in humans[J].中国药理学报(英文版),2021,第9期
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Yang Xiong,Chu Shifeng,Wang Zhenzhen,Li Fangfang,Yuan Yuhe,Chen Naihong.Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-kappaB pathways in the striatum[J].中国药理学报,2021,第9期
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Ran Li,Chang-qiong Xu,Jian-xin Shen,Qiu-yun Ren,Di-ling Chen,Mian-jie Lin,Rong-ni Huang,Chun-hui Li,Ru-ting Zhong,Zhi-hua Luo,Xiao-yu Ji,Jie Wu(Brain Function and Disease Laboratory,Shantou University Medical College,Shantou 515041,China;Guangdong Institute of Microbiology,Guangzhou 510070,China;Yueyang Hospital of Traditional Chinese Medicine,Yueyang 414000,China).4-Methoxydalbergione is a potent inhibitor of human astroglioma U87 cells in vitro and in vivo[J].中国药理学报(英文版),2021,第9期
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Zhang Feng,Zhong Rujia,Cheng Cheng,Li Song,Le Weidong.New therapeutics beyond amyloid-beta and tau for the treatment of Alzheimer's disease[J].中国药理学报,2021,第9期
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Yu Mingcheng,Yang Feng,Ding Xiaoyu,Sun Nannan,Jiang Zhengyuan,Huang Yafei,Yan Yurong,Zhu Chen,Xie Qiong,Chen Zhifeng,Guo Siqi,Jiang Hualiang,Chen Kaixian,Luo Cheng,Luo Xiaomin,Chen Shijie,Wang Yonghui.Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORgammat)modulators:insights into different protein behaviors with "short" and "long" inverse agonists[J].中国药理学报,2021,第9期
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Zhang Chanjuan,Zhu Neng,Long Jia,Wu Hongtao,Wang Yuxiang,Liu Biyuan,Liao Duanfang,Qin Li(Division of Stem Cell Regulation and Application,School of Pharmacy,Hunan University of Chinese Medicine;Department of Urology,The First Hospital of Hunan University of Chinese Medicine;Department of Urology,The Second XiangYa Hospital of Central South University;Department of Immunology,School of Medicine,Hunan University of Chinese Medicine).Celastrol induces lipophagy via the LXRalpha/ABCAl pathway in clear cell renal cell carcinoma[J].中国药理学报,2021,第9期
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Lei Zhu,Xiao-jie Hou,Xiao-hang Che,Ting-shuo Zhou,Xiao-qi Liu,Chun-fu Wu,Jing-yu Yang(Department of Pharmacology,Shenyang Pharmaceutical University,Shenyang 110016,China).Pseudoginsenoside-F11 attenuates cognitive dysfunction and tau phosphorylation in sporadic Alzheimer's disease rat model[J].中国药理学报(英文版),2021,第9期
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Ning Zhu,Xiu-juan Zhang,Hai Zou,Yuan-yuan Zhang,Jing-wen Xia,Peng Zhang,You-zhi Zhang,Jing Li,Liang Dong,Gulinuer Wumaier,Sheng-qing Li(Department of Pulmonary and Critical Care Medicine,Huashan Hospital,Fudan University,Shanghai 200040,China).PTPL1 suppresses lung cancer cell migration via inhibiting TGF-β1-induced activation of p38 MAPK and Smad 2/3 pathways and EMT[J].中国药理学报(英文版),2021,第8期
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Hyun-Soo Park,Joo-Hui Han,Jeong Won Park,Do-Hyung Lee,Keun-Woo Jang,Miji Lee,Kyung-Sun Heo,Chang-Seon Myung(Department of Pharmacology,Chungnam National University College of Pharmacy,Daejeon 34134,Republic of Korea;Department of Lifetech.lnstitute,iNtRON Biotechnology,Seongnam-si 13202,Republic of Korea).Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling[J].中国药理学报(英文版),2021,第8期
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Chuan He,Shan Lu,Xuan-zhong Wang,Chong-cheng Wang,Lei Wang,Shi-peng Liang,Tian-fei Luo,Zhen-chuan Wang,Mei-hua Piao,Guang-fan Chi,Peng-fei Ge(Department of Neurosurgery,First Hospital of Jilin University,Changchun 130021,China;Research Center of Neuroscience,First Hospital of Jilin University,Changchun 130021,China;Research Center of Neuroscience,First Hospital of Jilin University,Changchun 130021,China;Department of Neurology,First Hospital of Jilin University,Changchun 130021,China;Department of Anesthesiology,First hospital of Jilin University,Changchun 130021,China;Key Laboratory of Pathobiology,Ministry of Education,Jilin University,Changchun 130021,China).FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy[J].中国药理学报(英文版),2021,第8期
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Lin Zhu,Chun-yuan Zhang,Dong-ping Li,Hu-biao Chen,Jiang Ma,Hong Gao,Yang Ye,Ji-yao Wang,Peter P.Fu,Ge Lin(School of Biomedical Sciences,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China;Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between The Chinese University of Hong Kong and Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Beijing 201203,China;Division of Gastroenterology,Zhongshan Hospital,Fudan University,Shanghai 201203,China;School of Chinese Medicine,Hong Kong Baptist University,Hong Kong SAR,China;Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between The Chinese University of Hong Kong and Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Beijing 201203,China;State Key Laboratory of Drug Research and Natural Products Chemistry Department,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;National Center for ToxicoloGical Research,USA Food and Drug Administration,Jefferson,AR 72079,USA).Tu-San-Qi(Gynura japonica):the culprit behind pyrrolizidine alkaloid-induced liver injury in China[J].中国药理学报(英文版),2021,第8期
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Xue-gong Fan,Si-ya Pei,Dan Zhou,Peng-cheng Zhou,Yan Huang,Xing-wang Hu,Teng Li,Yang Wang,Ze-bing Huang,Ning Li(Viral hepatitis of Hunan Key Laboratory and Department of Infectious Disease,Xiangya Hospital,Central South University,Changsha 410008,China;Institute of Integrative Medicine,Xiangya Hospital,Central South University,Changsha 410008,China;Viral hepatitis of Hunan Key Laboratory and Department of Infectious Disease,Xiangya Hospital,Central South University,Changsha 410008,China;Institute of Integrative Medicine,Xiangya Hospital,Central South University,Changsha 410008,China;Viral hepatitis of Hunan Key Laboratory and Department of Infectious Disease,Xiangya Hospital,Central South University,Changsha 410008,China;Department of Blood Transfusion,Xiangya Hospital,Central South University,Changsha 410008,China).Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect[J].中国药理学报(英文版),2021,第8期
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Li Yang,Rong-juan Pei,Heng Li,Xin-na Ma,Yu Zhou,Feng-hua Zhu,Pei-Ian He,Wei Tang,Ye-cheng Zhang,Jin Xiong,Shu-qi Xiao,Xian-kun Tong,Bo Zhang,Jian-ping Zuo(Laboratory of Immunopharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Key Laboratory of Special Pathogens and Biosafety,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan 430071,China;Laboratory of Immunopharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China;Laboratory of Immunology and Virology,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Laboratory of Immunopharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China;Laboratory of Immunology and Virology,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China).Identification of SARS-CoV-2 entry inhibitors among already approved drugs[J].中国药理学报(英文版),2021,第8期
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Ting-ting Fu,Gao Tu,Meng Ping,Guo-xun Zheng,Feng-yuan Yang,Jing-yi Yang,Yang Zhang,Xiao-jun Yao,Wei-wei Xue,Feng Zhu(School of Pharmaceutical Sciences,Collaborative Innovation Center for Brain Science and Chongqing Key Laboratory of Natural Product Synthesis and Drug Research,Chongqing University,Chongqing 401331,China;College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;School of Pharmaceutical Sciences,Collaborative Innovation Center for Brain Science and Chongqing Key Laboratory of Natural Product Synthesis and Drug Research,Chongqing University,Chongqing 401331,China;State Key Laboratory of Applied Organic Chemistry and Department of Chemistry,Lanzhou University,Lanzhou 730000,China).Subtype-selective mechanisms of negative allosteric modulators binding to group Ⅰ metabotropic glutamate receptors[J].中国药理学报(英文版),2021,第8期
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Tong Sun,Yu-jia Xu,Shuo-yi Jiang,Zhuan Xu,Bi-yin Cao,Gautam Sethi,Yuan-ying Zeng,Yan Kong,Xin-liang Mao(Department of Pharmacology,Soochow University,Suzhou 215123,China;Department of Neurology,the First Affiliated Hospital of Soochow University,Suzhou 215100,China;Department of Pharmacology,Soochow University,Suzhou 215123,China;Guangdong Key Laboratory of Protein Modifications and Degradation,School of Basic Medicine,Guangzhou Medical University,Guangzhou 511436,China;Department of Pharmacology,Soochow University,Suzhou 215123,China;Department of Neurology,the First Affiliated Hospital of Soochow University,Suzhou 215100,China;Department of Pharmacology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 117600,Singapore;Department of Oncology,Suzhou Municipal Hospital,Suzhou 215100,China;Department of Pharmacology,Soochow University,Suzhou 215123,China;Guangdong Key Laboratory of Protein Modifications and Degradation,School of Basic Medicine,Guangzhou Medical University,Guangzhou 511436,China;Institute of Clinical Pharmacology,Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou 510405,China).Suppression of the USP10/CCND1 axis induces glioblastoma cell apoptosis[J].中国药理学报(英文版),2021,第8期
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Ling-lei Kong,Li Gao,Ke-xin Wang,Nan-nan Liu,Cheng-di Liu,Guo-dong Ma,Hai-guang Yang,Xue-mei Qin,Guan-hua Du(Beijing Key Laboratory of Drug Targets Identification and Drug Screening,Centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China;Guangdong Pharmaceutical University,Guangzhou 510006,China).Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites[J].中国药理学报(英文版),2021,第8期
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De-juan Li,Qin Yue,Lu Liu,Ke-ke Che,Xue-mei Liu,Chang-hua Hu(College of Pharmaceutical Sciences,Medical Research Institute,Southwest University,Chongqing 400715,China;College of Pharmaceutical Sciences,Medical Research Institute,Southwest University,Chongqing 400715,China;School of Medical Sciences,North Sichuan Medical College,Nanchong 637000,China).Brexpiprazole caused glycolipid metabolic disorder by inhibiting GLP1/GLP1R signaling in rats[J].Acta Pharmacologica Sinica,2021,第8期
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Zhu Ning,Zhang Xiujuan,Zou Hai,Zhang Yuanyuan,Xia Jingwen,Zhang Peng,Zhang Youzhi,Li Jing,Dong Liang,Wumaier Gulinuer,Li Shengqing.PTPL1 suppresses lung cancer cell migration via inhibiting TGF-beta1-induced activation of p38 MAPK and Smad 2/3 pathways and EMT[J].中国药理学报,2021,第8期
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Yan-yan Zhao,Jing Jia,Jing-jing Zhang,Yan-ping Xun,Shu-jun Xie,Jia-feng Liang,Hong-gang Guo,Jia-zhen Zhu,Sheng-lin Ma,Shi-rong Zhang(Department of Translation Medicine Center,Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China;Center for Molecular Medicine,Zhejiang Academy of Medical Sciences,Hangzhou 310006,China;College of Pharmaceutical Science,Zhejiang Chinese Medical University,Hangzhou 310006,China;Department of Translation Medicine Center,Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China;Department of Oncology,Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China).Inhibition of histamine receptor H3 suppresses the growth and metastasis of human non-small cell lung cancer cells via inhibiting PI3K/Akt/mTOR and MEK/ERK signaling pathways and blocking EMT[J].中国药理学报(英文版),2021,第8期
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He-ling Niu,Ya-ni Liu,Deng-qi Xue,Li-ying Dong,Hui-jie Liu,Jing Wang,Yi-lin Zheng,An-ruo Zou,Li-ming Shao,KeWei Wang(Department of Pharmacology,School of Pharmacy,Qingdao University,Qingdao 266073,China;School of Pharmacy,Fudan University,Shanghai 201203,China;Institute of Innovative Drug,Qingdao University,Qingdao 266021,China;Department of Pharmacology,School of Pharmacy,Qingdao University,Qingdao 266073,China;Institute of Innovative Drug,Qingdao University,Qingdao 266021,China;Center for Brain Science and Brain-Inspired Intelligence,Guangdong-Hong Kong-Macao Greater Bay Area,Tamar,Hong Kong,China).Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain[J].中国药理学报(英文版),2021,第8期
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Chen-yu Wang,Chang-cheng Sheng,Guang-li Ma,Da Xu,Xiao-qin Liu,Yu-ya Wang,Li Zhang,Chuan-liang Cui,Bing-he Xu,Yu-qin Song,Jun Zhu,Zheng Jiao(Department of Pharmacy,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,China;Department of Pharmacy,Guizhou Provincial People's Hospital,Guiyang 550002,China;Department of Clinical Pharmacology,Jiangsu Hengrui Medicine Co.Ltd,Shanghai 222047,China;Department of Pharmacy,Huashan Hospital,Fudan University,Shanghai 200041,China;Department of Medical Oncology,Sun Yat-sen University Cancer Center,Guangzhou 510060,China;Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Renal Cancer and Melanoma,Peking University Cancer Hospital&Institute,Beijing 100036,China;Department of Medical Oncology,National Cancer Hospital,Chinese Academy of Medical Sciences,Beijing 100021,China;Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Department of Lymphoma,Peking University Cancer Hospital&Institute,Beijing 100036,China).Population pharmacokinetics of the anti-PD-1 antibody camrelizumab in patients with multiple tumor types and model-informed dosing strategy[J].中国药理学报(英文版),2021,第8期
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Bao-ming Wu,Jaree Bargaineer,Ling Zhang,Tao Yang,Zhi-gang Xiong,Tian-dong Leng(Department of Neurobiology,Neuroscience Institute,Morehouse School of Medicine,Atlanta,GA 30310,USA).Upregulation of acid sensing ion channel 1a(ASIC1a)by hydrogen peroxide through the JNK pathway[J].中国药理学报(英文版),2021,第8期
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Yan-ping Yin,Wen-hao Shi,Ke Deng,Xiao-li Liu,Hong Li,Xiao-tong Lv,Vivian Wai Yan Lui,Chen Ding,Bo Hong,Wen-chu Lin(High Magnetic Field Laboratory,Chinese Academy of Sciences,Hefei 230031,China;University of Science and Technology of China,Hefei 230036,China;Key Laboratory of High Magnetic Field and Ion Beam Physical Biology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China;State Key Laboratory of Proteomics,Beijing Proteome Research Center,Beijing Institute of Lifeomics,National Center for Protein Sciences(The PHOENIX Center,Beijing),Beijing 102206,China;High Magnetic Field Laboratory,Chinese Academy of Sciences,Hefei 230031,China;Key Laboratory of High Magnetic Field and Ion Beam Physical Biology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China;School of Biomedical Sciences,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong,Hong Kong SAR,China;State Key Laboratory of Genetic Engineering,Human Phenome Institute,Institutes of Biomedical Sciences,School of Life Sciences,Zhongshan Hospital,Fudan University,Shanghai 200433,China;State Key Laboratory of Cell Differentiation and Regulation,College of Life Science,Henan Normal University,Xinxiang 453007,China;Academy of Medical Science,Zhengzhou University,Zhengzhou 450052,China).Combinations of proteasome inhibitors with obatoclax are effective for small cell lung cancer[J].中国药理学报(英文版),2021,第8期
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Wei-hua Wang,Tao Yuan,Mei-jia Qian,Fang-jie Yan,Liu Yang,Qiao-jun He,Bo Yang,Jin-jian Lu,Hong Zhu(Zhejiang Province Key Laboratory of Anti-cancer Drug Research,Institute of Pharmacology and Toxicology,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province,Zhejiang Provincial People's Hospital,People's Hospital of Hangzhou Medical College,Hangzhou 310014,China;State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao,China).Post-translational modification of KRAS:potential targets for cancer therapy[J].中国药理学报(英文版),2021,第8期
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Hai Zou,Sheng-qing Li(Department of Pulmonary and Critical Care Medicine,Huashan Hospital,Fudan University,Shanghai 200040,China).Pulmonary fibrosis in critically ill patients with novel coronavirus pneumonia during the convalescent stage and a proposal for early intervention[J].中国药理学报(英文版),2021,第8期
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Hang Li,Mian Jiang,Shu-ya Zhao,Shu-qin Zhang,Lu Lu,Xin He,Guo-xing Feng,Xin Wu,Sai-jun Fan(Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300192,China).Exosomes are involved in total body irradiation-induced intestinal injury in mice[J].中国药理学报(英文版),2021,第7期
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María EPrados,Adela García-Martín,Juan DUnciti-Broceta,Belén Palomares,Juan ACollado,Alberto Minassi,Marco ACalzado,Giovanni Appendino,Eduardo Muñoz(Emerald Health Biotechnology,Cordoba,Spain;Maimonides Biomedical Research Institute of Cordoba,Cordoba,Spain;Department of Cellular Biology,Physiology and Immunology,University of Cordoba,Cordoba,Spain;University Hospital Reina Sofia,Cordoba,Spain;Department of Drug Science,University of Piemonte Oriental,Novara,Italy).Betulinic acid hydroxamate prevents colonic inflammation and fibrosis in murine models of inflammatory bowel disease[J].中国药理学报(英文版),2021,第7期
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Jie Yang,Zhen-dong Li,Chang-yan Hou,Zi-yu Li,Qiang Li,Shen-yu Miao,Qing Zhang,Xiao-ying Zhang,Xiao-feng Zhu,Jian-wei Jiang(Department of Biochemistry,Basic Medical College,Jinan University,Guangzhou 510632,China;Department of General Surgery,The First Affiliated Hospital of Jinan University,Guangzhou 510632,China;School of Life Sciences,Guangzhou University,Guangzhou 510632,China;Department of Breast Surgery,The First Affiliated Hospital of Jinan University,Guangzhou 510632,China;Department of Pathology,PanYu District Central Hospital,Guangzhou 511400,China;State Key Laboratory of oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Sun Yat-sen University Cancer Center,Guangzhou 510060,China).EM-2 inhibited autophagy and promoted G2/M phase arrest and apoptosis by activating the JNK pathway in hepatocellular carcinoma cells[J].中国药理学报(英文版),2021,第7期
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Li Jiang,Xiao-bing Chen,Qian Wu,Hai-ying Zhu,Cheng-yong Du,Mei-dan Ying,Qiao-jun He,Hong Zhu,Bo Yang,Ji Cao(Institute of Pharmacology and Toxicology,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Department of Breast Surgery,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310006,China;Institute of Pharmacology and Toxicology,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Innovation Institute for Artificial Intelligence in Medicine,Zhejiang University,Hangzhou 310058,China;Cancer center of Zhejiang University,Hangzhou 310058,China).The C terminus of DJ-1 determines its homodimerization, MGO detoxification activity and suppression of ferroptosis[J].中国药理学报(英文版),2021,第7期
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