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Yub Raj Neupane1,2,Harish K.Handral3,Syed Abdullah Alkaff4,Wei Heng Chng1,5,Gopalakrishnan Venkatesan1,6,Chenyuan Huang7,8,9,Choon Keong Lee1,Jiong-Wei Wang7,8,9,10,Gopu Sriram11,Rhonnie Austria Dienzo12,Wen Feng Lu3,Yusuf Ali12,13,Bertrand Czarny4,12,Giorgia Pastorin1,5,14(Department of Pharmacy,National University of Singapore;Department of Pharmaceutical Sciences and Experimental Therapeutics,the University of Iowa College of Pharmacy;Department of Mechanical Engineering,National University of Singapore;School of Materials Science and Engineering,Nanyang Technological University;Integrative Sciences and Engineering Programme,NUS Graduate School,National University of Singapore;Antimicrobial Resistance Interdisciplinary Research Group(AMR-IRG),Singapore-MIT Alliance for Research and Technology;Department of Surgery,National University of Singapore;Cardiovascular Research Institute,National University Heart Centre;Nanomedicine Translational Research Programme,Centre for Nano Medicine,Yong Loo Lin School of Medicine,National University of Singapore;Department of Physiology,National University of Singapore;Faculty of Dentistry,National University of Singapore;Lee Kong Chian School of Medicine,Nanyang Technological University;Singapore Eye Research Institute(SERI),Singapore General Hospital;NUSNNI-Nano Core,National University of Singapore).Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing[J].Acta Pharmaceutica Sinica B,2023,第5期
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Yonghyun Choi1,Wooic Son2,3,Youngpin Han2,3,Jayoung Chae1,Chul-Su Yang2,3,Jonghoon Choi1(School of Integrative Engineering,Chung-Ang University;Department of Molecular & Life Science,Hanyang University;Center for Bionano Intelligence Education and Research,Hanyang University).Glycan targeting nanoparticle for photodynamic immunotherapy of melanoma[J].Acta Pharmaceutica Sinica B,2023,第5期
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Yunfei Yin1,Mingyue Tan1,Lianhua Han1,Lei Zhang1,Yue Zhang1,Jun Zhang1,Wanqian Pan1,Jiaxiang Bai1,2,3,Tingbo Jiang1,Hongxia Li1(Department of Cardiology,the First Affiliated Hospital of Soochow University;Department of Orthopedics,the First Affiliated Hospital of Soochow University;Department of Orthopedics,the First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China).The hippo kinases MST1/2 in cardiovascular and metabolic diseases:A promising therapeutic target option for pharmacotherapy[J].Acta Pharmaceutica Sinica B,2023,第5期
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Boya Chen1,Haiying Zhu1,Bo Yang1,2,Ji Cao1,2,3(Institute of Pharmacology and Toxicology,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University;The Innovation Institute for Artificial Intelligence in Medicine,Zhejiang University;Cancer Center of Zhejiang University).The dichotomous role of immunoproteasome in cancer:Friend or foe?[J].Acta Pharmaceutica Sinica B,2023,第5期
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Shameer M.Kondengadan,Shubham Bansal,Ce Yang,Dongning Liu,Zach Fultz,Binghe Wang(Department of Chemistry and Center for Diagnostics and Therapeutics,Georgia State University).Click chemistry and drug delivery:A bird’s-eye view[J].Acta Pharmaceutica Sinica B,2023,第5期
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Hongjuan Zhang1,Ying Chen1,Yu Zhang1,Luyao Qiao1,Xiangyin Chi1,Yanxing Han1,Yuan Lin1,Shuyi Si2,Jiandong Jiang1,2(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College).Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe[J].Acta Pharmaceutica Sinica B,2023,第5期
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Kan Xing Wu1,Thinesshwary Yogarajah2,3,Marcus Wing Choy Loe2,Parveen Kaur2,Regina Ching Hua Lee2,Chee Keng Mok4,Yi Hao Wong4,Patchara Phuektes5,Li Sze Yeo2,Vincent T.K.Chow2,3,Yong Wah Tan6,Justin Jang Hann Chu2,5,6,4(Lee Kong Chian School of Medicine,Nanyang Technological University;Department of Microbiology and Immunology,Yong Loo Lin School of Medicine,National University Health System,National University of Singapore;Infectious Disease Programme,Yong Loo Lin School of Medicine,National University of Singapore;NUSMed Biosafety Level 3 Core Facility,Yong Loo Lin School of Medicine,National University of Singapore;Department of Pathobiology,Faculty of Veterinary Medicine,Khonkaen University;Institute of Molecular and Cell Biology,Agency for Science,Technology and Research(A~*STAR)).The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses[J].Acta Pharmaceutica Sinica B,2023,第5期
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Wen Zhu1,Yang Wang1,Liangyin Lv1,Hui Wang1,Wenqiang Shi1,Zexin Liu1,Mingzhe Zhou2,Jianwei Zhu1,Huili Lu1(Engineering Research Center of Cell and Therapeutic Antibody,Ministry of Education,School of Pharmacy,Shanghai Jiao Tong University;State Key Laboratory of Genetic Engineering,School of Life Science,Fudan University).Universal chimeric Fcγ receptor T cells with appropriate affinity for IgG1 antibody exhibit optimal antitumor efficacy[J].Acta Pharmaceutica Sinica B,2023,第5期
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Jinmiao Lu,Hao Liu2,Qingtong Zhou3,4,Ming-Wei Wang3,4,Zhiping Li(Department of Pharmacy,Children’s Hospital of Fudan University,National Children’s Medical Center;School of Medicine,Ningbo University;Research Center for Deepsea Bioresources;Department of Pharmacology,School of Basic Medical Sciences,Fudan University).A potentially serious adverse effect of GLP-1 receptor agonists[J].Acta Pharmaceutica Sinica B,2023,第5期
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Huiyang Wang,Yueyang Liu,Zhenkun Guo,Minghui Cui,Peng Pang,Jingyu Yang,Chunfu Wu(Department of Pharmacology,Shenyang Pharmaceutical University).Enhancement of oligodendrocyte autophagy alleviates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion in rats[J].Acta Pharmaceutica Sinica B,2023,第5期
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Zhihui Han1,Xiang Gao2,Yuanjie Wang1,Shuning Cheng1,Xiaoyan Zhong3,Yong Xu4,Xiaozhong Zhou2,Zengli Zhang3,Zhuang Liu1,Liang Cheng1(Institute of Functional Nano & Soft Materials(FUNSOM),Collaborative Innovation Center of Suzhou Nano Science and Technology,Soochow University;Department of Orthopedics,The Second Affiliated Hospital of Soochow University;Department of Environmental Health,School of Public Health,Soochow University;School of Materials and Energy,Guangdong University of Technology).Ultrasmall iron-quercetin metal natural product nanocomplex with antioxidant and macrophage regulation in rheumatoid arthritis[J].Acta Pharmaceutica Sinica B,2023,第4期
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Jiaxuan He1,Qiao Duan1,2,Chunyan Ran1,Ting Fu1,3,Yuan Liu1,Weihong Tan1,3,2(The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),The Key Laboratory of Zhejiang Province for Aptamers and Theranostics,Hangzhou Institute of Medicine(HIM),Chinese Academy of Sciences;Institute of Molecular Medicine(IMM),Renji Hospital,Shanghai Jiao Tong University School of Medicine,and College of Chemistry and Chemical Engineering,Shanghai Jiao Tong University;Molecular Science and Biomedicine Laboratory(MBL),State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,College of Biology,Aptamer Engineering Center of Hunan Province,Hunan University).Recent progress of aptamer-drug conjugates in cancer therapy[J].Acta Pharmaceutica Sinica B,2023,第4期
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Libin Pan,Hang Yu,Jie Fu,Jiachun Hu,Hui Xu,Zhengwei Zhang,Mengmeng Bu,Xinyu Yang,Haojian Zhang,Jinyue Lu,Jiandong Jiang,Yan Wang(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences/Peking Union Medical College).Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota[J].Acta Pharmaceutica Sinica B,2023,第4期
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Yau-tuen Chan1,Hor-yue Tan1,2,Yuanjun Lu1,Cheng Zhang1,Chien-shan Cheng1,3,Junyu Wu1,Ning Wang1,Yibin Feng1(School of Chinese Medicine,the University of Hong Kong;Centre for Chinese Herbal Medicine Drug Development,School of Chinese Medicine,Hong Kong Baptist University;Department of Traditional Chinese Medicine,Shanghai Jiaotong University,School of Medicine Affiliated Ruijin Hospital).Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis[J].Acta Pharmaceutica Sinica B,2023,第4期
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Sili Zheng1,Zhiyong Li1,Jie Song1,Pin Wang1,Jian Xu2,Wenjun Hu1,Yi Shi3,Qi Qi1,Zhuwei Miao1,Yunfeng Guan1,Chaoyu Miao1(Department of Pharmacology,Second Military Medical University/Naval Medical University;Changhai Hospital,Second Military Medical University/Naval Medical University;Zhongshan Hospital,Fudan University).Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis[J].Acta Pharmaceutica Sinica B,2023,第4期
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Xiaoqing Liu,Shuang Liang,Xiao Sang,Lili Chang,Shunli Fu,Han Yang,Huizhen Yang,Yongjun Liu,Na Zhang(Department of Pharmaceutics,Key Laboratory of Chemical Biology(Ministry of Education),NMPA Key Laboratory for Technology Research and Evaluation of Drug Products,School of Pharmaceutical Sciences,Cheeloo College of Medicine,Shandong University).On-demand integrated nano-engager converting cold tumors to hot via increased DNA damage and dual immune checkpoint inhibition[J].Acta Pharmaceutica Sinica B,2023,第4期
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Zhimei Xing1,2,Han Gao1,3,Dan Wang1,2,Ye Shang1,2,Tenukeguli Tuliebieke1,2,Jibao Jiang4,Chunxiao Li1,2,Hong Wang1,Zhenguo Li5,Lifu Jia6,Yongsheng Wu5,Dandan Wang5,Wenzhi Yang1,2,Yanxu Chang1,2,Xiaoying Zhang1,2,Liuwei Xu1,2,Chao Jiang7,Luqi Huang7,Xiaoxuan Tian1,2(State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine;Haihe Laboratory of Modern Chinese Medicine;Jiangsu Key Laboratory for Biodiversity and Biotechnology,College of Life Sciences,Nanjing Normal University;School of Agriculture and Biology,Shanghai Jiao Tong University;Mudanjiang YouBo Pharmaceutical Co.Ltd.;Guizhou Ruihe Pharmaceutical Co.Ltd.;State Key Laboratory of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences).A novel biological sources consistency evaluation method reveals high level of biodiversity within wild natural medicine:A case study of Amynthas earthworms as "Guang Dilong"[J].Acta Pharmaceutica Sinica B,2023,第4期
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Yuyu Liu,Xinnan Li,Songyang Sui,Jingshu Tang,Dawei Chen,Yuying Kang,Kebo Xie,Jimei Liu,Jiaqi Lan,Lei Wu,Ridao Chen,Ying Peng,Jungui Dai(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs,and NHC Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College).Structural diversification of bioactive bibenzyls through modular co-culture leading to the discovery of a novel neuroprotective agent[J].Acta Pharmaceutica Sinica B,2023,第4期
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Yichen Zhong1,2,Shi Du1,2,Yizhou Dong1,3,2(Division of Pharmaceutics & Pharmacology,College of Pharmacy,The Ohio State University;Icahn Genomics Institute,Precision Immunology Institute,Department of Oncological Sciences,Tisch Cancer Institute,Friedman Brain Institute,Icahn School of Medicine at Mount Sinai;Department of Radiation Oncology,Department of Biomedical Engineering,Center for Clinical and Translational Science,Comprehensive Cancer Center,Dorothy M. Davis Heart & Lung Research Institute,Center for Cancer Engineering,Center for Cancer Metabolism,Pelotonia Institute for Immune-Oncology,The Ohio State University).mRNA delivery in cancer immunotherapy[J].Acta Pharmaceutica Sinica B,2023,第4期
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Yan Shi1,Candy Lee2,Peng Sang1,Zaid Amso2,David Huang2,Weixia Zhong2,Meng Gu1,Lulu Wei1,Van T.B.Nguyen-Tran2,Jingyao Zhang1,Weijun Shen2,Jianfeng Cai1(Department of Chemistry,University of South Florida;Calibr at Scripps Research).α/Sulfono-γ-AA peptide hybrids agonist of GLP-1R with prolonged action both in vitro and in vivo[J].Acta Pharmaceutica Sinica B,2023,第4期
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Yiwei Zhu,Lin Lei,Xinghui Wang,Linfang Chen,Wei Li,Jinxia Li,Chenchen Zhao,Xiliang Du,Yuxiang Song,Wenwen Gao,Guowen Liu,Xinwei Li(State Key Laboratory for Zoonotic Diseases,Key Laboratory of Zoonosis Research,Ministry of Education,College of Veterinary Medicine,Jilin University).The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation[J].Acta Pharmaceutica Sinica B,2023,第4期
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Xuan Li1,Shicheng Fan1,2,Chenghui Cai1,Yue Gao1,Xinhui Wang3,Yifei Zhang1,Hangfei Liang1,Huilin Li1,Jie Yang1,Min Huang1,Huichang Bi1,2(Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University;NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University;School of Pharmaceutical Sciences(Shenzhen),Sun Yat-sen University).YAP regulates the liver size during the fasting-refeeding transition in mice[J].Acta Pharmaceutica Sinica B,2023,第4期
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Yixiang Xu1,Chao Zhang1,Kai Jiang2,Xinchun Yang3,Feng Chen2,Zhiyang Cheng2,Jinlong Zhao3,Jiaxing Cheng3,Xiaokang Li1,Xin Chen1,Luoyifan Zhou1,Hao Duan1,Yunyuan Huang4,Yaozu Xiang2,Jian Li1,5,6,7(State Key Laboratory of Bioreactor Engineering,Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,Frontiers Science Center for Materiobiology and Dynamic Chemistry,Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology;Shanghai East Hospital,School of Life Sciences and Technology,Tongji University;East China University of Science and Technology-Tengbai Pharmaceutical Innovative Drugs Joint Research Institute,Zhuhai Tengbai Pharmaceutical Co.,Ltd.;Hubei Key Laboratory of Genetic Regulation and Integrative Biology,School of Life Sciences,Central China Normal University;Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yunnan,College of Pharmacy,Dali University;Clinical Medicine Scientific and Technical Innovation Center,Shanghai Tenth People's Hospital,Tongji University School of Medicine;Key Laboratory of Tropical Biological Resources of Ministry of Education,College of Pharmacy,Hainan University).Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria[J].Acta Pharmaceutica Sinica B,2023,第4期
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Yongxi Liang1,Delin Min1,Hulin Fan1,Kunlin Liu1,Juchuanli Tu2,Xueyan He2,Bingjie Liu2,Lu Zhou1,Suling Liu2,Xun Sun1,3(School of Pharmacy,Fudan University;Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences,State Key Laboratory of Genetic Engineering,Fudan University;The Institutes of Integrative Medicine of Fudan University).Discovery of a first-in-class ANXA3 degrader for the treatment of triple-negative breast cancer[J].Acta Pharmaceutica Sinica B,2023,第4期
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Bo Jin1,Xuechao Pang1,Qingce Zang1,Man Ga1,Jing Xu1,Zhigang Luo1,Ruiping Zhang1,Jiangong Shi1,Jiuming He1,2,Zeper Abliz1,3,4(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;NMPA Key Laboratory for Safety Research and Evaluation of Innovative Drug;Key Laboratory of Mass Spectrometry Imaging and Metabolomics(Minzu University of China),National Ethnic Affairs Commission;Key Laboratory of Ethnomedicine of Ministry of Education,School of Pharmacy,Minzu University of China).Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets[J].Acta Pharmaceutica Sinica B,2023,第4期
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Xiaoxi Lv1,Shanshan Liu2,Chang Liu,Yunxuan Li4,Tingting Zhang4,Jie Qi5,Ke Li4,Fang Hua1,Bing Cui1,Xiaowei Zhang1,Yuxin Liu1,Jiaojiao Yu1,Jinmei Yu1,Li Li1,Xia Li5,Zhigang Yao6,Bo Huang7(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College;National Clinical Research Center for Metabolic Diseases,Key Laboratory of Diabetes Immunology,Ministry of Education,And Department of Metabolism and Endocrinology,The Second Xiangya Hospital of Central South University;Drug Clinical Trial Institution,Children’s Hospital,Capital Institute of Pediatrics;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College;Shandong University;Department of Respiratory Medicine,Beijing Friendship Hospital,Capital Medical University;Institute of Basic Medicine,Chinese Academy of Medical Sciences & Peking Union Medical College).TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2[J].Acta Pharmaceutica Sinica B,2023,第4期
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