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Qiong Lai,Fu-ming Liu,Wang-lin Rao,Guang-ying Yuan,Zhao-yang Fan,Lu Zhang,Fei Fu,Jun-ping Kou,Bo-yang Yu,Fang Li(Jiangsu Key Laboratory of TCM Evaluation and Translational Research,Research Center for Traceability and Standardization of TCMs,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China;Jiangsu Province Hospital of Chinese Medicine,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China).Aminoacylase-1 plays a key role in myocardial fibrosis and the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure[J].中国药理学报(英文版),2022,第8期
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Ya-jing Li,Run-ping Liu,Ming-ning Ding,Qi Zheng,Jian-zhi Wu,Xiao-yong Xue,Yi-qing Gu,Bo-ning Ma,Ya-jie Cai,Shuo Li,Sheng Lin,Lu-yong Zhang,Xiaojiaoyang Li(School of Life Sciences,Beijing University of Chinese Medicine,Beijing 100029,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China;Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100029,China;Center for Drug Screening and Pharmacodynamics Evaluation,School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China).Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles[J].中国药理学报(英文版),2022,第8期
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Bin Zhang,Zhi-yi Liu,Rui Wu,Cheng-ming Zhang,Kuan Cao,Wen-gang Shan,Zhen Liu,Ming Ji,Zi-lu Tian,Gautam Sethi,Heng-liang Shi,Ren-hao Wang(Institute of Digestive Diseases,Xuzhou Medical University,Xuzhou 221004,China;Department of General Surgery,The Affiliated Hospital of Xuzhou Medical University,Xuzhou 221004,China;Department of Pharmacology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 117600,Singapore;Institute of Digestive Diseases,Xuzhou Medical University,Xuzhou 221004,China;Department of General Surgery,The Affiliated Hospital of Xuzhou Medical University,Xuzhou 221004,China;Central Laboratory,The Affiliated Hospital of Xuzhou Medical University,Xuzhou 221004,China).Transcriptional regulator CTR9 promotes hepatocellular carcinoma progression and metastasis via increasing PEG 10 transcriptional activity[J].中国药理学报(英文版),2022,第8期
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Xiao-juan Wang,Lin Qi,Ya-fang Cheng,Xue-fei Ji,Tian-yan Chi,Peng Liu,Li-bo Zou(Department of Pharmacology,Shenyang Pharmaceutical University,Shenyang 110016,China).PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease[J].中国药理学报(英文版),2022,第8期
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Briana Hempel,Zheng-Xiong Xi(Addiction Biology Unit,Molecular Targets and Medications Discovery Branch,National Institute on Drug Abuse,Intramural Research Program,Baltimore,MD 21224,USA).Mitochondrial Clk1-iron-DAT regulation pathway:a possible new therapeutic target for methamphetamine use disorder[J].中国药理学报(英文版),2022,第8期
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Zhao Shuang,Song Tianyu,Wang Ziyu,Gao Jie,Cao Jiawei,Hu Lulu,Huang Zhengrong,Xie Liping,Ji Yong.S-nitrosylation of Hsp90 promotes cardiac hypertrophy in mice through GSK3beta signaling[J].中国药理学报,2022,第8期
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Biao Qu,Xiao-Iin Wang,De-chong Zheng,Chu-tian Mai,Zhong-qiu Liu,Hua Zhou,Ying Xie(State Key Laboratory of Quality Research in Chinese Medicines,Macau University of Science and Technology,Taipa,Macao SAR,China;Faculty of Chinese Medicines,Macau University of Science and Technology,Taipa,Macao SAR,China;State Key Laboratory of Quality Research in Chinese Medicines,Macau University of Science and Technology,Taipa,Macao SAR,China;School of Pharmacy,Macau University of Science and Technology,Taipa,Macao SAR,China;Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China,School of Chinese Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China).Novel treatment for refractory rheumatoid arthritis with total glucosides of paeony and nobiletin codelivered in a self-nanoemulsifying drug delivery system[J].中国药理学报(英文版),2022,第8期
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Teng-teng Li,Cheng Peng,Ji-qiu Wang,Zhi-jian Xu,Ming-bo Su,Jia Li,Wei-liang Zhu,Jing-ya Li(State Key Laboratory of Drug Research,the National Drug Screening Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China;CAS Key Laboratory of Receptor Research;Drug Discovery and Design Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Schoolof Pharmacy,University of Chinese Academy of Sciences,Beijing 100049,China;State Key Laboratory of Drug Research,the National Drug Screening Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China).Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain[J].中国药理学报(英文版),2022,第8期
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Da-cai Xu,Li Yang,Pei-quan Zhang,Ding Yan,Qian Xue,Qing-tian Huang,Xiao-fen Li,Ya-li Hao,Dao-lin Tang,Q.Ping Dou,Xin Chen,Jin-bao Liu(Affliated Cancer Hospital&Institute of Guangzhou Medical University,Guangzhou 510095,China;Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation,School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou 511436,China;Affliated Cancer Hospital&Institute of Guangzhou Medical University,Guangzhou 510095,China;Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation,School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou 511436,China;The Department of Physiology,School of Basic Medical Sciences,Guizhou Medical University,Guiyang 550003,China;Department of Surgery,UT Southwestern Medical Center,Dallas,TX 75390,USA;Barbara Ann Karmanos Cancer Institute and Departments of Oncology,Pharmacology&Pathology,School of Medicine,Wayne State University,Detroit,MI 48201,USA).Pharmacological characterization of a novel metal-based proteasome inhibitor Na-AuPT for cancer treatment[J].中国药理学报(英文版),2022,第8期
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Cheng Xiao,Ya-wei Ji,Yi-wen Luan,Tao Jia,Cui Yin,Chun-yi Zhou(Jiangsu Province Key Laboratory of Anesthesiology,School of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China;Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology,Xuzhou Medical University,Xuzhou 221004,China;NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs,School of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China;Jiangsu Province Key Laboratory of Anesthesiology,School of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China;Jiangsu Province Key Laboratory of Anesthesiology,School of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China;Department of Anesthesiology,Wuxi People's Hospital,Wuxi 214023,China).Differential modulation of subthalamic projection neurons by short-term and long-term electrical stimulation in physiological and parkinsonian conditions[J].中国药理学报(英文版),2022,第8期
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Jin-cheng Wang,Qi Shi,Qian Zhou,Lu-lu Zhang,Yue-ping Qiu,Da-yong Lou,Li-qin Zhou,Bo Yang,Qiao-jun He,Qin-jie Weng,Jia-jia Wang(Center for Drug Safety Evaluation and Research,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Center for Drug Safety Evaluation and Research,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Hangzhou Institute of Innovative Medicine,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Department of Pharmacy,Hangzhou Medical College,Hangzhou 310053,China;Medication Department,Zhuji People's Hospital of Zhejiang Province,Zhuji,Shaoxing 311800,China).Sapidolide A alleviates acetaminophen-induced acute liver injury by inhibiting NLRP3 inflammasome activation in macrophages[J].中国药理学报(英文版),2022,第8期
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Wei-wei Liu,Fang Wang,Can Li,Xiao-yu Song,Wuxiyar Otkur,Yu-ying Zhu,Toshihiko Hayashi,Kazunori Mizuno,Shunji Hattori,Hitomi Fujisaki,Takashi Ikejima(Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China;Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China;CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China;Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China;Department of Chemistry and Life science,School of Advanced Engineering,Kogakuin University,2665-1,Nakanomachi,Hachioji,Tokyo 192-0015,Japan;Nippi Research Institute of Biomatrix,Toride,Ibaraki 302-0017,Japan;Nippi Research Institute of Biomatrix,Toride,Ibaraki 302-0017,Japan;Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China;Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development,Shenyang 110016,China).Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway[J].中国药理学报(英文版),2022,第8期
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Hong-Long Ji,Yuling Dai,Runzhen Zhao(Department of Cellular and Molecular Biology,University of Texas at Tyler Health Science Center,Tyler,TX,USA;Texas Lung Injury Institute,University of Texas at Tyler Health Science Center,Tyler,TX,USA;Department of Epidemiology,University of Alabama at Birmingham,Birmingham,AL,USA;Department of Cellular and Molecular Biology,University of Texas at Tyler Health Science Center,Tyler,TX,USA).Fibrinolytic therapy for COVID-19:a review of case series[J].中国药理学报(英文版),2022,第8期
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Yan-ping Yin,Li-ying Ma,Guo-zhen Cao,Jing-han Hua,Xiao-tong Lv,Wen-chu Lin(High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China;University of Science and Technology of China,Hefei 230026,China;Key Laboratory of High Magnetic Field and Ion Beam Physical Biology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China;High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China;Key Laboratory of High Magnetic Field and Ion Beam Physical Biology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China).FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11[J].中国药理学报(英文版),2022,第8期
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Wen Li,Tao Shaohua,Guo Fan,Li Lingzhi,Yang Hongliu,Liang Yan,Zhang Lidan,Ma Liang,Fu Ping.Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-kappaB p65 pathway[J].中国药理学报,2022,第8期
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Zhi-ping Fu,Lu-lin Wu,Jing-yi Xue,Lan-e Zhang,Chen Li,Hong-jie You,Da-li Luo(Department of Pharmacology,School of Basic Medical Sciences,Beijing Key Laboratory of Metabolic Disturbance Related Cardiovascular Disease,Capital Medical University,Beijing 100069,China).Connexin 43 hyper-phosphorylation at serine 282 triggers apoptosis in rat cardiomyocytes via activation of mitochondrial apoptotic pathway[J].中国药理学报(英文版),2022,第8期
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Shuang Zhao,Tian-yu Song,Zi-yu Wang,Jie Gao,Jia-wei Cao,Lu-lu Hu,Zheng-rong Huang,Li-ping Xie,Yong Ji(Key Laboratory of Cardiovascular and Cerebrovascular Medicine,Nanjing Medical University,Nanjing 210029,China;Key Laboratory of Targeted Intervention of Cardiovascular Disease,Collaborative Innovation Center for Cardiovascular Disease Translational Medicine,Nanjing Medical University,Nanjing 210029,China;Department of Cardiology,The First Affiliated Hospital of Xiamen University,Xiamen 361003,China;Key Laboratory of Cardiovascular and Cerebrovascular Medicine,Nanjing Medical University,Nanjing 210029,China;Key Laboratory of Targeted Intervention of Cardiovascular Disease,Collaborative Innovation Center for Cardiovascular Disease Translational Medicine,Nanjing Medical University,Nanjing 210029,China).S-nitrosylation of Hsp90 promotes cardiac hypertrophy in mice through GSK3β signaling[J].中国药理学报(英文版),2022,第8期
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Li Wen,Shao-hua Tao,Fan Guo,Ling-zhi Li,Hong-liu Yang,Yan Liang,Li-dan Zhang,Liang Ma,Ping Fu(Kidney Research Institute,National Clinical Research Center for Geriatrics and Division of Nephrology,West China Hospital of Sichuan University,Chengdu 610041,China;Research Core Facility of West China Hospital,Chengdu 610041,China;Laboratory of Anesthesia&Critical Care Medicine,Translational Neuroscience Center,West China Hospital of Sichuan University,Chengdu 610041,China).Selective EZH2 inhibitor zldl039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway[J].中国药理学报(英文版),2022,第8期
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Zhi-ying Gao,Tian-yu Chen,Ting-ting Yu,Li-ping Zhang,Si-jie Zhao,Xiao-yang Gu,Ying Pan,Ling-dong Kong(School of Life Sciences,Nanjing University,Nanjing 210023,China;School of Life Sciences,Nanjing University,Nanjing 210023,China;Institute of Chinese Medicine,Nanjing University,Nanjing 210023,China).Cinnamaldehyde prevents intergenerational effect of paternal depression in mice via regulating GR/miR-190b/BDNF pathway[J].中国药理学报(英文版),2022,第8期
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Dong Huang,Ying-yuan Zhao,Rui-min Wang,Wei Li,Fang-yu Yuan,Xue-long Yan,Xiao Yang,Gui-hua Tang,Sheng Yin,Hui-chang Bi(Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China;Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China;NMPA Key Laboratory for Research and Evaluation of Drug Metabolism,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China).Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity[J].中国药理学报(英文版),2022,第8期
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Xuan-kun Chen,Wen-bin Zhao,Zhan Zhou,Ji Cao(Institute of Pharmacology and Toxicology,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;The Innovation Institute for Artificial Intelligence in Medicine,Zhejiang University,Hangzhou 310058,China;Institute of Pharmacology and Toxicology,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;The Innovation Institute for Artificial Intelligence in Medicine,Zhejiang University,Hangzhou 310058,China;Institute of Drug Metabolism and Pharmaceutical Analysis,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Institute of Pharmacology and Toxicology,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;The Innovation Institute for Artificial Intelligence in Medicine,Zhejiang University,Hangzhou 310058,China;Cancer Center of Zhejiang University,Hangzhou 310058,China).Tumor immunity:a novel dimension for PROTACs to conquer cancer?[J].中国药理学报(英文版),2022,第8期
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Li Dan,Guo Yingying,Cen Xianfeng,Qiu Hongliang,Chen Si,Zeng Xiaofeng,Zeng Qian,Xu Man,Tang Qizhu.Lupeol protects against cardiac hypertrophy via TLR4-PI3KAkt- NF-kappaB pathways[J].中国药理学报,2022,第8期
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Ying Dong,Bi-xi Tang,Qi Wang,Li-wei Zhou,Cong Li,Xuan Zhang,Dan-dan Sun,Xin Sun,Xue-mei Zhang,Bing Xiong,Jia Li,Hong Shi,Dan-qi Chen,Yi Zang(State Key Laboratory of Drug Research;University of Chinese Academy of Sciences;Department of Pharmacology;Department of Medicinal Chemistry;Center for Supramolecular Chemistry and Catalysis and Department of Chemistry;School of Chinese Materia Medica;School of Pharmacy;Open Studio for Druggability Research of Marine Natural Products;School of Pharmaceutical Science and Technology;Department of Anesthesiology of Shanghai Pulmonary Hospital).Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis[J].中国药理学报(英文版),2022,第7期
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Jian Dong,Kai-jia Zhang,Gao-cai Li,Xing-ren Chen,Jia-jia Lin,Jia-wei Li,Zhong-yang Lv,Zhao-zhi Deng,Jin Dai,Wangsen Cao,Qing Jiang(Division of Sports Medicine and Adult Reconstructive Surgery;Department of Orthopedics;Department of Critical Care Medicine;Center for Organ Fibrosis and Remodeling Research).CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy[J].中国药理学报(英文版),2022,第7期
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Yang Li,Bo-xue Ren,Hong-mei Li,Tao Lu,Rong Fu,Zhao-qiu Wu(State Key Laboratory of Natural Medicines;State Key Laboratory of Natural Medicines).Omeprazole suppresses aggressive cancer growth and metastasis in mice through promoting Snail degradation[J].中国药理学报(英文版),2022,第7期
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Fang-fang Cai,Huang-ru Xu,Shi-hui Yu,Ping Li,Yan-yan Lu,Jia Chen,Zhi-qian Bi,Hui-song Sun,Jian Cheng,Hong-qin Zhuang,Zi-chun Hua(The State Key Laboratory of Pharmaceutical Biotechnology;School of Biopharmacy;Institute of Neuroscience;Changzhou High-Tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories Inc.).ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway[J].中国药理学报(英文版),2022,第7期
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Qiu-ju Huang,Guo-chao Liao,Xue-rong Zhuang,Meng-lan Yang,Jing-jing Yao,Jian-hua Deng,Yan-min Zhang,Ying Wang,Xiao-xiao Qi,Dong-feng Pan,Yang Guan,Zhi-ying Huang,Feng-xue Zhang,Zhong-qiu Liu,Lin-lin Lu(Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China;School of Basic Medical Sciences;Department of Radiology and Medical Imaging;State Key Laboratory of Quality Research in Chinese Medicine/Macao Institute for Applied Research in Medicine and Health).Ras inhibitor farnesylthiosalicylic acid conjugated with IR783 dye exhibits improved tumor-targeting and altered anti-breast cancer mechanisms in mice[J].中国药理学报(英文版),2022,第7期
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Man-man Chen,Ling-hua Meng(Division of Anti-tumor Pharmacology;University of Chinese Academy of Sciences).The double faced role of xanthine oxidoreductase in cancer[J].中国药理学报(英文版),2022,第7期
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Yi-li Shen,Yan-mao Wang,Ya-xin Zhang,Shen-jie Ma,Le-he Yang,Cheng-guang Zhao,Xiao-ying Huang(Division of Pulmonary Medicine;School of Pharmaceutical Sciences).Targeting cyclin-dependent kinase 9 in cancer therapy[J].中国药理学报(英文版),2022,第7期
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Rong-Rong Ye,Shuang Jiang,Xu Xu,Yan Lu,Yu-Jun Wang,Jing-Gen Liu(School of Chemical and Environmental Engineering;CAS Key Laboratory of Receptor Research;School of Chinese Materia Medica).Dezocine as a potent analgesic:overview of its pharmacological characterization[J].中国药理学报(英文版),2022,第7期
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