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Luchen Sun1,Nanfei Yang2,Bing Chen3,Yuncheng Bei4,Zisheng Kang5,Can Zhang5,Nan Zhang6,Peipei Xu3,Wei Yang7,Jia Wei4,Jiangqiong Ke1,Weijian Sun1,Xiaokun Li8,Pingping Shen1,9,10(The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University;School of Pharmaceutical Science,Wenzhou Medical University;Department of Hematology,the Affiliated Drum Tower Hospital of Nanjing University Medical School;The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing University;State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases,Center of Drug Discovery,China Pharmaceutical University;Centre of Micro/Nano Manufacturing Technology (MNMT-Dublin),School of Mechanical & Materials Engineering,University College Dublin;Department of Surgery,Division of Cancer Biology and Therapeutics,Cedars-Sinai Medical Center;Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health) & School of Pharmaceutical Science,Wenzhou Medical University;Department of Urology,Drum Tower Hospital,Medical School of Nanjing University,Institute of Urology,Nanjing University;Shenzhen Research Institute of Nanjing University).A novel mesenchymal stem cell-based regimen for acute myeloid leukemia differentiation therapy[J].Acta Pharmaceutica Sinica B,2023,第7期
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Jingwen Dong,Chenfei Zhu,Ying Huang,Quanhao Li,Jing Li,Zheng Wang,Yixin Wang,Zhanwei Zhou,Minjie Sun(NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients,State Key Laboratory of Natural Medicines,Department of Pharmaceutics,China Pharmaceutical University).Reversing the PAI-1-induced fibrotic immune exclusion of solid tumor by multivalent CXCR4 antagonistic nano-permeator[J].Acta Pharmaceutica Sinica B,2023,第7期
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Yi-Zheng Fang1,2,3,Li Jiang1,2,3,Qiaojun He2,3,4,Ji Cao1,2,3,Bo Yang1,2(Institute of Pharmacology and Toxicology,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University;The Innovation Institute for Artificial Intelligence in Medicine,Zhejiang University;Cancer Center of Zhejiang University;Center for Drug Safety Evaluation and Research of Zhejiang University).Deubiquitination complex platform:A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes[J].Acta Pharmaceutica Sinica B,2023,第7期
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Ya-Li Sang1,2,3,Christophe Pannecouque4,Erik De Clercq4,Shuai Wang1,2,Fen-Er Chen1,2,3(Department of Chemistry,Engineering Center of Catalysis and Synthesis for Chiral Molecules,Fudan University;Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs;School of Science,Harbin Institute of Technology (Shenzhen);Rega Institute for Medical Research,KU Leuven).Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability[J].Acta Pharmaceutica Sinica B,2023,第7期
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Yiqun Li,Mingrui Yang,Yanan Nan,Jiaming Wang,Sanjiao Wang,Dongxiao Cui,Jiajian Guo,Pengfei He,Wenxin Dai,Shuqi Zhou,Yue Zhang,Wenfu Ma(School of Life Science,Beijing University of Chinese Medicine).SARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor[J].Acta Pharmaceutica Sinica B,2023,第7期
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Meng Pan1,Danrong Hu1,2,Liping Yuan1,Yan Yu1,Yicong Li1,Zhiyong Qian1(State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University,Collaborative Innovation Center of Biotherapy;Rehabilitation Medicine Center and Institute of Rehabilitation Medicine,Key Laboratory of Rehabilitation Medicine in Sichuan Province,West China Hospital,Sichuan University).Newly developed gas-assisted sonodynamic therapy in cancer treatment[J].Acta Pharmaceutica Sinica B,2023,第7期
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Lin Hou1,2,3,Xueyuan Peng1,2,Ruiting Wang1,2,Yifei Wang1,2,Hong Li1,2,Huijuan Zhang1,2,3,Yun Zhang1,2,3,Zhenzhong Zhang1,2,3(School of Pharmaceutical Sciences,Zhengzhou University;Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases,Zhengzhou University;Collaborative Innovation Center of New Drug Research and Safety Evaluation,Zhengzhou University).Oral nano-formulation improves pancreatic islets dysfunction via lymphatic transport for antidiabetic treatment[J].Acta Pharmaceutica Sinica B,2023,第7期
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Zhun Lin1,Zhengyu Zou2,Zhe Pu1,Minhao Wu2,Yuanqing Zhang1(School of Pharmaceutical Sciences,Sun Yat-sen University;Zhongshan School of Medicine,Sun Yat-sen University).Application of microfluidic technologies on COVID-19 diagnosis and drug discovery[J].Acta Pharmaceutica Sinica B,2023,第7期
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Zhuang Li1,Na Liu2,Wanzhen Yang2,Jie Tu2,Yahui Huang2,Wei Wang1,3,Chunquan Sheng2(State Key Laboratory of Bioengineering Reactor,And Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science & Technology;School of Pharmacy,Second Military Medical University (Naval Medical University);Department of Pharmacology and Toxicology,College of Pharmacy,And BIO5 Institute,University of Arizona).Controlling antifungal activity with light:Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors[J].Acta Pharmaceutica Sinica B,2023,第7期
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Qiaobo Xie1,Yanyan Chu2,Wenmin Yuan3,Yanan Li4,Keqin Li1,Xinfeng Wu1,Xiaohui Liu1,Rui Xu1,Shuxiang Cui4,Xianjun Qu1(Department of Pharmacology,School of Basic Medical Sciences,Capital Medical University;Ocean University of China,School of Medicine and Pharmacy;Marine Biomedical Research Institute of Qingdao;Department of Toxicology and Sanitary Chemistry,Beijing Key Laboratory of Environmental Toxicology,School of Public Health,Capital Medical University).Activation of insulin-like growth factor-1 receptor (IGF-1R) promotes growth of colorectal cancer through triggering the MEX3A-mediated degradation of RIG-Ⅰ[J].Acta Pharmaceutica Sinica B,2023,第7期
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Zhiwen Li,Zhihao Guo,Xi Lu,Xican Ma,Xiukun Wang,Rui Zhang,Xinxin Hu,Yanxiang Wang,Jing Pang,Tianyun Fan,Yonghua Liu,Sheng Tang,Haigen Fu,Jingpu Zhang,Yinghong Li,Xuefu You,Danqing Song(Beijing Key Laboratory of Antimicrobial Agents,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College).Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs[J].Acta Pharmaceutica Sinica B,2023,第7期
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Lin Zhang1,Dongna Li1,Pengrong Yi1,Jiangwei Shi2,3,Mengqing Guo1,Qingsheng Yin1,4,Dingbin Liu5,Pengwei Zhuang1,4,Yanjun Zhang1,4,2,3(State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine;First Teaching Hospital of Tianjin University of Traditional Chinese Medicine;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion;Haihe Laboratory of Modern Chinese Medicine;State Key Laboratory of Medicinal Chemical Biology,Research Center for Analytical Sciences,and Tianjin Key Laboratory of Molecular Recognition and Biosensing,College of Chemistry,Nankai University).Peripheral origin exosomal micro RNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment[J].Acta Pharmaceutica Sinica B,2023,第7期
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Junwoo Lee1,Dongwoo Khang1,2,3,4(College of Medicine,Gachon University;Lee Gil Ya Cancer and Diabetes Institute,Gachon University;Gachon Advanced Institute for Health Science & Technology,Gachon University;Department of Physiology,College of Medicine,Gachon University).Mucosal delivery of nanovaccine strategy against COVID-19 and its variants[J].Acta Pharmaceutica Sinica B,2023,第7期
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Jingnan Zhang,Ze Zhang,Zhenlin Huang,Manlin Li,Fan Yang,Zeqi Wu,Qian Guo,Xiyu Mei,Bin Lu,Changhong Wang,Zhengtao Wang,Lili Ji(The MOE Key Laboratory for Standardization of Chinese Medicines,Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine).Isotoosendanin exerts inhibition on triple-negative breast cancer through abrogating TGF-β-induced epithelial—mesenchymal transition via directly targeting TGFβR1[J].Acta Pharmaceutica Sinica B,2023,第7期
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Liang He1,Ziwei Xu2,Xin Niu2,Rong Li1,Fanhua Wang1,Yu You2,Jingduo Gao2,Lei Zhao1,Karan M.Shah3,Jian Fan4,Mingyao Liu2,Jian Luo1(Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center),Tongji University School of Medicine;Shanghai Key Laboratory of Regulatory Biology,Institute of Biomedical Sciences and School of Life Sciences,East China Normal University;Department of Oncology and Metabolism,the Medical School,the University of Sheffield;Department of Orthopedics,Tongji Hospital,Tongji University School of Medicine).GPRC5B protects osteoarthritis by regulation of autophagy signaling[J].Acta Pharmaceutica Sinica B,2023,第7期
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Shuai Xiong1,Hui Xiao1,Meng Sun1,Yunjie Liu1,Ling Gao1,Ke Xu1,Haiying Liang1,Nan Jiang2,Yuhui Lin1,Lei Chang1,Haiyin Wu1,3,Dongya Zhu1,3,Chunxia Luo1,3(Department of Pharmacology,School of Pharmacy,Nanjing Medical University;Department of Medicinal Chemistry,School of Pharmacy,Nanjing Medical University;Collaborative Innovation Center for Cardiovascular Disease Translational Medicine,Nanjing Medical University).Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window[J].Acta Pharmaceutica Sinica B,2023,第7期
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Aihua Wu,Afeng Yang,Qinli Tong,Guoguang Wei,Sihang Zhang,Sheng Yu,Chen Zhang,Jiaojiao Xu,Wei Lu(School of Pharmacy & Minhang Hospital,Key Laboratory of Smart Drug Delivery,Ministry of Education,& State Key Laboratory of Molecular Engineering of Polymers,Fudan University).A rationally designed cancer vaccine based on NIR-II fluorescence image-guided light-triggered remote control of antigen cross-presentation and autophagy[J].Acta Pharmaceutica Sinica B,2023,第7期
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Yi Zhou1,2,Yingling Miao2,Qiudi Huang2,Wenwen Shi2,Jiacui Xie2,3,Jiachang Lin2,Pei Huang2,3,Chengfeng Yue2,4,Yuan Qin2,Xiyong Yu2,He Wang4,Linghao Qin3,Jianhai Chen1(Nanfang Hospital,Southern Medical University;Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease and the Fifth Affiliated Hospital,School of Pharmaceutical Sciences,Guangzhou Medical University;School of Pharmacy,Guangdong Pharmaceutical University;Center of Cancer Research,The Second Affiliated Hospital,Guangzhou Medical University).A redox-responsive self-assembling COA-4-arm PEG prodrug nanosystem for dual drug delivery suppresses cancer metastasis and drug resistance by downregulating hsp90 expression[J].Acta Pharmaceutica Sinica B,2023,第7期
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Xiangshi Sun1,Xiaoxuan Xu2,Jue Wang2,Xinyue Zhang3,Zitong Zhao2,Xiaochen Liu2,Guanru Wang2,Lesheng Teng4,Xia Chen1,Dangge Wang2,5,Yaping Li2,6,3(Department of Pharmacology,College of Basic Medical Sciences,Jilin University;State Key Laboratory of Drug Research & Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;School of Chinese Materia Medica,Nanjing University of Chinese Medicine;School of Life Sciences,Jilin University;Yantai Key Laboratory of Nanomedicine & Advanced Preparations,Yantai Institute of Materia Medica;Shandong Laboratory of Yantai Drug Discovery,Bohai Rim Advanced Research Institute for Drug Discovery).Acid-switchable nanoparticles induce self-adaptive aggregation for enhancing antitumor immunity of natural killer cells[J].Acta Pharmaceutica Sinica B,2023,第7期
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Mojtaba Shamsipur,Atefeh Ghavidast,Afshin Pashabadi(Department of Chemistry,Razi University).Phototriggered structures:Latest advances in biomedical applications[J].Acta Pharmaceutica Sinica B,2023,第7期
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Yanlin Luo1,2,3,Yibing Chen4,Huan Jin2,Benxin Hou,Hongsheng Li6,Xiang Li7,Lingfeng Liu2,Yuan Zhou2,Yonghua Li2,Yong Sang Song8,Quentin Liu9,Zhengzhi Zou2,10(Department of Gynecologic Oncology,the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital;MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science,Guangdong Provincial Key Laboratory of Laser Life Science,College of Biophotonics,South China Normal University;Institute of Clinical Pharmacology,School of Basic Medical Science,Academy of Medical Science,Zhengzhou University;Genetic and Prenatal Diagnosis Center,Department of Gynecology and Obstetrics,First Affiliated Hospital,Zhengzhou University;Department of General Surgery,the Third People’s Hospital of Hainan Province;Department of Breast Surgery,Affiliated Cancer Hospital & Institute of Guangzhou Medical University;Department of Pathophysiology,School of Basic Medical Sciences,Zhengzhou University;Department of Obstetrics and Gynecology,Cancer Research Institute,College of Medicine,Seoul National University;State Key Laboratory of Oncology in South China,Cancer Center,Sun Yat-sen University;Guangzhou Key Laboratory of Spectral Analysis and Functional Probes,College of Biophotonics,South China Normal University).The suppression of cervical cancer ferroptosis by macrophages:The attenuation of ALOX15 in cancer cells by macrophages-derived exosomes[J].Acta Pharmaceutica Sinica B,2023,第6期
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Yanqiong Zhang1,Xin Li1,Yulong Shi2,Tong Chen3,Zhijian Xu2,Ping Wang1,Meng Yu1,Wenjia Chen1,Bing Li1,Zhiwei Jing4,Hong Jiang1,Lu Fu1,Wenjing Gao1,Yanhua Jiang4,Xia Du5,Zipeng Gong6,Weiliang Zhu2,Hongjun Yang7,Haiyu Xu1(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;State Key Laboratory of Drug Research,Drug Discovery and Design Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;National Resource Center for Chinese Materia Medica,Chinese Academy of Chinese Medical Sciences;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences;Shaanxi Academy of Traditional Chinese Medicine;State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Provincial Key Laboratory of Pharmaceutics,Guizhou Medical University;China Academy of Chinese Medical Sciences).ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine[J].Acta Pharmaceutica Sinica B,2023,第6期
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Xin Jin1,2,3,Tingting Qiu1,Li Li1,Rilei Yu1,Xiguang Chen2,Changgui Li4,Christopher G.Proud5,Tao Jiang1(School of Medicine and Pharmacy,Ocean University of China and Laboratory for Marine Drugs and Bioproducts,Qingdao National Laboratory for Marine Science and Technology;College of Marine Life Sciences,Ocean University of China;Shandong Laboratory of Yantai Drug Discovery,Bohai Rim Advanced Research Institute for Drug Discovery;Shandong Provincial Key Laboratory of Metabolic Diseases,Qingdao Key Laboratory of Gout,Affiliated Hospital of Qingdao University Medical College,Qingdao University;Lifelong Health Theme,South Australian Health and Medical Research Institute).Pathophysiology of obesity and its associated diseases[J].Acta Pharmaceutica Sinica B,2023,第6期
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Weirong Kang1,2,3,Yuwei Liu1,2,3,Weiping Wang1,2,3(State Key Laboratory of Pharmaceutical Biotechnology,the University of Hong Kong;Department of Pharmacology and Pharmacy,Li Ka Shing Faculty of Medicine,the University of Hong Kong;Laboratory of Molecular Engineering and Nanomedicine,Dr.Li Dak-Sum Research Centre,the University of Hong Kong).Light-responsive nanomedicine for cancer immunotherapy[J].Acta Pharmaceutica Sinica B,2023,第6期
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Yanping Wang1,2,Yanfeng Gao1,Yongchun Pan1,Dongtao Zhou1,Yuta Liu1,Yi Yin1,Jingjing Yang1,Yuzhen Wang3,Yujun Song1(College of Engineering and Applied Sciences,State Key Laboratory of Analytical Chemistry for Life Science,Nanjing University;Sino-French Engineer School,Nanjing University of Science and Technology;Key Laboratory of Flexible Electronics & Institute of Advanced Materials,Jiangsu National Synergistic Innovation Center for Advanced Materials,Nanjing Tech University).Emerging trends in organ-on-a-chip systems for drug screening[J].Acta Pharmaceutica Sinica B,2023,第6期
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Chen Shi1,2,Cong Zhang1,Zhiwen Fu1,Jinmei Liu1,Yuanfeng Zhou3,Bao Cheng4,Cong Wang1,Shijun Li1,Yu Zhang1,2(Department of Pharmacy,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology;Hubei Province Clinical Research Center for Precision Medicine for Critical Illness;Department of Preclinical Translational Science,Shanghai Hansoh Biomedical Co.,Ltd.;Department of Chemistry,Shanghai Hansoh Biomedical Co.,Ltd.).Antitumor activity of aumolertinib, a third-generation EGFR tyrosine kinase inhibitor, in non-small-cell lung cancer harboring uncommon EGFR mutations[J].Acta Pharmaceutica Sinica B,2023,第6期
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Qi Zhu1,Juxian Song2,3,Jia-Yue Chen1,Zhenwei Yuan3,Liangfeng Liu3,5,6,Li-Ming Xie1,Qiwen Liao7,Richard D.Ye7,Xiu Chen1,Yepiao Yan1,Jieqiong Tan8,Chris Soon Heng Tan9,Min Li3,Jia-Hong Lu1(State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau;Medical College of Acupuncture-Moxibustion and Rehabilitation,Guangzhou University of Chinese Medicine;Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research,School of Chinese Medicine,Hong Kong Baptist University;Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research,School of Chinese Medicine,Hong Kong Baptist University;Guangdong Corporate Key Laboratory of High-end Liquid Medicine R&D,Industrialization;Limin Pharmaceutical Factory,Livzon Pharmaceutical Group Inc.;Kobilka Institute of Innovative Drug Discovery,School of Medicine,the Chinese University of Hong Kong;Center for Medical Genetics,Life Science School,Central South University;Department of Chemistry,College of Science,Southern University of Science and Technology).Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson’s disease[J].Acta Pharmaceutica Sinica B,2023,第6期
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Jianxun Zhu1,Tianyue An2,Wenlong Zha1,Ke Gao2,Ting Li2,Jiachen Zi1(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs,and NHC Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;College of Pharmacy,Jinan University).Manipulation of IME4 expression, a global regulation strategy for metabolic engineering in Saccharomyces cerevisiae[J].Acta Pharmaceutica Sinica B,2023,第6期
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Kezheng Peng1,Chenye Zeng1,Yuqi Gao1,Binliang Liu2,Liyuan Li1,Kang Xu1,Yuemiao Yin1,Ying Qiu3,Mingkui Zhang4,Fei Ma2,Zhao Wang1(The Ministry of Education Key Laboratory of Protein Science,School of Pharmaceutical Sciences,Tsinghua University;Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;School of Medicine,Tsinghua University;Department of Cardiac Surgery,First Hospital of Tsinghua University).Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling[J].Acta Pharmaceutica Sinica B,2023,第6期
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Shenghua Gao1,2,3,Letian Song1,Yusen Cheng1,Fabao Zhao1,Dongwei Kang1,2,Shu Song1,Mianling Yang1,Bing Ye1,Wei Zhao4,Yajie Tang4,Erik De Clercq5,Christophe Pannecouque5,Peng Zhan1,2,Xinyong Liu1,2(Department of Medicinal Chemistry,Key Laboratory of Chemical Biology,Ministry of Education,School of Pharmaceutical Sciences,Shandong University;China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province;Shenzhen Research Institute of Shandong University,A301 Virtual University Park in South District of Shenzhen;State Key Laboratory of Microbial Technology,Shandong University;Rega Institute for Medical Research,K.U.Leuven).Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles[J].Acta Pharmaceutica Sinica B,2023,第6期
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