-
Guoyi Tang,Sha Li,Cheng Zhang,Haiyong Chen,Ning Wang,Yibin Feng(School of Chinese Medicine,Li Ka Shing Faculty of Medicine,the University of Hong Kong).Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Jinyi Liu1,2,Liwen Ren1,2,Sha Li1,2,Wan Li1,2,Xiangjin Zheng1,2,Yihui Yang1,2,Weiqi Fu1,2,Jie Yi3,Jinhua Wang1,2,Guanhua Du1,2(The State Key Laboratory of Bioactive Substance and Function of Natural Medicines;Key Laboratory of Drug Target Research and Drug Screen,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College;Department of Clinical Laboratory,Peking Union Medical College Hospital).The biology, function, and applications of exosomes in cancer[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Qi Lv,Yao Xing,Jian Liu,Dong Dong,Yue Liu,Hongzhi Qiao,Yinan Zhang,Lihong Hu(Jiangsu Key Laboratory for Functional Substance of Chinese Medicine,Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy,School of Pharmacy,Nanjing University of Chinese Medicine).Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Meng Li1,Ying Wang2,Mengwei Li2,Xuezhen Wu3,Sarra Setrerrahmane2,Hanmei Xu2(Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products,National Institutes for Food and Drug Control;State Key Laboratory of Natural Medicines,Ministry of Education,the Engineering Research Center of Synthetic Polypeptide Drug Discovery and Evaluation of Jiangsu Province,Department of Marine Pharmacy,China Pharmaceutical University;Affiliated Hospital of Chifeng College,Inner Mongolia Autonomous).Integrins as attractive targets for cancer therapeutics[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Wenqi Yu1,Ruyi Lin1,Xueqin He1,Xiaotong Yang1,Huilin Zhang1,Chuan Hu1,Rui Liu1,Yuan Huang1,Yi Qin2,Huile Gao1(Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University;Department of Orthopedics,Zhuhai Hospital,Jinan University,Zhuhai People's Hospital).Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Liming Lin1,2,Jiaying Chi2,Yilang Yan2,Rui Luo2,Xiaoqian Feng1,2,Yuwei Zheng2,Dongyi Xian2,Xin Li3,Guilan Quan2,Daojun Liu4,Chuanbin Wu2,Chao Lu2,Xin Pan1(School of Pharmaceutical Sciences,Sun Yat-sen University;College of Pharmacy,Jinan University;The Third Affiliated Hospital,Sun Yat-sen University;Shantou University Medical College).Membrane-disruptive peptides/peptidomimetics-based therapeutics:Promising systems to combat bacteria and cancer in the drug-resistant era[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Peng Liu1,Caifang Gao1,Hongguo Chen1,Chi Teng Vong1,Xu Wu2,Xudong Tang3,Shengpeng Wang1,Yitao Wang1(State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau;Laboratory of Molecular Pharmacology,Department of Pharmacology,School of Pharmacy,Southwest Medical University;Department of Gastroenterology,Xiyuan Hospital,China Academy of Chinese Medical Sciences).Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease:Opportunities and emerging strategies[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Xiaoyu Ning1,2,Christian Wiraja2,Wan Ting Sharon Chewa1,2,Chen Fan3,Chenjie Xu1,2,4(NTU Institute for Health Technologies,Interdisciplinary Graduate Group,Nanyang Technological University;School of Chemical and Biomedical Engineering,Nanyang Technological University;Skin Research Institute of Singapore,8A Biomedical Grove;Department of Biomedical Engineering,City University of Hong Kong).Transdermal delivery of Chinese herbal medicine extract using dissolvable microneedles for hypertrophic scar treatment[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Zhe Zhao,Fangyuan Li,Jingwen Ning,Ran Peng,Junmei Shang,Hui Liu,Meiyu Shang,Xiu-Qi Bao,Dan Zhang(State Key Laboratory of Bioactive Substrate and Function of Natural Medicine,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College).Novel compound FLZ alleviates rotenoneinduced PD mouse model by suppressing TLR4/MyD88/NF-kB pathway through microbiotaegutebrain axis[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Xiaoxia Yang,Pengfei Shang,Bingfang Yu,Qiuyang Jin,Jing Liao,Lei Wang,Jianbo Ji,Xiuli Guo(Department of Pharmacology,Key Laboratory of Chemical Biology (Ministry of Education),Drug Screening UnitPlatform,School of Pharmaceutical Sciences,Shandong University).Combination therapy with miR34a and doxorubicin synergistically inhibits Doxresistant breast cancer progression via downregulation of Snail through suppressing Notch/NF-kB and RAS/RAF/MEK/ERK signaling pathway[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Haiyan Yan1,Jing Sun2,Kun Wang3,Huiqiang Wang1,Shuo Wu1,Linlin Bao4,Weiqing He3,Dong Wang5,Airu Zhu2,Tian Zhang3,Rongmei Gao3,Biao Dong3,Jianrui Li3,Lu Yang3,Ming Zhong3,Qi Lv4,Feifei Qin4,Zhen Zhuang2,Xiaofang Huang2,Xinyi Yang3,Yuhuan Li1,Yongsheng Che3,Jiandong Jiang3(CAMS Key Laboratory of Antiviral Drug Research,Beijing Key Laboratory of Antimicrobial Agents,NHC Key Laboratory of Biotechnology of Antibiotics,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College;State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University;Institute of Medicinal Biotechnology,Chinese Academy of Medical Science;Key Laboratory of Human Disease Comparative Medicine,Chinese Ministry of Health,Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Comparative Medicine Center,Peking Union Medical College;School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University).Repurposing carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Yumiao Zhao1,Jiaxin Sun1,Yin Li2,Xiuman Zhou1,Wenjie Zhai1,Yahong Wu1,Guanyu Chen3,Shanshan Gou1,Xinghua Sui4,Wenshan Zhao1,Lu Qiu1,Yongjie Yao1,Yixuan Sun1,Chunxia Chen1,Yuanming Qi1,Yanfeng Gao1,4(School of Life Sciences,Zhengzhou University;Thoracic Surgery Department,National Cancer Center,National Clinical Research Center for Cancer,Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;School of Pharmaceutical Sciences Shenzhen,Sun Yat-sen University;School of Pharmaceutical Sciences (Shenzhen),Sun Yat-sen University).Tryptophan 2,3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3β/IL-8 signaling pathway[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Ayad A.Al-Hamashi1,2,Dongxing Chen1,Youchao Deng1,Guangping Dong1,Rong Huang1(Department of Medicinal Chemistry and Molecular Pharmacology,Center for Cancer Research,Institute for Drug Discovery,Purdue University;Department of Pharmaceutical Chemistry,College of Pharmacy,University of Baghdad,Bab-almoadham).Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Ke Ma1,2,Yuting Zhang1,2,Cui Guo1,2,Yanlong Yang1,Junjie Han1,Bo Yu1,3,Wenbing Yin1,2,Hongwei Liu1,2(State Key Laboratory of Mycology,Institute of Microbiology,Chinese Academy of Sciences;Savaid Medical School,University of Chinese Academy of Sciences;CAS Key Laboratory of Microbial Physiological and Metabolic Engineering,Institute of Microbiology,Chinese Academy of Sciences).Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Maria M.Disotuar1,Jake A.Smith1,Jinze Li1,Steve Alam1,Nai-Pin Lin1,2,Danny Hung-Chieh Chou1,2(Department of Biochemistry,School of Medicine,University of Utah,Salt Lake City;Division of Endocrinology and Diabetes,Department of Pediatrics,School of Medicine,Stanford University).Facile synthesis of insulin fusion derivatives through sortase A ligation[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Xiaojin Chen1,2,Tao Guo2,Kaikai Zhang2,3,Jiacai Chen2,4,Caifen Wang2,Xiaohong Ren2,Qin Wang1,2,Yingchao Yang2,Chongjing Liu2,Wen Tan5,Shuangying Gui1,Li Wu2,Jiwen Zhang1,2,3,4(Anhui University of Traditional Chinese Medicine;Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences;Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine;Nanjing University of Traditional Chinese Medicine;Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology).Simultaneous improvement to solubility and bioavailability of active natural compound isosteviol using cyclodextrin metal-organic frameworks[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Kailin Li1,Jieqiong You1,Qian Wu1,Wen Meng2,Qiaojun He1,3,4,Bo Yang1,3,Chengliang Zhu1,Ji Cao1,3,4(Institute of Pharmacology & Toxicology,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University;Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine;Innovation Institute for Artificial Intelligence in Medicine,Zhejiang University;Cancer Center of Zhejiang University).Cyclin-dependent kinases-based synthetic lethality:Evidence, concept, and strategy[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Jinqin Chen1,Xinhong Liu2,3,Shuo Yu1,Jia Liu1,Rongfang Chen1,Yunxiao Zhang4,Ling Jiang2,Qiuyun Dai1(Beijing Institute of Biotechnology;Key Laboratory of Magnetic Resonance in Biological System,State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,Wuhan Center for Magnetic Resonance,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences;University of Chinese Academy of Sciences;College of Life Science,Hunan Normal University).A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Mirja Harms1,Monica M.W.Habib2,Simona Nemska3,Antonella Nicolò4,Andrea Gilg1,Nico Preising5,Pandian Sokkar6,7,8,Sara Carmignanii9,Martina Raasholm1,Gilbert Weidinger1,G?nül Kizilsavas10,Manfred Wagner10,Ludger St?ndker5,Ashraf H.Abadi2,Hassan Jumaa4,Frank Kirchhoff1,Nelly Frossard3,Elsa Sanchez-Garcia6,7,Jan Münch1,5(Institute of Molecular Virology,Ulm University Medical Center;Department of Pharmaceutical Chemistry,Faculty of Pharmacy and Biotechnology,German University in Cairo;Laboratoire D'Innovation Thérapeutique,UMR7200 CNRS,Université de Strasbourg and Lab Ex MEDALIS,Faculté de Pharmacie;Institute of Immunology,Ulm University Medical Center;Core Facility Functional Peptidomics,Ulm University Medical Center;Center of Medical Biotechnology,University of Duisburg-Essen;Max-Planck-Institute for Coal Research;Faculty of Allied Health Sciences,Chettinad Hospital and Research Institute,Chettinad Academy of Research and Education Max-Planck-Institut für Molekulare Physiologie;Max Planck Institute for Polymer Research).An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Xiang Li1,2,Neelakshi Gohain2,Si Chen3,Yinghua Li4,Xiaoyuan Zhao4,5,Bo Li5,William D.Tolbert2,Wangxiao He6,Marzena Pazgier2,Honggang Hu4,Wuyuan Lu7(School of Pharmacy,Second Military Medical University;Institute of Human Virology and Department of Biochemistry and Molecular Biology,University of Maryland School of Medicine;School of Medicine,Shanghai University;Institute of Translational Medicine,Shanghai University;State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences;Department of Talent Highland,the First Affiliated Hospital of Xi'an Jiaotong University;Key Laboratory of Medical Molecular Virology (MOE,NHC,CAMS) of School of Basic Medical Sciences and Shanghai Institute of Infectious Disease and Biosecurity of School of Public Health,Fudan University).Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Mengmeng Zheng1,Chunpu Li1,2,3,Mi Zhou1,Ru Jia2,Fengyu She1,Lulu Wei1,Feng Cheng4,Qi Li2,3,Jianfeng Cai1,Yan Wang2(Department of Chemistry,University of South Florida;Department of Medical Oncology & Cancer Institute of Medicine,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine;Academy of Integrative Medicine,Shanghai University of Traditional Chinese Medicine;Department of Pharmaceutical Science,College of Pharmacy,University of South Florida).Peptidomimetic-based antibody surrogate for HER2[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Cuicui Li1,2,Ni Zhao1,2,Luyan An1,2,Zhen Dai1,2,Xiaoyi Chen1,2,Fan Yang1,2,Qidong You1,Bin Di1,2,Chi Hu3,Lili Xu1,2(Jiangsu Key Laboratory of Drug Design and Optimization,China Pharmaceutical University;Key Laboratory of Drug Quality Control and Pharmacovigilance,Ministry of Education,China Pharmaceutical University;Department of Pharmaceutical Engineering,School of Engineering,China Pharmaceutical University).Apoptosis-inducing activity of synthetic hydrocarbon-stapled peptides in H358 cancer cells expressing KRASG12C[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Yiqing Yang1,Tongke Tang2,3,Xiaolu Li4,Thomas Michel5,Liqin Ling6,7,Zhenghui Huang2,8,Maruthi Mulaka6,Yue Wu1,Hongying Gao1,Liguo Wang1,Jing Zhou7,Brigitte Meunier5,Hangjun Ke6,Lubin Jiang2,8,Yu Rao1(MOE Key Laboratory of Protein Sciences,School of Pharmaceutical Sciences,MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology,Tsinghua University;Unit of Human Parasite Molecular and Cell Biology,Key Laboratory of Molecular Virology and Immunology,Institut Pasteur of Shanghai,University of Chinese Academy of Sciences,Chinese Academy of Sciences;School of Life Science and Technology,Shanghai Tech University;Department of Biochemistry and Molecular Biology,State Key Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Peking Union Medical College;Institute for Integrative Biology of the Cell (I2BC),CEA,CNRS,Université Paris-Saclay;Center for Molecular Parasitology,Department of Microbiology and Immunology,Drexel University College of Medicine;Department of Laboratory Medicine,West China Hospital,Sichuan University;The Nanjing Unicorn Academy of Innovation,Institut Pasteur of Shanghai,Chinese Academy of Sciences).Design, synthesis, and biological evaluation of multiple targeting antimalarials[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Jianfeng Cai,Lulu Wei(Department of Chemistry,University of South Florida).Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”[J].Acta Pharmaceutica Sinica B,2021,第9期
-
Siyu He1,2,Li Wu1,Xue Li3,Hongyu Sun1,Ting Xiong1,4,Jie Liu5,Chengxi Huang1,2,Huipeng Xu1,Huimin Sun6,Weidong Chen5,Ruxandra Gref3,Jiwen Zhang1,2,4,6(Center for Drug Delivery Systems,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Institut de Sciences Mole′culaires D'Orsay,Universite′ Paris-Saclay;Key Laboratory of Modern Chinese Medicine Preparations,Ministry of Education,Jiangxi University of Traditional Chinese Medicine;School of Pharmaceutical Sciences,Anhui University of Chinese Medicine;NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients,National Institutes for Food and Drug Control).Metal-organic frameworks for advanced drug delivery[J].Acta Pharmaceutica Sinica B,2021,第8期
-
Quangang Zhu1,Zhongjian Chen1,Pijush Kumar Paul1,2,Yi Lu1,3,Wei Wu1,3,Jianping Qi1,3(Shanghai Skin Disease Hospital,Tongji University School of Medicine;Department of Pharmacy,Gono Bishwabidyalay (University);Key Laboratory of Smart Drug Delivery of MOE,School of Pharmacy,Fudan University).Oral delivery of proteins and peptides:Challenges, status quo and future perspectives[J].Acta Pharmaceutica Sinica B,2021,第8期
-
Liang Han1,Chen Jiang2(Jiangsu Key Laboratory of Neuropsychiatric Diseases Research,College of Pharmaceutical Sciences,Soochow University;Key Laboratory of Smart Drug Delivery,Ministry of Education,State Key Laboratory of Medical Neurobiology,Department of Pharmaceutics,School of Pharmacy,Fudan University).Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies[J].Acta Pharmaceutica Sinica B,2021,第8期
-
Minshan Guo,Xiaojie Sun,Jiahui Chen,Ting Cai(State Key Laboratory of Natural Medicines,Department of Pharmaceutics,School of Pharmacy,China Pharmaceutical University).Pharmaceutical cocrystals:A review of preparations, physicochemical properties and applications[J].Acta Pharmaceutica Sinica B,2021,第8期
|