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Qunjie Bi1,Xu Song2,Yangyang Zhao1,Xueyi Hu1,Huan Yang1,Rongrong Jin1,Yu Nie1(National Engineering Research Center for Biomaterials,College of Biomedical Engineering,Sichuan University;NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial & Institute of Regulatory Science for Medical Devices & NMPA Research Base of Regulatory Science for Medical Devices,Sichuan University).Mucus-penetrating nonviral gene vaccine processed in the epithelium for inducing advanced vaginal mucosal immune responses[J].Acta Pharmaceutica Sinica B,2023,第3期
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Zheng Zhou,Keying Li,Yongchao Chu,Chao Li,Tongyu Zhang,Peixin Liu,Tao Sun,Chen Jiang(Department of Pharmaceutics,School of Pharmacy,Fudan University,Key Laboratory of Smart Drug Delivery,Ministry of Education,State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science).ROS-removing nano-medicine for navigating inflammatory microenvironment to enhance anti-epileptic therapy[J].Acta Pharmaceutica Sinica B,2023,第3期
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Xing Duan1,Yi Zhang2,Mengran Guo2,Na Fan1,Kepan Chen1,Shugang Qin1,Wen Xiao1,Qian Zheng1,Hai Huang1,Xiawei Wei1,Yuquan Wei1,Xiangrong Song1(Department of Critical Care Medicine,Department of Clinical Pharmacy,Frontiers Science Center for Disease-related Molecular Network,State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University;West China Hospital,Sichuan University).Sodium alginate coating simultaneously increases the biosafety and immunotherapeutic activity of the cationic mRNA nanovaccine[J].Acta Pharmaceutica Sinica B,2023,第3期
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Xin Jin1,2,3,Shuai Wang1,2,Limin Zhao1,2,3,Wenjuan Huang1,2,Yinxiang Zhang1,2,Christophe Pannecouque4,Erik De Clercq4,Ge Meng1,2,Huri Piao3,Fener Chen1,2,3(Engineering Center of Catalysis and Synthesis for Chiral Molecules,Department of Chemistry,Fudan University;Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs;Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules,Ministry of Education,College of Pharmacy,Yanbian University;Rega Institute for Medical Research,KU Leuven).Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors:Boosting the safety and metabolic stability[J].Acta Pharmaceutica Sinica B,2023,第3期
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Sae-Bom Yoon1,2,Hyowon Hong1,Hee-Jong Lim1,Ji Hye Choi1,Yoon Pyo Choi3,Seong Wook Seo3,Hyuk Woo Lee3,Chong Hak Chae1,Woo-Kyu Park1,Hyun Young Kim1,Daeyoung Jeong1,Tran Quang De1,Chang-Seon Myung2,Heeyeong Cho1(Therapeutics & Biotechnology Division,Korea Research Institute of Chemical Technology;Department of Pharmacology,Chungnam National University College of Pharmacy;Future Medicine Co.Ltd.Rm616 LH-Business Growth Center).A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway[J].Acta Pharmaceutica Sinica B,2023,第3期
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Zhe Chen1,2,Chaoyang Meng1,3,Junhua Mai1,Yongbin Liu1,Hangwen Li4,Haifa Shen1,5(Department of Nanomedicine,Houston Methodist Academic Institute;Xiangya Hospital of Central South University;Department of Hepatobiliary and Pancreatic Surgery,First Affiliated Hospital,Zhejiang University School of Medicine;Stemirna Therapeutics;Immuno Q Therapeutics).An mRNA vaccine elicits STING-dependent antitumor immune responses[J].Acta Pharmaceutica Sinica B,2023,第3期
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Xueqin Huang,Bingbing Sheng,Hemi Tian,Qiuxia Chen,Yingqi Yang,Brian Bui2,Jiang Pi3,Huaihong Cai3,Shanze Chen,Jianglin Zhang,Wei Chen2,Haibo Zhou,Pinghua Sun(The Second Clinical Medical College (Shenzhen People’s Hospital),College of Pharmacy,Jinan University;Department of Physics,the University of Texas at Arlington;Department of Chemistry,Jinan University).Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy[J].Acta Pharmaceutica Sinica B,2023,第3期
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Zhuo Feng1,Yuchen Wang1,Haiheng Xu1,Yunfei Guo1,Wen Xia1,Chenxuan Zhao1,Xiaozhi Zhao2,Jinhui Wu1,3(State Key Laboratory of Pharmaceutical Biotechnology,Chemistry and Biomedicine Innovation Center,Medical School of Nanjing University;Department of Andrology,Drum Tower Hospital,Medical School of Nanjing University;Jiangsu Key Laboratory for Nano Technology,Nanjing University).Recent advances in bacterial therapeutics based on sense and response[J].Acta Pharmaceutica Sinica B,2023,第3期
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Minxuan Xu1,2,3,Jun Tan1,2,Liancai Zhu3,Chenxu Ge1,2,3,Wei Dong4,Xianling Dai1,3,Qin Kuang1,3,Shaoyu Zhong1,2,Lili Lai1,2,Chao Yi1,2,Qiang Li1,2,Deshuai Lou1,2,Linfeng Hu1,2,3,Xi Liu1,2,Gang Kuang1,2,Jing Luo1,2,Jing Feng3,Bochu Wang3(Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region,School of Biological and Chemical Engineering,Chongqing University of Education;College of Modern Health Industry,Chongqing University of Education;Key Laboratory of Biorheological Science and Technology (Chongqing University),Ministry of Education,College of Bioengineering,Chongqing University;Shandong Cancer Hospital and Institute,Shandong First Medical University & Shandong Academy of Medical Sciences).The deubiquitinating enzyme 13 retards non-alcoholic steatohepatitis via blocking inactive rhomboid protein 2-dependent pathway[J].Acta Pharmaceutica Sinica B,2023,第3期
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Xingcai Zhang1,Luo Hai2,Yibo Gao2,3,4,5,Guocan Yu6,Yingli Sun3,7,8(School of Engineering and Applied Sciences,Harvard University;Central Laboratory,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;Department of Thoracic Surgery,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;Laboratory of Translational Medicine,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology,Department of Chemistry,Tsinghua University;University of Chinese Academy of Sciences;CAS Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy of Sciences/China National Center for Bioinformation).Lipid nanomaterials-based RNA therapy and cancer treatment[J].Acta Pharmaceutica Sinica B,2023,第3期
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Tengjie Yu1,Zhihao Zhou1,Shijia Liu2,Changjian Li1,Zhi-Wei Zhang3,Yong Zhang3,Wei Jin1,Keanqi Liu1,Shuying Mao1,Lei Zhu2,Lin Xie1,Guangji Wang1,Yan Liang1(Key Lab of Drug Metabolism & Pharmacokinetics,State Key Laboratory of Natural Medicines,China Pharmaceutical University;Affliated Hospital of Nanjing University of Chinese Medicine;College of Chemical & Pharmaceutical Engineering,Hebei University of Science & Technology).The role of phosphatidylcholine 34:1 in the occurrence,development and treatment of ulcerative colitis[J].Acta Pharmaceutica Sinica B,2023,第3期
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Qian Zhou1,Meiling Le1,Yiyi Yang1,Wenjuan Wang2,Yuqi Huang1,Quan Wang1,Yijing Tian1,Meiyan Jiang1,Yong Rao2,3,Hai-Bin Luo1,2,3,Yinuo Wu1(School of Pharmaceutical Sciences,Sun Yat-sen University;Key Laboratory of Tropical Biological Resources of Ministry of Education and One Health Institute,School of Pharmaceutical Sciences,Hainan University;Song Li' Academician Workstation of Hainan University (School of Pharmaceutical Sciences)).Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia:Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis[J].Acta Pharmaceutica Sinica B,2023,第3期
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Lu Zhang1,Xiaolei Zhou2,Bowen Liu3,Xuhe Shi1,Xianmeng Li1,Feifei Xu1,Xueli Fu1,Xue Wang1,Kai Ye1,Tianzhi Jin1,Huimin Sun1,Qianqian Li1,Weiying Zhang1,Lihong Ye1(State Key Laboratory of Medicinal Chemical Biology,Tianjin Key Laboratory of Protein Sciences,Department of Biochemistry and Molecular Biology,College of Life Sciences,Nankai University;College of Food Science & Biology,Hebei University of Science and Technology;Henan Key Laboratory of Immunology and Targeted Drugs,School of Laboratory Medicine,Xinxiang Medical University).HBXIP blocks myosin-ⅡA assembly by phosphorylating and interacting with NMHC-ⅡA in breast cancer metastasis[J].Acta Pharmaceutica Sinica B,2023,第3期
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Xiaoli Wei1,Fan Yin2,3,Miaomiao Wu1,3,Qianqian Xie3,4,Xueqin Zhao3,4,Cheng Zhu1,Ruiqian Xie3,4,Chongqing Chen3,4,Menghua Liu3,4,Xueying Wang1,Ruixue Ren1,Guijie Kang3,4,Chenwen Zhu1,Jingjing Cong3,4,Hua Wang1,4,Xuefu Wang3,4(Department of Oncology,the First Affiliated Hospital of Anhui Medical University;Department of Pharmacy,Huainan First People's Hospital,the First Affiliated Hospital of Anhui University of Science and Technology;School of Pharmacy,Anhui Medical University;Inflammation and Immune Mediated Diseases Laboratory of Anhui Province,Anhui Medical University).G protein-coupled receptor 35 attenuates nonalcoholic steatohepatitis by reprogramming cholesterol homeostasis in hepatocytes[J].Acta Pharmaceutica Sinica B,2023,第3期
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Ling-Ling Wu1,2,3,Qinxin Zhao1,2,3,Qinghua Wang1,Qingyang Zhang1,Feiya Yang2,3,Bo Zheng4,Hai-Yu Hu1,Nianzeng Xing2,3,5(State Key Laboratory of Bioactive Substances and Function of Natural Medicine,Institute of Materia Medica,Peking Union Medical College and Chinese Academy of Medical Sciences;Department of Urology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;Department of Pathology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;Department of Urology,Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital,Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University).Membrane dual-targeting probes:A promising strategy for fluorescence-guided prostate cancer surgery and lymph node metastases detection[J].Acta Pharmaceutica Sinica B,2023,第3期
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Shiyang Shen,Teng Li,Jinyi Fan,Quanlin Shao,He Dong,Xiao Xu,Ran Mo(State Key Laboratory of Natural Medicines,Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases,Center of Advanced Pharmaceuticals and Biomaterials,School of Life Science and Technology,China Pharmaceutical University).Lipid-polymer hybrid nanoparticle with cell-distinct drug release for treatment of stemness-derived resistant tumor[J].Acta Pharmaceutica Sinica B,2023,第3期
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Senlin Li1,2,Siyu Chen3,Zhihui Dong1,Xingdong Song2,Xiuling Li1,Ziqi Huang2,Huiru Li2,Linzhuo Huang1,Ganyuan Zhuang1,Ran Lan2,Mingyan Guo4,Wende Li3,Phei Er Saw1,Lei Zhang2(Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Guangdong-Hong Kong Joint Laboratory for RNA Medicine,Sun Yat-sen Memorial Hospital,Sun Yat-sen University;Department of Hepatobiliary Surgery,Sun Yat-sen Memorial Hospital,Sun Yat-sen University;Guangdong Laboratory Animals Monitoring Institute,Guangdong Key Laboratory of Laboratory Animals;Department of Anesthesiology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University).Concurrent silencing of TBCE and drug delivery to overcome platinum-based resistance in liver cancer[J].Acta Pharmaceutica Sinica B,2023,第3期
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Keliang Chen1,Tao Wang2,Yong Li1,Jun Wu1,Cheng-Xiao Zhao1,Sheng Liu1,Fengrun Sun2,Yehong Fang2,Jiahuan Hu1,Jinping Hu1,Chong-Jing Zhang1,Haibo Yu1,Chao Ma2,Shi-Shan Yu1(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Institute of Basic Medical Sciences,Neuroscience Center,Chinese Academy of Medical Sciences,Department of Human Anatomy,Histology and Embryology,School of Basic Medicine,Peking Union Medical College).Rhodojaponin Ⅵ indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain[J].Acta Pharmaceutica Sinica B,2023,第3期
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Yanfang Yang1,Ke Feng2,Liying Yuan1,Yuxin Liu1,Mengying Zhang3,Kaimin Guo3,Zequn Yin4,Wenjia Wang3,Shuiping Zhou5,6,He Sun3,5,6,Kaijing Yan3,5,6,Xijun Yan5,6,Xuerui Wang4,Yajun Duan4,7,Yunhui Hu3,Jihong Han1,4(College of Life Sciences,State Key Laboratory of Medicinal Chemical Biology,Key Laboratory of Bioactive Materials of Ministry of Education,Nankai University;Department of Physiology,Binzhou Medical University;Cloudphar Pharmaceuticals Co.Ltd.;Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes,Hefei University of Technology;The State Key Laboratory of Core Technology in Innovative Chinese Medicine,Tasly Academy,Tasly Holding Group Co.Ltd.;Tasly Pharmaceutical Group Co.Ltd.;Department of Cardiology,the First Affiliated Hospital of USTC,Division of Life Science and Medicine,University of Science and Technology of China).Compound Danshen Dripping Pill inhibits hypercholesterolemia/atherosclerosis-induced heart failure in ApoE and LDLR dual deficient mice via multiple mechanisms[J].Acta Pharmaceutica Sinica B,2023,第3期
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Zhihui Dong1,2,Zhuoshan Huang1,2,Senlin Li1,2,Ying Wang1,2,Yandan Yao1,2,Xianzhu Yang3,Xiaoding Xu1,2(Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Medical Research Center,Sun Yat-sen Memorial Hospital,Sun Yat-sen University;RNA Biomedical Institute,Sun Yat-sen Memorial Hospital,Sun Yat-sen University;School of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou International Campus).Nanoparticles(NPs)-mediated systemic mRNA delivery to reverse trastuzumab resistance for effective breast cancer therapy[J].Acta Pharmaceutica Sinica B,2023,第3期
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Jiang Wu1,Wenfeng Gou2,Zhiyun Wang3,Huajie Chang3,Deguan Li2,Wenbin Hou2,Changxiao Liu4(Department of Pharmaceutical Engineering,School of Chemical Engineering and Technology,Tianjin University;Institute of Radiation Medicine,Chinese Academy of Medical Sciences;School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine;Research Center for New Drug Evaluation,the State Laboratory of Drug Delivery Technology and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research).Discovery of the radio-protecting effect of Ecliptae Herba,its constituents and targeting p53-mediated apoptosis in vitro and in vivo[J].Acta Pharmaceutica Sinica B,2023,第3期
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Ning Shao1,Xueyang Ma2,Ying-Ying Zhang1,Donghui Yang2,Ming Ma2,Gong-Li Tang1,3(State Key Laboratory of Bioorganic and Natural Products Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences;State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University;School of Chemistry and Materials Science Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences).Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis[J].Acta Pharmaceutica Sinica B,2023,第3期
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Juanjuan Feng1,2,Zhengke Lian1,Xinting Xia1,Yue Lu1,Kewen Hu3,Yunpeng Zhang1,Yanan Liu1,Longmiao Hu1,Kun Yuan1,Zhenliang Sun2,Xiufeng Pang1(Shanghai Key Laboratory of Regulatory Biology,School of Life Sciences,East China Normal University;Joint Center for Translational Medicine,Southern Medical University Affiliated Fengxian Hospital;Cancer Institute,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University).Targeting metabolic vulnerability in mitochondria conquers MEK inhibitor resistance in KRAS-mutant lung cancer[J].Acta Pharmaceutica Sinica B,2023,第3期
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(Editoral Office of Acta Pharmaceutica Sinica).Information for Authors[J].Acta Pharmaceutica Sinica B,2023,第3期
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Haowen Xu1,2,Jiahao Chen1,Pan Chen1,Weifeng Li1,Jingjing Shao1,2,Shanshan Hong1,Yi Wang1,Lingfeng Chen2,Wu Luo1,3,Guang Liang1,2(Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University;School of Pharmaceutical Sciences,Hangzhou Medical College;Medical Research Center,the First Affiliated Hospital of Wenzhou Medical University).Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases[J].Acta Pharmaceutica Sinica B,2023,第2期
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Chen Fu1,2,Lifeng Yu1,Yuxi Miao1,2,3,Xinli Liu4,Zhaojin Yu1,2,Minjie Wei1,2,3(Department of Pharmacology,School of Pharmacy,China Medical University;Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation,China Medical University;Liaoning Medical Diagnosis and Treatment Center;Department of Digestive Oncology,Cancer Hospital of China Medical University,Liaoning Cancer Hospital&Institute).Peptide-drug conjugates(PDCs):a novel trend of research and development on targeted therapy, hype or hope?[J].Acta Pharmaceutica Sinica B,2023,第2期
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Lujing Geng1,Tong Lu2,Huaqing Jing1,Yue Zhou1,Xiaoyang Liang1,Jiao Li2,Nan Li1(Tianjin Key Laboratory of Drug Delivery&High-Efficiency,School of Pharmaceutical Science and Technology,Tianjin University;School of Precision Instruments and Optoelectronics Engineering,Tianjin University).Iron-based and BRD4-downregulated strategy for amplified ferroptosis based on pH-sensitive/NIR-Ⅱ-boosted nano-matchbox[J].Acta Pharmaceutica Sinica B,2023,第2期
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Tao He,Mingxing Hu,Shunyao Zhu,Meiling Shen,Xiaorong Kou,Xiuqi Liang,Lu Li,Xinchao Li,Miaomiao Zhang,Qinjie Wu,Changyang Gong(State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University).A tactical nanomissile mobilizing antitumor immunity enables neoadjuvant chemo-immunotherapy to minimize postsurgical tumor metastasis and recurrence[J].Acta Pharmaceutica Sinica B,2023,第2期
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Meng Chen1,2,Zhengyan Guo1,3,Jinyuan Sun1,2,Wei Tang1,2,Min Wang1,4,Yue Tang1,Pengwei Li1,Bian Wu1,2,Yihua Chen1,2(State Key Laboratory of Microbial Resources&CAS Key Laboratory of Microbial Physiological and Metabolic Engineering,Institute of Microbiology,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Laboratory of Microbial Metabolic Engineering,Institute of Medicinal Biotechnology,Chinese Academy of Medical Science&Peking Union Medical College;School of Biotechnology and Health Sciences,Wuyi University).Insights into the biosynthesis of septacidin L-heptosamine moiety unveils a VOC family sugar epimerase[J].Acta Pharmaceutica Sinica B,2023,第2期
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