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Tingting Yang1,Yuzhu Hu1,2,Junming Miao1,Jing Chen1,Jiagang Liu1,Yongzhong Cheng1,Xiang Gao1(Department of Neurosurgery and Institute of Neurosurgery,State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,West China Medical School,Sichuan University and Collaborative Innovation Center for Biotherapy;Department of Medical Oncology,State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,West China Medical School,Sichuan University and Collaborative Innovation Center for Biotherapy).A BRD4 PROTAC nanodrug for glioma therapy via the intervention of tumor cells proliferation,apoptosis and M2 macrophages polarization[J].Acta Pharmaceutica Sinica B,2022,第6期
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Yurong Lai1,Xiaoyan Chu2,Li Di3,Wei Gao2,4,Yingying Guo5,Xingrong Liu6,1,Chuang Lu7,Jialin Mao8,Hong Shen9,Huaping Tang10,Cindy Q.Xia11,Lei Zhang12,Xinxin Ding13(Drug Metabolism,Gilead Sciences Inc.;Department of Pharmacokinetics,Pharmacodynamics and Drug Metabolism,Merck & Co.,Inc.;Pharmacokinetics,Dynamics and Metabolism,Pfizer Worldwide Research and Development;Translational Medicine,EMD Serono Research & Development Institute,Inc.;Eli Lilly and Company;Drug Metabolism and Pharmacokinetics Drug Metabolism and Pharmacokinetics,Accent Therapeutics,Inc. Department of Drug Metabolism and Pharmacokinetics,Genentech,A Member of the Roche Group;Drug Metabolism and Pharmacokinetics Department,Bristol-Myers Squibb Company;Bioanalysis and Biomarkers,Glaxo Smith Kline;Department of Drug Metabolism and Pharmacokinetics,Takeda Pharmaceuticals International Co.;Office of Research and Standards,Office of Generic Drugs,CDER,FDA;Department of Pharmacology and Toxicology,College of Pharmacy,University of Arizona).Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development[J].Acta Pharmaceutica Sinica B,2022,第6期
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Jiayi Ye1,2,Bo Hou1,3,Fangmin Chen1,2,Shunan Zhang1,3,Muya Xiong2,4,Tianliang Li1,Yechun Xu2,4,5,Zhiai Xu3,Haijun Yu1,2(State Key Laboratory of Drug Research & Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;University of Chinese Academy of Sciences;School of Chemistry and Molecular Engineering,East China Normal University;CAS Key Laboratory of Receptor Research,and Drug Discovery and Design Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;School of Pharmaceutical Science and Technology,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences).Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy[J].Acta Pharmaceutica Sinica B,2022,第6期
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Ozioma Udochukwu Akakuru1,Zhoujing Zhang2,M.Zubair Iqbal1,3,Chengjie Zhu1,Yewei Zhang2,Aiguo Wu1(Cixi Institute of Biomedical Engineering,International Cooperation Base of Biomedical Materials Technology and Application,Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices,Zhejiang Engineering Research Center for Biomedical Materials,Ningbo Institute of Materials Technology and Engineering,CAS;School of Medicine,Southeast University;School of Materials Science and Engineering,Zhejiang Sci-Tech University).Chemotherapeutic nanomaterials in tumor boundary delineation:Prospects for effective tumor treatment[J].Acta Pharmaceutica Sinica B,2022,第6期
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Lichan Tu1,2,3,Xinbo Cai2,Yifeng Zhang1,2,Yuru Tong4,Jian Wang5,Ping Su5,6,Yun Lu2,Tianyuan Hu7,Yunfeng Luo2,Xiaoyi Wu2,Dan Li4,Luqi Huang5,Wei Gao1,2(Beijing Shijitan Hospital,Capital Medical University;School of Traditional Chinese Medicine,Capital Medical University;School of Medicine,Zhejiang University City College;School of Pharmaceutical Sciences,Capital Medical University;State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences;Department of Chemistry,The Scripps Research Institute;School of Pharmacy,Hangzhou Normal University).Mechanistic analysis for the origin of diverse diterpenes in Tripterygium wilfordii[J].Acta Pharmaceutica Sinica B,2022,第6期
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Menghuan Tang1,2,Kai Lin2,3,Mythili Ramachandran2,Longmeng Li2,Hongye Zou2,Huzhi Zheng1,Zhao Ma2,4,Yuanpei Li2(Key Laboratory of Luminescent and Real-Time Analytical Chemistry,Ministry of Education,College of Chemistry and Chemical Engineering,Southwest University;Department of Biochemistry and Molecular Medicine,UC Davis School of Medicine;College of Food Science and Engineering,Ocean University of China;Department of Medicinal Chemistry,Key Laboratory of Chemical Biology (MOE),School of Pharmaceutical Sciences,Cheeloo College of Medicine,Shandong University).A mitochondria-targeting lipid——small molecule hybrid nanoparticle for imaging and therapy in an orthotopic glioma model[J].Acta Pharmaceutica Sinica B,2022,第6期
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Debin Zheng1,Jingfei Liu1,Limin Xie1,Yuhan Wang1,Yinghao Ding2,Rong Peng1,Min Cui3,Ling Wang2,Yongjie Zhang3,Chunqiu Zhang1,Zhimou Yang1(Key Laboratory of Bioactive Materials,Ministry of Education,State Key Laboratory of Medicinal Chemical Biology,College of Life Sciences,Collaborative Innovation Center of Chemical Science and Engineering,National Institute of Functional Materials,Nankai University;College of Pharmacy,Nankai University;Department of Human Anatomy,Nanjing Medical University).Enzyme-instructed and mitochondria-targeting peptide self-assembly to efficiently induce immunogenic cell death[J].Acta Pharmaceutica Sinica B,2022,第6期
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Fangfang Lai1,Ming Ji1,Lei Huang1,Yunchen Wang1,Nina Xue1,Tingting Du1,Kai Dong2,Xiaoqing Yao2,Jing Jin1,Zhiqiang Feng3,Xiaoguang Chen1(Department of Pharmacology,State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Tianjin Chase Sun Pharmaceutical Co.,Ltd.;Department of Pharmacochemistry,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College).YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting PD-L1 for the treatment of human cancer[J].Acta Pharmaceutica Sinica B,2022,第6期
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Wei Wang1,Shuo Feng2,Zhuyifan Ye1,Hanlu Gao1,Jinzhong Lin2,Defang Ouyang1(State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau;State Key Laboratory of Genetic Engineering,School of Life Sciences,Zhongshan Hospital,Fudan University).Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm[J].Acta Pharmaceutica Sinica B,2022,第6期
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Jiaxing Li1,2,Xiao Wang1,2,Jiayu Ding1,2,Yasheng Zhu1,2,Wenjian Min1,2,Wenbing Kuang1,2,Kai Yuan1,2,Chengliang Sun1,2,Peng Yang1,2(State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization,China Pharmaceutical University;Department of Medicinal Chemistry,School of Pharmacy,China Pharmaceutical University).Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell[J].Acta Pharmaceutica Sinica B,2022,第6期
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Peilu Song1,2,Fan Zhao3,Dahong Li1,4,Jiqiang Qu5,Miao Yao6,Yuan Su1,Hanxun Wang1,Miaomiao Zhou6,Yujie Wang1,Yinli Gao1,Feng Li7,Dongmei Zhao1,Fengjiao Zhang6,Yu Rao2,Mingyu Xia5,Haitao Li3,Jian Wang1,Maosheng Cheng1(Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education,Shenyang Pharmaceutical University;MOE Key Laboratory of Protein Sciences,School of Pharmaceutical Sciences,MOE Key Laboratory of Bioorganic Phosphorus Chemistry Chemical Biology,Tsinghua University;MOE Key Laboratory of Protein Sciences,Beijing Advanced Innovation Center for Structural Biology,Tsinghua-Peking Joint Center for Life Sciences,School of Life Sciences and School of Medicine,Tsinghua University;School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University;School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University;Wuya College of Innovation,Shenyang Pharmaceutical University;Department of Cell Biology,Key Laboratory of Cell Biology,Ministry of Public Health,and Key Laboratory of Medical Cell Biology,Ministry of Education,China Medical University).Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells[J].Acta Pharmaceutica Sinica B,2022,第6期
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Ying Liu1,2,Yu Han3,Shizhu Chen4,Jingjie Liu2,Dajiang Wang2,Yifei Huang2(Department of Ophthalmology,Beijing Rehabilitation Hospital,Capital Medical University;Department of Ophthalmology,Chinese PLA General Hospital;College of Chemistry & Environmental Science,Chemical Biology Key Laboratory of Hebei Province,Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education,Hebei University;China Resources Pharmaceutical Group Limited).Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma[J].Acta Pharmaceutica Sinica B,2022,第6期
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Ying Wu1,Congying Pu2,Yixian Fu2,Guoqiang Dong1,Min Huang2,Chunquan Sheng1(School of Pharmacy,Second Military Medical University;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,University of Chinese Academy of Sciences).NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion[J].Acta Pharmaceutica Sinica B,2022,第6期
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Jiao Xue,Yining Zhu,Shuting Bai,Chunting He,Guangsheng Du,Yuandong Zhang,Yao Zhong,Wenfei Chen,Hairui Wang,Xun Sun(Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University).Nanoparticles with rough surface improve the therapeutic effect of photothermal immunotherapy against melanoma[J].Acta Pharmaceutica Sinica B,2022,第6期
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Shanmin Zheng1,2,Jiawei Guo2,Fangyuan Cheng2,Zhengquan Gao3,Lei Du2,Chunxiao Meng1,Shengying Li2,4,Xingwang Zhang2(School of Life Sciences,Shandong University of Technology;State Key Laboratory of Microbial Technology,Shandong University;School of Pharmacy,Binzhou Medical University;Laboratory for Marine Biology and Biotechnology,Qingdao National Laboratory for Marine Science and Technology).Cytochrome P450s in algae:Bioactive natural product biosynthesis and light-driven bioproduction[J].Acta Pharmaceutica Sinica B,2022,第6期
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Zhiran Ju1,2,Menglan Li1,Junde Xu1,Daniel C.Howell1,Zhiyun Li1,Fen-Er Chen1,3,4(Institute of Pharmaceutical Science and Technology,Zhejiang University of Technology;Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology;Engineering Center of Catalysis and Synthesis for Chiral Molecules,Fudan University;Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs).Recent development on COX-2 inhibitors as promising anti-inflammatory agents:The past 10 years[J].Acta Pharmaceutica Sinica B,2022,第6期
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Editoral Office of Acta Pharmaceutica Sinica(Editoral Office of Acta Pharmaceutica Sinica).Information for Authors[J].Acta Pharmaceutica Sinica B,2022,第6期
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Piao Luo1,2,Dandan Liu1,Qian Zhang1,Fan Yang3,4,Yin-Kwan Wong1,Fei Xia1,Junzhe Zhang1,Jiayun Chen1,Ya Tian1,Chuanbin Yang3,Lingyun Dai3,Han-Ming Shen5,Jigang Wang1,2,3,4,6(Artemisinin Research Center,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;Central People's Hospital of Zhanjiang;Department of Urology,the Second Clinical Medical College,Jinan University(Shenzhen People's Hospital);Integrated Chinese and Western Medicine Postdoctoral Research Station,Jinan University;Faculty of Health Sciences,University of Macau;Guangdong Provincial Key Laboratory of New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University).Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1[J].Acta Pharmaceutica Sinica B,2022,第5期
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Baoyi Guan1,2,Jinlin Tong1,Haiping Hao3,Zhixu Yang1,Keji Chen1,2,Hao Xu1,2,Anlu Wang1,2(Xiyuan Hospital,China Academy of Chinese Medical Sciences;National Clinical Research Center for Chinese Medicine Cardiology;State Key Laboratory of Natural Medicines,China Pharmaceutical University).Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases[J].Acta Pharmaceutica Sinica B,2022,第5期
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Chan Feng1,2,3,Yongjiang Li2,4,Bijan Emiliano Ferdows2,Dylan Neal Patel2,Jiang Ouyang2,Zhongmin Tang2,Na Kong2,Enguo Chen1,3,Wei Tao2(Department of Respiratory Medicine,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine;Center for Nanomedicine and Department of Anesthesiology,Brigham and Women's Hospital,Harvard Medical School;Cancer Center,Zhejiang University;Department of Pharmacy,the Second Xiangya Hospital of Central South University;Center for Nanomedicine and Department of Anesthesiology,Brigham and Women’s Hospital,Harvard Medical School).Emerging vaccine nanotechnology:From defense against infection to sniping cancer[J].Acta Pharmaceutica Sinica B,2022,第5期
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Yuhong Zhang1,Yanqing Ding1,Min Li1,Jing Yuan2,Youhui Yu2,Xueying Bi1,Huiqi Hong1,Jiantao Ye1,Peiqing Liu1(Department of Pharmacology and Toxicology,School of Pharmaceutical Sciences,National and Local United Engineering Lab of Druggability and New Drugs Evaluation,Sun Yat-sen University;State Key Laboratory of Oncology in Southern China,Collaborative Innovation Center for Cancer Medicine,Sun Yat-sen University Cancer Center).MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B[J].Acta Pharmaceutica Sinica B,2022,第5期
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Xuesong Li1,Ruigong Zhu1,Hong Jiang1,Quanwen Yin1,Jiaming Gu1,Jiajing Chen1,Xian Ji1,Xuan Wu1,Haiping Fu1,Hui Wang1,Xin Tang1,Yuanqing Gao1,Bingjian Wang2,Yong Ji1,3,Hongshan Chen1,3,4,2(Key Laboratory of Cardiovascular and Cerebrovascular Medicine,School of Pharmacy,Nanjing Medical University;Department of Cardiology,Huai'an First People's Hospital Affiliated with Nanjing Medical University;Key Laboratory of Targeted Intervention of Cardiovascular Disease,Collaborative Innovation Center for Cardiovascular Disease Translational Medicine,Nanjing Medical University;Department of Cardiothoracic Surgery,the Second Affiliated Hospital of Nanjing Medical University).Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis[J].Acta Pharmaceutica Sinica B,2022,第5期
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Kun Luo1,2,Wenting Huang1,2,Liansheng Qiao1,2,Xiaoling Zhang3,Di Yan4,Zhiyu Ning1,2,Chengmei Ma3,Honglei Dang3,Dong Wang4,Hongyan Guo3,Lan Xie1,2,3,Jing Cheng1,2,3,4(State Key Laboratory of Membrane Biology,School of Medicine,Tsinghua University;Medical Systems Biology Research Center,School of Medicine,Tsinghua University;National Engineering Research Center for Beijing Biochip Technology;School of Basic Medical Sciences,Chengdu University of Traditional Chinese Medicine).Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation[J].Acta Pharmaceutica Sinica B,2022,第5期
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Xiaoli Pan1,Junping Pei1,Aoxue Wang1,Wen Shuai1,Lu Feng1,Faqian Bu1,Yumeng Zhu1,Lan Zhang2,Guan Wang1,Liang Ouyang1(State Key Laboratory of Biotherapy and Cancer Center,Innovation Center of Nursing Research,Nursing Key Laboratory of Sichuan Province,National Clinical Research Center for Geriatrics,West China Hospital,and Collaborative Innovation Center of Biotherapy,Sichuan University;Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs,School of Life Science and Engineering,Southwest Jiaotong University).Development of small molecule extracellular signal-regulated kinases(ERKs) inhibitors for cancer therapy[J].Acta Pharmaceutica Sinica B,2022,第5期
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Ting Chen1,2,Bo Zhuang2,3,Yueqi Huang2,Yan Liu2,Bochuan Yuan2,Wanmei Wang2,Tianyu Yuan2,Lina Du1,2,Yiguang Jin1,2(Guangdong Pharmaceutical University;Department of Pharmaceutical Sciences,Beijing Institute of Radiation Medicine;Department of Chemical Defense,Institute of NBC Defense).Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis[J].Acta Pharmaceutica Sinica B,2022,第5期
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Dandan Shen1,2,Bo Wang1,2,Ya Gao1,2,Lijuan Zhao1,2,3,Yaping Bi1,2,Jinge Zhang1,2,Ning Wang4,Huiqin Kang1,2,Jingru Pang1,2,Ying Liu1,2,Luping Pang1,2,Zhe-Sheng Chen5,Yi-Chao Zheng1,2,3,Hong-Min Liu1,2,3(Key Laboratory of Advanced Drug Preparation Technologies,Ministry of Education of China,Collaborative Innovation Center of New Drug Research and Safety Evaluation,Zhengzhou University;Key Laboratory of Henan Province for Drug Quality and Evaluation,Institute of Drug Discovery and Development,School of Pharmaceutical Sciences,Zhengzhou University;State Key Laboratory of Esophageal Cancer Prevention & Treatment,Academy of Medical Sciences,Zhengzhou University;The School of Chinese Medicine,The University of Hong Kong;Department of Pharmaceutical Sciences,College of Pharmacy and Health Sciences,St.John's University).Detailed resume of RNA m~6A demethylases[J].Acta Pharmaceutica Sinica B,2022,第5期
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Wei Gao1,Hongxiang Hu1,Lipeng Dai1,Miao He1,Hebao Yuan1,Huixia Zhang1,Jinhui Liao1,Bo Wen1,Yan Li2,Maria Palmisano2,Mohamed Dit Mady Traore1,Simon Zhou2,Duxin Sun1(Department of Pharmaceutical Sciences,College of Pharmacy,University of Michigan;Translational Development and Clinical Pharmacology,Bristol Myers Squibb).Structure-tissue exposure/selectivity relationship(STR) correlates with clinical efficacy/safety[J].Acta Pharmaceutica Sinica B,2022,第5期
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