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Yubo Wang1,Jian Min2,Xiangping Deng1,Tian Feng1,Hebing Hu2,Xinyi Guo1,Yan Cheng1,Baohua Xie1,Yu Yang2,Chun-Chi Chen2,Rey-Ting Guo2,Chune Dong1,3,Hai-Bing Zhou1,3,4(Department of Gynecological Oncology,Zhongnan Hospital of Wuhan University,School of Pharmaceutical Sciences,Wuhan University;State Key Laboratory of Biocatalysis and Enzyme Engineering,National&Local Joint Engineering Research Center of High-throughput Drug Screening Technology,Hubei Key Laboratory of Industrial Biotechnology,School of Life Sciences,Hubei University;Frontier Science Center for Immunology and Metabolism,State Key Laboratory of Virology,Provincial Key Laboratory of Developmentally Originated Disease,Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE)and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals,Wuhan University;Wuhan Research Center for Infectious Diseases and Cancer,Chinese Academy of Medical Sciences,Zhongnan Hospital of Wuhan University).Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer[J].Acta Pharmaceutica Sinica B,2023,第12期
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Kaikai Zhang1,Lijian Chen1,Jianzheng Yang1,Jiali Liu1,Jiahao Li1,Yi Liu1,Xiuwen Li1,Long Chen1,Clare Hsu1,Jiahao Zeng1,Xiaoli Xie2,Qi Wang1(Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification,School of Forensic Medicine,Southern Medical University;Department of Toxicology,School of Public Health,Southern Medical University(Guangdong Provincial Key Laboratory of Tropical Disease Research)).Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner[J].Acta Pharmaceutica Sinica B,2023,第12期
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Xintong Zhao,Jing Feng,Jie Zhang,Zunsheng Han,Yuhua Hu,Hui-Hui Shao,Tianlei Li,Jie Xia,Kangfan Lei,Weiping Wang,Fangfang Lai,Yuan Lin,Bo Liu,Kun Zhang,Chi Zhang,Qingyun Yang,Xinyu Luo,Hanyilan Zhang,Chuang Li,Wenxuan Zhang,Song Wu(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College).Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection[J].Acta Pharmaceutica Sinica B,2023,第12期
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Youchao Deng1,Xiaosheng Song2,Iredia D.Iyamu1,Aiping Dong2,Jinrong Min2,3,Rong Huang1(Department of Medicinal Chemistry and Molecular Pharmacology,Center for Cancer Research,Institute for Drug Discovery,Purdue University;Structural Genomics Consortium and Department of Physiology,University of Toronto;Hubei Key Laboratory of Genetic Regulation and Integrative Biology,School of Life Sciences,Central China Normal University).A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors[J].Acta Pharmaceutica Sinica B,2023,第12期
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Peng Hua1,Ruifeng Liang1,Yanbei Tu1,Yuying Yin1,Man-Kay Law2,Meiwan Chen1(State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau;State Key Laboratory of Analog and Mixed-Signal VLSI,IME and FST-ECE,University of Macau).Reactive oxygen species and nitric oxide scavenging nanoparticles alleviating rheumatoid arthritis through adjusting the seeds and growing soils[J].Acta Pharmaceutica Sinica B,2023,第12期
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Shixin Duan,Xinyi Lou,Shiyi Chen,Hongchao Jiang,Dongxin Chen,Rui Yin,Mengkai Li,Yuseng Gou,Wenjuan Zhao,Lei Sun,Feng Qian(Shanghai Frontiers Science Center of Drug Target Identification and Delivery,National Key Laboratory of Innovative Immunotherapy,Engineering Research Center of Cell&Therapeutic Antibody,Ministry of Education,School of Pharmacy,Shanghai Jiao Tong University).Macrophage LMO7 deficiency facilitates inflammatory injury via metabolic-epigenetic reprogramming[J].Acta Pharmaceutica Sinica B,2023,第12期
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Feng Long1,Yao Pan1,Jinheng Li1,Suinan Sha1,Xiubo Shi1,Haoyan Guo1,Chuanqing Huang1,Qian Xiao1,Chao Fan1,Xingmei Zhang2,Jun-Bing Fan1,Ying Wang1(Cancer Research Institute,Experimental Education/Administration Center,Key Laboratory of Functional Proteomics of Guangdong Province,School of Basic Medical Sciences,Southern Medical University;Department of Neurobiology,School of Basic Medical Sciences,Southern Medical University).Orange-derived extracellular vesicles nanodrugs for efficient treatment of ovarian cancer assisted by transcytosis effect[J].Acta Pharmaceutica Sinica B,2023,第12期
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Yan Zhang1,Haiyun Zhang2,Faquan Zhao2,Zhengping Jiang1,Yuanlu Cui2,Meitong Ou1,Lin Mei1,Qiangsong Wang1(Tianjin Key Laboratory of Biomedical Materials,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College;State Key Laboratory of Component-based Chinese Medicine,Research Center of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine).Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment[J].Acta Pharmaceutica Sinica B,2023,第12期
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Xiaodi Liu1,2,Qi Zhang2,3,Yixia Liang3,Shiyu Xiong2,Yan Cai,Jincheng Cao2,Yanni Xu2,Xiaolin Xu2,Ye Wu2,Qiang Lu1,Xiaoding Xu2,3,Baoming Luo2(Department of Ultrasound,Laboratory of Ultrasound Imaging and Drug,West China Hospital,Sichuan University;Department of Ultrasound,Sun Yat-sen Memorial Hospital,Sun Yat-sen University;Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Sun Yat-sen Memorial Hospital,Sun Yat-sen University;Department of Ultrasound,Central People’s Hospital of Zhanjiang).Nanoparticles(NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy[J].Acta Pharmaceutica Sinica B,2023,第12期
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Jing Ye1,Jin Zhang1,Yanghui Zhu1,Lian Wang1,2,Xian Jiang1,Bo Liu1,Gu He1,2(Department of Dermatology,State Key Laboratory of Biotherapy,West China Hospital,Sichuan University;Laboratory of Dermatology,Clinical Institute of Inflammation and Immunology(CIII),Frontiers Science Center for Disease Related Molecular Network).Targeting autophagy and beyond:Deconvoluting the complexity of Beclin-1 from biological function to cancer therapy[J].Acta Pharmaceutica Sinica B,2023,第12期
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Yingqiang Liu1,Zhengsheng Zhan2,Zhuang Kang3,Mengyuan Li1,Yongcong Lv2,Shenglan Li3,Linjiang Tong1,Fang Feng1,Yan Li1,Mengge Zhang1,4,Yaping Xue1,4,5,Yi Chen1,4,Tao Zhang1,Peiran Song1,6,Yi Su1,Yanyan Shen1,Yiming Sun1,Xinying Yang1,Yi Chen1,Shanyan Yao2,Hanyu Yang7,Caixia Wang7,Meiyu Geng1,4,Wenbin Li3,Wenhu Duan2,Hua Xie1,6,4,5,Jian Ding1,4,5(Division of Antitumor Pharmacology,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;Department of Medicinal Chemistry,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;Department of Neuro-oncology,Cancer Center,Beijing Tiantan Hospital,Capital Medical University;University of Chinese Academy of Sciences;Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences;Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;Shanghai Runshi Pharmaceutical Technology Co.Ltd.).Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma[J].Acta Pharmaceutica Sinica B,2023,第12期
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Xuesong Li1,Xiang Chen1,Longbin Zheng1,2,Minghong Chen1,Yunjia Zhang1,Ruigong Zhu1,Jiajing Chen3,Jiaming Gu1,Quanwen Yin1,Hong Jiang1,Xuan Wu1,Xian Ji1,Xin Tang1,Mengdie Dong1,Qingguo Li4,Yuanqing Gao1,Hongshan Chen1,4,5,6(Key Laboratory of Cardiovascular and Cerebrovascular Medicine,School of Pharmacy,Nanjing Medical University;Department of Anesthesiology,Sir Run Run Hospital,Nanjing Medical University;Department of Pharmacy,Huashan Hospital,Fudan University;Department of Cardiothoracic Surgery,the Second Affiliated Hospital of Nanjing Medical University;Key Laboratory of Targeted Intervention of Cardiovascular Disease,Collaborative Innovation Center for Cardiovascular Disease Translational Medicine,Nanjing Medical University;Department of Cardiology,Huai'an First People's Hospital Affiliated with Nanjing Medical University).Non-canonical STING-PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response[J].Acta Pharmaceutica Sinica B,2023,第12期
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Lina Guo1,Jinsong Ding1,Wenhu Zhou1,2(Xiangya School of Pharmaceutical Sciences,Central South University;Key Laboratory of Biological Nanotechnology of National Health Commission,Xiangya Hospital).Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy[J].Acta Pharmaceutica Sinica B,2023,第12期
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Qiaozi Wang1,2,Yanan Song1,2,Jinfeng Gao1,2,Qiyu Li1,2,Jing Chen1,2,Yifang Xie3,Zhengmin Wang1,2,Haipeng Tan1,2,Hongbo Yang1,2,Ning Zhang1,2,Juying Qian1,2,Zhiqing Pang4,Zheyong Huang1,2,Junbo Ge1,3,2(Department of Cardiology,Zhongshan Hospital,Fudan University,Shanghai Institute of Cardiovascular Diseases;National Clinical Research Center for Interventional Medicine;Institute of Biomedical Sciences,Fudan University;School of Pharmacy,Fudan University,Key Laboratory of Smart Drug Delivery,Ministry of Education).Hippo pathway-manipulating neutrophil-mimic hybrid nanoparticles for cardiac ischemic injury via modulation of local immunity and cardiac regeneration[J].Acta Pharmaceutica Sinica B,2023,第12期
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Jia-Luo Huang1,Xue-Long Yan1,2,Dong Huang1,Lu Gan1,Huahua Gao1,Run-Zhu Fan1,Shen Li1,Fang-Yu Yuan1,Xinying Zhu1,Gui-Hua Tang1,Hong-Wu Chen3,Junjian Wang1,Sheng Yin1(School of Pharmaceutical Sciences,Sun Yat-sen University;School of Pharmacy,Guizhou Medical University;School of Medicine,University of California Davis).Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer[J].Acta Pharmaceutica Sinica B,2023,第12期
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Wenjing Yu1,2,Yuehuai Hu1,2,Zhiping Liu3,Kaiteng Guo1,Dinghu Ma1,Mingxia Peng1,Yuemei Wang1,Jing Zhang1,Xiaolei Zhang1,Panxia Wang1,Jiguo Zhang4,Peiqing Liu1,2,4,Jing Lu1,2(National and Local United Engineering Lab of Druggability and New Drugs Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University;Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University;School of Pharmacy,Jinan University;School of Pharmaceutical Sciences,Shandong First Medical University&Shangdong Academy of Medical Sciences).Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis[J].Acta Pharmaceutica Sinica B,2023,第12期
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Chuanfeng Liu1,Lide Hu1,Guanyu Dong1,Ying Zhang1,Edeildo Ferreira da Silva-Júnior2,Xinyong Liu1,Luis Menéndez-Arias3,Peng Zhan1(Department of Medicinal Chemistry,Key Laboratory of Chemical Biology(Ministry of Education),School of Pharmaceutical Sciences,Shandong University;Laboratory of Medicinal Chemistry,Institute of Pharmaceutical Sciences,Federal University of Alagoas;Centro de Biología Molecular“Severo Ochoa”(Consejo Superior de Investigaciones Científicas&Universidad Autónoma de Madrid)).Emerging drug design strategies in anti-influenza drug discovery[J].Acta Pharmaceutica Sinica B,2023,第12期
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Li-Min Zhao1,2,3,Christophe Pannecouque4,Erik De Clercq4,Shuai Wang2,3,Fen-Er Chen1,2,3(Key Laboratory of Natural Resources of Changbai Mountain&Functional Molecules,Ministry of Education,Yanbian University College of Pharmacy,Yanbian University;Engineering Center of Catalysis and Synthesis for Chiral Molecules,Department of Chemistry,Fudan University;Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs;Rega Institute for Medical Research).Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility[J].Acta Pharmaceutica Sinica B,2023,第12期
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Huaqing Jing1,Yingzi Ren1,Yue Zhou1,Min Xu1,Sona Krizkova2,Zbynek Heger2,Qiang Lu1,Siyu Wang1,Xiaoyang Liang1,Vojtech Adam2,Nan Li1(Tianjin Key Laboratory of Drug Delivery&High-Efficiency,School of Pharmaceutical Science and Technology,Tianjin University;Department of Chemistry and Biochemistry,Mendel University in Brno).Remodeling of the liver fibrosis microenvironment based on nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic activity[J].Acta Pharmaceutica Sinica B,2023,第12期
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Qiujun Qiu1,Sunhui Chen2,Huining He3,Jixiang Chen1,Xinyi Ding1,Dongdong Wang1,Jiangang Yang1,Pengcheng Guo1,Yang Li1,Jisu Kim1,Jianyong Sheng1,Chao Gao1,4,Bo Yin5,Shihao Zheng6,Jianxin Wang1,7(Department of Pharmaceutics,School of Pharmacy,Fudan University&Key Laboratory of Smart Drug Delivery,Ministry of Education;Department of Pharmacy,Fujian Provincial Hospital&Provincial Clinical Medical College of Fujian Medical University;Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics,School of Pharmacy,Tianjin Medical University;Institute of Tropical Medicine,Guangzhou University of Chinese Medicine;Department of Radiology,Huashan Hospital,Fudan University;Department of Neurosurgery,Fujian Provincial Hospital&Provincial Clinical Medical College of Fujian Medical University;Institute of Materia Medica,Academy of Chinese and Western Integrative Medicine,Fudan University).An injectable signal-amplifying device elicits a specific immune response against malignant glioblastoma[J].Acta Pharmaceutica Sinica B,2023,第12期
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Junting Zhang1,3,Yiying Li1,3,Jianchao Zhang1,3,Lu Liu4,Yuan Chen5,Xusheng Yang5,Xueyi Liao1,3,Muhua He4,Zihui Jia5,Jun Fan6,Jin-Song Bian4,Xiaowei Nie1,3(Shenzhen Institute of Respiratory Disease,Shenzhen Key Laboratory of Respiratory Disease,Shenzhen People’s Hospital(the Second Clinical Medical College,Jinan University;the First Affiliated Hospital,Southern University of Science and Technology);Post-Doctoral Scientific Research Station of Basic Medicine,Jinan University;Department of Pharmacology,School of Medicine,Southern University of Science and Technology;Lung Transplant Group,Wuxi People’s Hospital Affiliated to Nanjing Medical University;Department of Medical Biochemistry and Molecular Biology,School of Medicine,Jinan University).ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17[J].Acta Pharmaceutica Sinica B,2023,第12期
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Wenjun Yu1,2,3,4,Haixia Xu1,2,5,Zhe Sun1,2,Yuxin Du1,2,Shiqun Sun1,2,Miyesaier Abudureyimu2,6,Mengjiao Zhang1,2,Jun Tao7,Junbo Ge1,2,Jun Ren1,2,Yingmei Zhang1,2(Department of Cardiology and Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital,Fudan University;National Clinical Research Center for Interventional Medicine;Department of Cardiovascular Surgery,Zhongnan Hospital of Wuhan University;Hubei Provincial Engineering Research Center of Minimally Invasive Cardiovascular Surgery;Department of Cardiology,Affiliated Hospital of Nantong University;Cardiovascular Department,Shanghai Xuhui Central Hospital,Zhongshan-Xuhui Hospital,Fudan University;Department of Cardiovascular Surgery,Sun Yat-sen Memorial Hospital,Sun Yat-sen University).TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNA-PKcs cytosolic retention and DNA damage[J].Acta Pharmaceutica Sinica B,2023,第12期
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Mingjin Wang,Weida Wang,Shen You,Zhenyan Hou,Ming Ji,Nina Xue,Tingting Du,Xiaoguang Chen,Jing Jin(Department of Pharmacology,State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College).ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells[J].Acta Pharmaceutica Sinica B,2023,第12期
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Yanping Wang1,Weihong Du2,Xiaoyan Hu2,Xin Yu3,Chun Guo4,Xinchun Jin2,Wei Wang5(Department of Neurology,the Second Affiliated Hospital of Jiaxing City;Beijing Key Laboratory of Cancer Invasion and Metastasis Research,Department of Histology and Embryology,School of Basic Medical Sciences,Advanced Innovation Center for Human Brain Protection,Capital Medical University;Bengbu Medical College(Department of Neurology,the Second Hospital of Jiaxing City);School of Biosciences,University of Sheffield;Department of Physiology and Pathophysiology,Capital Medical University).Targeting the blood-brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms,and their interplays[J].Acta Pharmaceutica Sinica B,2023,第12期
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Yongho Jang1,Jeehun Park2,Pilsu Kim3,Eun-Joo Park4,Hyungjin Sun5,Yujin Baek6,Jaehun Jung1,Tai-kyong Song3,Junsang Doh2,6,7,Hyuncheol Kim1,8(Department of Chemical and Biomolecular Engineering,Sogang University;Research Institute of Advanced Materials(RIAM),Institute of Engineering Research,Seoul National University;Department of Electronic Engineering,Sogang University;Biomedical Research Institute&Department of Radiology,Seoul National University Hospital;Interdisciplinary Program in Bioengineering,Seoul National University;Department of Materials Science and Engineering,Seoul National University;Institute of Engineering Research,Bio-MAX Institute,Seoul National University;Department of Biomedical Engineering,Sogang University).Development of exosome membrane materials-fused microbubbles for enhanced stability and efficient drug delivery of ultrasound contrast agent[J].Acta Pharmaceutica Sinica B,2023,第12期
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Yong Ke1,En Zhang2,3,Jianming Guo2,3,Xiaoxiao Zhang2,3,Lei Wang1,Duo Chen2,3,Xinkui Fang2,Jianwei Zhu1,Feng Li4,Tao Sun2,3,Baohong Zhang1(Engineering Research Center of Cell&Therapeutic Antibody,Ministry of Education,School of Pharmacy,Shanghai Jiao Tong University;School of Agriculture and Biology,Shanghai Jiao Tong University;Shanghai Municipal Veterinary Key Laboratory;Shanghai Public Health Clinical Center,Fudan Univeristy).Immunogenicity of mucosal COVID-19 vaccine candidates based on the highly attenuated vesicular stomatitis virus vector(VSVMT) in golden syrian hamster[J].Acta Pharmaceutica Sinica B,2023,第12期
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Feifei Fang1,Yang Dai2,Hao Wang3,4,Yinchun Ji2,Xuewu Liang2,4,Xia Peng2,Jiyuan Li2,Yangrong Zhao2,Chunpu Li2,4,Danyi Wang2,4,Yazhou Li2,Dong Zhang2,Dan Zhang2,Meiyu Geng2,4,5,6,Hong Liu2,4,6,Jing Ai2,4,6,Yu Zhou3,4,6(Lingang Laboratory;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;Drug Discovery&Development Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Shandong Laboratory of Yantai Drug Discovery,Bohai Rim Advanced Research Institute for Drug Discovery;School of Pharmaceutical Science and Technology,Hangzhou Institute for Advanced Study,UCAS).Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors[J].Acta Pharmaceutica Sinica B,2023,第12期
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Yitong Liu1,2,Guiyang Xia3,Yingyi Chen1,2,Huan Xia3,Junji Xu1,2,Lijia Guo4,Sheng Lin3,Yi Liu1,2(Laboratory of Tissue Regeneration and Immunology and Department of Periodontics,Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction,School of Stomatology,Capital Medical University;Immunology Research Center for Oral and Systemic Health,Beijing Friendship Hospital,Capital Medical University;Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine;Department of Orthodontics,School of Stomatology,Capital Medical University).Purpurolide C-based microneedle promotes macrophage-mediated diabetic wound healing via inhibiting TLR4-MD2 dimerization and MYD88 phosphorylation[J].Acta Pharmaceutica Sinica B,2023,第12期
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