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Xiaomin Wang1,2,Jun Xu1,2,Yiming Sun1,Siyuwei Cao1,Hanlin Zeng1,Nan Jin1,Matthew Shou3,Shuai Tang1,Yi Chen1,2,Min Huang1,2,4(Cancer Research Center,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Division of Diabetes,Endocrinology and Metabolism,Department of Molecular Physiology and Biophysics,Vanderbilt University Medical Center;School of Pharmaceutical Science and Technology,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences).Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer[J].Acta Pharmaceutica Sinica B,2023,第6期
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Qian Yu1,2,Chang Li2,3,Qinghui Niu4,Jigang Wang5,Zhaodi Che6,Ke Lei1,He Ren1,Boyi Ma1,Yixing Ren7,Pingping Luo6,Zhuming Fan2,Huan Zhang8,9,Zhaohui Liu3,George L.Tipoe2,Jia Xiao6,7(Tumor Immunology and Cytotherapy of Medical Research Center,and Center for GI Cancer Diagnosis and Treatment,the Affiliated Hospital of Qingdao University;Bau Institute of Medical and Health Sciences Education and School of Biomedical Sciences,LKS Faculty of Medicine,the University of Hong Kong;School of Biomedical Sciences,the Chinese University of Hong Kong;Department of Liver Center,the Affiliated Hospital of Qingdao University;Department of Pathology,the Affiliated Hospital of Qingdao University;Clinical Medicine Research Institute and Department of Metabolic and Bariatric Surgery,the First Affiliated Hospital of Jinan University;Department of General Surgery,and Institute of Hepato-Biliary-Pancreas and Intestinal Disease,Affiliated Hospital of North Sichuan Medical College;Department of Applied Biology and Chemical Technology,the Hong Kong Polytechnic University;Research Center for Chinese Medicine Innovation,the Hong Kong Polytechnic University).Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis[J].Acta Pharmaceutica Sinica B,2023,第6期
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Jing Chen1,Peng Ji1,Giri Gnawali1,Mengyang Chang2,Feng Gao1,Hang Xu1,Wei Wang1,2,3(Department of Pharmacology and Toxicology,University of Arizona;Department of Chemistry and Biochemistry,University of Arizona;BIO5 Institute,and University of Arizona Cancer Center,University of Arizona).Building bioorthogonal click-release capable artificial receptors on cancer cell surface for imaging, drug targeting and delivery[J].Acta Pharmaceutica Sinica B,2023,第6期
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Shenghua Gao1,2,3,Letian Song1,Yusen Cheng1,Fabao Zhao1,Dongwei Kang1,2,Shu Song1,Mianling Yang1,Bing Ye1,Wei Zhao4,Yajie Tang4,Erik De Clercq5,Christophe Pannecouque5,Peng Zhan1,2,Xinyong Liu1,2(Department of Medicinal Chemistry,Key Laboratory of Chemical Biology,Ministry of Education,School of Pharmaceutical Sciences,Shandong University;China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province;Shenzhen Research Institute of Shandong University,A301 Virtual University Park in South District of Shenzhen;State Key Laboratory of Microbial Technology,Shandong University;Rega Institute for Medical Research,K.U.Leuven).Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles[J].Acta Pharmaceutica Sinica B,2023,第6期
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Lijuan Ma1,Boyi Li2,Jinchen Ma2,Chunyuan Wu3,Nan Li1,4,Kailin Zhou5,Yun Yan2,Mingshuang Li1,Xiaoyan Hu1,Hao Yan1,Qi Wang2,Yanfei Zheng2,Zhisheng Wu1,4(Beijing University of Chinese Medicine,School of Chinese Materia Medica;Beijing University of Chinese Medicine,School of Traditional Chinese Medicine;Shanghai New Asiatic Pharmaceuticals Hanjiang Co.,Ltd.;Engineering Research Center of Ministry of Education for Traditional Chinese Medicine Pharmaceutical and New Drug Development;Beijing University of Chinese Medicine,School of Humanities).Novel discovery of schisandrin A regulating the interplay of autophagy and apoptosis in oligoasthenospermia by targeting SCF/c-kit and TRPV1 via biosensors[J].Acta Pharmaceutica Sinica B,2023,第6期
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Gaona Shi1,Yu Zhou1,Wenshuai Liu2,Chengjuan Chen1,Yazi Wei1,Xinlong Yan3,Lei Wu1,Weiwei Wang2,Lan Sun1,Tiantai Zhang1(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College;Tianjin Key Laboratory of Biomaterial Research,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences & Peking Union Medical College;Faculty of Environmental and Life Sciences,Beijing University of Technology).Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A2A/2B receptors in tolerogenic dendritic cells[J].Acta Pharmaceutica Sinica B,2023,第6期
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Jianxun Zhu1,Tianyue An2,Wenlong Zha1,Ke Gao2,Ting Li2,Jiachen Zi1(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs,and NHC Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;College of Pharmacy,Jinan University).Manipulation of IME4 expression, a global regulation strategy for metabolic engineering in Saccharomyces cerevisiae[J].Acta Pharmaceutica Sinica B,2023,第6期
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Jianping Ye(Metabolic Disease Research Center,Zhengzhou University Affiliated Zhengzhou Central Hospital;Center for Advanced Medicine,College of Medicine,Zhengzhou University;Research Center of Basic Medicine,Academy of Medical Sciences,Zhengzhou University).Commentary:Inhibitors of mitochondrial respiratory chain in the treatment of type 2 diabetes[J].Acta Pharmaceutica Sinica B,2023,第6期
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Kezheng Peng1,Chenye Zeng1,Yuqi Gao1,Binliang Liu2,Liyuan Li1,Kang Xu1,Yuemiao Yin1,Ying Qiu3,Mingkui Zhang4,Fei Ma2,Zhao Wang1(The Ministry of Education Key Laboratory of Protein Science,School of Pharmaceutical Sciences,Tsinghua University;Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;School of Medicine,Tsinghua University;Department of Cardiac Surgery,First Hospital of Tsinghua University).Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling[J].Acta Pharmaceutica Sinica B,2023,第6期
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Jiahui He1,Yuyue Zhang1,Xinge Yu1,2,Chenjie Xu1(Department of Biomedical Engineering,City University of Hong Kong;Hong Kong Centre for Cerebro-Cardiovascular Health Engineering).Wearable patches for transdermal drug delivery[J].Acta Pharmaceutica Sinica B,2023,第6期
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Guangsheng Du,Ming Qin,Xun Sun(Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University).Recent progress in application of nanovaccines for enhancing mucosal immune responses[J].Acta Pharmaceutica Sinica B,2023,第6期
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Weirong Kang1,2,3,Yuwei Liu1,2,3,Weiping Wang1,2,3(State Key Laboratory of Pharmaceutical Biotechnology,the University of Hong Kong;Department of Pharmacology and Pharmacy,Li Ka Shing Faculty of Medicine,the University of Hong Kong;Laboratory of Molecular Engineering and Nanomedicine,Dr.Li Dak-Sum Research Centre,the University of Hong Kong).Light-responsive nanomedicine for cancer immunotherapy[J].Acta Pharmaceutica Sinica B,2023,第6期
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Tao Liang1,2,Fengli Wang3,Reham M.Elhassan2,Yongmei Cheng1,Xiaolei Tang3,4,Wengang Chen1,Hao Fang2,Xuben Hou2(Department of Pharmacy,the Second Hospital Affiliated Wannan Medical College;Department of Medicinal Chemistry and Key Laboratory of Chemical Biology(Ministry of Education),School of Pharmaceutical Sciences,Cheeloo College of Medicine,Shandong University;Department of Science and Education,Translational Medicine Center & Vascular Disease Research Center,the Second Hospital Affiliated Wannan Medical College;Clinical Pathogens Detection Engineering Center of Wuhu).Targeting histone deacetylases for cancer therapy:Trends and challenges[J].Acta Pharmaceutica Sinica B,2023,第6期
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Yaochen Xie1,Qian Zhou2,Qiaojun He1,Xiaoyi Wang,Jincheng Wang1(Center for Drug Safety Evaluation and Research,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University;Department of Pharmacy,Hangzhou Medical College;Department of Nephrology,the First Affiliated Hospital of Huzhou Teachers College,the First People’s Hospital of Huzhou).Opportunities and challenges of incretin-based hypoglycemic agents treating type 2 diabetes mellitus from the perspective of physiological disposition[J].Acta Pharmaceutica Sinica B,2023,第6期
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Lingling Zhu1,Xianzhe Yu,Ting Cao3,Hanyu Deng1,Xiaojun Tang1,Qing Lin1,Qinghua Zhou1(Lung Cancer Center/Lung Cancer Institute,West China Hospital & West China School of Pharmacy,Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan University;Department of Gastrointestinal Surgery,Chengdu Second People’s Hospital;Laboratory of Infectious Diseases and Vaccine,West China Hospital,Sichuan University).Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis[J].Acta Pharmaceutica Sinica B,2023,第6期
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Pengyun Li1,2,Changkai Jia1,2,Zhiya Fan3,Xiaotong Hu1,Wenjuan Zhang1,Ke Liu2,Shiyang Sun1,Haoxin Guo4,Ning Yang1,Maoxiang Zhu4,Xiaomei Zhuang2,Junhai Xiao1,2,Zhibing Zheng1,2,Song Li1,2(National Engineering Research Center for Strategic Drugs,Beijing Institute of Pharmacology and Toxicology Institution;State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Institute of Pharmacology and Toxicology;National Center for Protein Sciences(Beijing),Beijing Institute of Lifeomics,State Key Laboratory of Proteomics,Beijing Proteome Research Center;Beijing Key Laboratory for Radiobiology,Beijing Institute of Radiation Medicine).Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations[J].Acta Pharmaceutica Sinica B,2023,第6期
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Qi Zhu1,Juxian Song2,3,Jia-Yue Chen1,Zhenwei Yuan3,Liangfeng Liu3,5,6,Li-Ming Xie1,Qiwen Liao7,Richard D.Ye7,Xiu Chen1,Yepiao Yan1,Jieqiong Tan8,Chris Soon Heng Tan9,Min Li3,Jia-Hong Lu1(State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau;Medical College of Acupuncture-Moxibustion and Rehabilitation,Guangzhou University of Chinese Medicine;Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research,School of Chinese Medicine,Hong Kong Baptist University;Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research,School of Chinese Medicine,Hong Kong Baptist University;Guangdong Corporate Key Laboratory of High-end Liquid Medicine R&D,Industrialization;Limin Pharmaceutical Factory,Livzon Pharmaceutical Group Inc.;Kobilka Institute of Innovative Drug Discovery,School of Medicine,the Chinese University of Hong Kong;Center for Medical Genetics,Life Science School,Central South University;Department of Chemistry,College of Science,Southern University of Science and Technology).Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson’s disease[J].Acta Pharmaceutica Sinica B,2023,第6期
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Wenxin Zhang1,Xiaohui Pan1,Yanjun Xu2,Hongjie Guo1,Mingming Zheng1,Xi Chen1,Honghai Wu1,Fengming Luan3,Qiaojun He1,4,5,Ling Ding1,Bo Yang1,4(Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,Institute of Pharmacology and Toxicology,College of Pharmaceutical Sciences,Zhejiang University;Department of Medical Thoracic Oncology,the Cancer Hospital of University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),Chinese Academy of Sciences;Department of Gastrointestinal Surgery,Second Affiliated Hospital of Zhejiang University,School of Medicine;The Innovation Institute for Artificial Intelligence in Medicine,Zhejiang University;Cancer Center of Zhejiang University).Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA[J].Acta Pharmaceutica Sinica B,2023,第6期
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Nan Ru1,Wan-Yang Sun1,Hua-Jun Wang1,Yan-Ping Wu1,Xiao-Fei Zheng1,Rong-Rong He1,2(The First Affiliated Hospital/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE)/Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,Jinan University;State Key Laboratory of Quality Research in Chinese Medicine,Macau University of Science and Technology).Commentary:A nearly forgotten class of anti-inflammatory lipid molecules in central nervous system[J].Acta Pharmaceutica Sinica B,2023,第6期
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Bingwei Wang1,Yan Ma1,Sheng Li2,Hang Yao2,Mingna Gu1,Ying Liu1,You Xue1,Jianhua Ding2,Chunmei Ma2,Shuo Yang2,Gang Hu1,2(School of Medicine & Holistic Integrative Medicine,Nanjing University of Chinese Medicine;School of Basic Medical Sciences,Nanjing Medical University).GSDMD in peripheral myeloid cells regulates microglial immune training and neuroinflammation in Parkinson’s disease[J].Acta Pharmaceutica Sinica B,2023,第6期
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Yue Chen1,Jianing Song2,Yihang Cui2,Liyun Zhou2(Dongzhimen Hospital,Beijing University of Chinese Medicine;Pharmcube (Beijing) Co.,Ltd.).Five trends of China’s pharmaceutical industry in 2022[J].Acta Pharmaceutica Sinica B,2023,第6期
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Wei He1,2,Alejandro Sosnik3,Chenjie Xu4(School of Pharmacy,China Pharmaceutical University;Shanghai Skin Disease Hospital,Tongji University School of Medicine;Laboratory of Pharmaceutical Nanomaterials Science,Department of Materials Science and Engineering,Technion-Israel Institute of Technology;Department of Biomedical Engineering,City University of Hong Kong).Editorial of Special Column on Delivery Nanotechnologies to Modulate the Immune System and Combat Inflammation and Infection[J].Acta Pharmaceutica Sinica B,2023,第6期
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Ruifang Han,Yu Xiao,Qianqian Bai,Chung Hang Jonathan Choi(Department of Biomedical Engineering,the Chinese University of Hong Kong).Self-therapeutic metal-based nanoparticles for treating inflammatory diseases[J].Acta Pharmaceutica Sinica B,2023,第5期
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Wei Wei,Qingxuan Zeng,Yan Wang,Xixi Guo,Tianyun Fan,Yinghong Li,Hongbin Deng,Liping Zhao,Xintong Zhang,Yonghua Liu,Yulong Shi,Jingyang Zhu,Xican Ma,Yanxiang Wang,Jiandong Jiang,Danqing Song(Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College).Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects[J].Acta Pharmaceutica Sinica B,2023,第5期
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Chuanfeng Tang1,Qiaona Wang1,Jingyan Shen1,Congying Wang1,Hong Ding1,Shiyu Wen1,Fan Yang1,Ruiqing Jiao1,Xingxin Wu1,Jianmei Li1,Lingdong Kong1,2(State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University;State Key Laboratory of Natural Medicines,China Pharmaceutical University).Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression[J].Acta Pharmaceutica Sinica B,2023,第5期
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Jie Chen,Xiaohong Wei,Qian Zhang,Yuzhuo Wu,Guiyang Xia,Huan Xia,Lingyan Wang,Hongcai Shang,Sheng Lin(Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine).The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms[J].Acta Pharmaceutica Sinica B,2023,第5期
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Yun Teng,Yixue Huang,Hao Yu,Cenhao Wu,Qi Yan,Yingjie Wang,Ming Yang,Haifeng Xie,Tianyi Wu,Huilin Yang,Jun Zou(Department of Orthopaedic Surgery,the First Affiliated Hospital of Soochow University).Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling[J].Acta Pharmaceutica Sinica B,2023,第5期
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Damijan Knez1,Daniel Diez-Iriepa2,3,Mourad Chioua2,3,Andrea Gottinger4,Milica Denic5,Fabien Chantegreil5,Florian Nachon5,Xavier Brazzolotto5,Anna Skrzypczak-Wiercioch6,An?e Meden1,Anja Pi?lar1,Janko Kos1,Simon ?akelj1,Jure Stojan7,Kinga Sa?at8,Julia Serrano9,Ana Patricia Fernández9,Aitana Sánchez-García10,Ricardo Martínez-Murillo9,Claudia Binda4,Francisco López-Mu?oz11,Stanislav Gobec1,José Marco-Contelles2(University of Ljubljana,Faculty of Pharmacy;Laboratory of Medicinal Chemistry(Institute of Organic Chemistry,CSIC);Departamento de Química Orgánicay Química Inorgánica;Department of Biology and Biotechnology,University of Pavia;Département de Toxicologie et Risques Chimiques,Institut de Recherche Biomédicale des Armées;Department of Animal Anatomy and Preclinical Sciences,University Centre of Veterinary Medicine JU-UA,University of Agriculture in Krakow;Institute of Biochemistry,Faculty of Medicine,University of Ljubljana;Department of Pharmacodynamics,Chair of Pharmacodynamics,Faculty of Pharmacy,Jagiellonian University Medical College;Department of Translational Neurobiology,Neurovascular Research Group,Cajal Institute(CSIC);Biotechnology and Vegetal Biology Department,Escuela Técnica Superior de Ingeniería Agronómica,Alimentaria y de Biosistemas,Universidad Politécnica de Madrid;Faculty of Health,Camilo José Cela University of Madrid(UCJC),Neuropsychopharmacology Unit,"Hospital 12 de Octubre" Research Institute).8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases[J].Acta Pharmaceutica Sinica B,2023,第5期
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Bin Tu1,2,Yanrong Gao1,2,Xinran An1,3,Huiyuan Wang1,Yongzhuo Huang1,2,4,5,6(State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;University of Chinese Academy of Sciences;University of Michigan College of Pharmacy;Zhongshan Institute for Drug Discovery,SIMM,CAS;NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients;Taizhou University,School of Advanced Study,Institute of Natural Medicine and Health Product).Localized delivery of nanomedicine and antibodies for combating COVID-19[J].Acta Pharmaceutica Sinica B,2023,第5期
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